Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Giuseppina Morini"'
Publikováno v:
Tissue and Cell. 47:147-151
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the N/OFQ peptide (NOP) receptor, is a neuropeptide regulating gastrointestinal functions. The present study investigated the influence of acute cold-restraint stress and of short- and long-las
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf61040cb42b1c47dfb82d76584c339
https://doi.org/10.1016/j.tice.2015.01.006
https://doi.org/10.1016/j.tice.2015.01.006
Autor:
Monica Donnola, Sony Joseph, Cristina Pozzoli, Alberto Gasco, Barbara Rolando, Elisabetta Marini, Loretta Lazzarato, Roberta Fruttero, Giuseppina Morini
Publikováno v:
ChemMedChem. 8:1199-1209
A series of water-soluble (benzoyloxy)methyl esters of acetylsalicylic acid (ASA), commonly known as aspirin, are described. The new derivatives each have alkyl chains containing a nitric oxide (NO)-releasing nitrooxy group and a solubilizing moiety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfa191354b91c37a145cf0247043a5d
https://doi.org/10.1002/cmdc.201300105
https://doi.org/10.1002/cmdc.201300105
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 46(Suppl 1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6f6b77c1dd0382076e2ebe439ed56b
https://pubmed.ncbi.nlm.nih.gov/27518024
https://pubmed.ncbi.nlm.nih.gov/27518024
Autor:
Carlo Cifani, Giuseppina Morini, Carlo Polidori, Daniela Grandi, Ingrid Klöting, Maurizio Massi
Publikováno v:
Peptides. 30:727-734
In previous work, we observed that N/OFQ-induced hyperphagia is greater in DA rats, animals resistant to metabolic syndrome, than in WOKW animals, which are prone to this disease. We attributed this difference to the fact that these two strains have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd64c58b71b16f29e18df22440813fd5
https://doi.org/10.1016/j.peptides.2008.11.012
https://doi.org/10.1016/j.peptides.2008.11.012
Autor:
Giuseppina Morini, Ennio Ongini, Roberta Fruttero, Loretta Lazzarato, Gabriella Coruzzi, Elena Guaita, Monica Donnola, Stefano Biondi, Alberto Gasco, Barbara Rolando, Elisabetta Marini, Clara Cena
Publikováno v:
Journal of Medicinal Chemistry. 51:1894-1903
A new class of products in which the phenol group of salicylic acid is linked to alkanoyl moieties bearing nitrooxy functions has been synthesized and studied for their polyvalent actions. The products were stable in acid and neutral media, while the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092d64c5edf26535b786ca1574c4ea03
https://doi.org/10.1021/jm701104f
https://doi.org/10.1021/jm701104f
Autor:
Carla Petrella, Giovanna Improta, Simona Agostini, Carlo Polidori, Maria Broccardo, Giuseppina Morini, Remo Guerrini
Publikováno v:
Peptides. 28:1974-1981
Nociceptin/orphanin FQ (N/OFQ), the endogenous NOP receptor ligand, centrally modulates gastric motor and secretory functions and prevents ethanol-induced gastric lesions in rats. A recently synthesized N/OFQ analog, [(pF)Phe(4)Aib(7)Arg(14)Lys(15)]N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a436f4fae914cd8c58f78a8a43fd15e5
https://doi.org/10.1016/j.peptides.2007.07.021
https://doi.org/10.1016/j.peptides.2007.07.021
Autor:
Daniela Grandi, Maurizio Massi, Carlo Polidori, Elvira Solenghi, Giuseppina Morini, Remo Guerrini
Publikováno v:
Peptides. 28:1572-1579
The influence of peripheral nociceptin/orphanin FQ (N/OFQ) on cold restraint-induced gastric mucosal damage in the rat was investigated. Exposure to cold-restraint for 3 and 4h caused the formation of hemorrhagic lesions in the glandular portion of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a1d0a821dfa0a2390de878e6291a12
https://doi.org/10.1016/j.peptides.2007.06.019
https://doi.org/10.1016/j.peptides.2007.06.019
Publikováno v:
Alimentary Pharmacology & Therapeutics. 9:615-623
SUMMARY Background: The mechanisms responsible for the gastric ulcerogenic effect of indomethacin are unclear. The importance of basal acid secretion on morphological changes by indomethacin was investigated. Methods: Gastric lesions were macroscopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37573bfbf5b98a3209efc4750bb1349d
https://doi.org/10.1111/j.1365-2036.1995.tb00430.x
https://doi.org/10.1111/j.1365-2036.1995.tb00430.x
Publikováno v:
British Journal of Pharmacology. 137:237-244
(R)-α-methylhistamine, a selective agonist of histamine H3 receptors, promotes mucus secretion and increases the number and volume of mucus-secreting cells. The hypothesis that the increased number of mucous cells could reside in an alteration of ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09e8850682ec759725b30a9039f7b883
https://doi.org/10.1038/sj.bjp.0704853
https://doi.org/10.1038/sj.bjp.0704853
Autor:
Roberta Fruttero, Giuseppina Morini, Gabriella Coruzzi, Alberto Gasco, Marco Lucio Lolli, Claudio Medana, Loretta Lazzarato, Clara Cena, Stefano Manarini
Publikováno v:
Journal of Medicinal Chemistry. 44:3463-3468
A new series of nonsteroidal antiinflammatory drugs (NSAIDs) obtained by linking ibuprofen to selected furoxan moieties and to related furazans were synthesized and tested for their antiinflammatory, antiaggregatory, and ulcerogenic properties. All t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd58936bcdfc29671ac55c80de173143
https://doi.org/10.1021/jm0108799
https://doi.org/10.1021/jm0108799