Výsledky vyhledávání - "Giuseppina I. Truglio"

Akademický článek

A gram-scale synthesis of a macrocyclic amidinourea with strong antifungal activity through a Fukuyama tri-protected polyamine intermediate

Autor: Matteo Borgini, Francesco Orofino, Giuseppina I. Truglio, Lorenzo Balestri, Maurizio Botta

Publikováno v: ARKIVOC, Vol 2019, Iss 4, Pp 168-177 (2019)

Externí odkaz: https://doaj.org/article/7bb76cfe019d44b6a02a4c94f8917678

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Focused library of phenyl-fused macrocyclic amidinoureas as antifungal agents

Autor: Lorenzo J. I. Balestri, Ilaria D’Agostino, Enrico Rango, Chiara Vagaggini, Rosalba Marchitiello, Melinda Mariotti, Alexandru Casian, Davide Deodato, Giuseppina I. Truglio, Francesco Orofino, Maurizio Sanguinetti, Francesca Bugli, Lorenzo Botta, Elena Dreassi

Publikováno v: Molecular Diversity. 26:3399-3409

The rise of antimicrobial-resistant phenotypes and the spread of the global pandemic of COVID-19 are worsening the outcomes of hospitalized patients for invasive fungal infections. Among them, candidiases are seriously worrying, especially since the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bb419a105a8f4d774cb04b5fe01a13
https://doi.org/10.1007/s11030-022-10388-7

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A gram-scale synthesis of a macrocyclic amidinourea with strong antifungal activity through a Fukuyama tri-protected polyamine intermediate

Autor: Maurizio Botta, Francesco Orofino, Matteo Borgini, Lorenzo Balestri, Giuseppina I. Truglio

Publikováno v: ARKIVOC, Vol 2019, Iss 4, Pp 168-177 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab3c081ab632ff62748e0bcd350b0c1
https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.p010.895

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In vitro characterization, ADME analysis, and histological and toxicological evaluation of BM1, a macrocyclic amidinourea active against azole-resistant Candida strains

Autor: Federica Poggialini, Matteo Borgini, Elena Dreassi, Maurizio Botta, Rajendra Prasad, Ilaria D'Agostino, Giuseppina I. Truglio, Cecilia Martini, Nitesh Kumar Khandelwal, Diego Fiorucci, Laura Maccari, Claudio Zamperini, Francesca Bugli, Jacques F. Meis, Riccardo Torelli, Francesco Orofino, Micaela Bernabei, Maurizio Sanguinetti

Publikováno v: International Journal of Antimicrobial Agents, 55, 3
International Journal of Antimicrobial Agents, 55

Background : Among the opportunistic fungi, Candida species represent one of the most common causes of nosocomial bloodstream infections. The large use of antifungal agents, most of them launched on the market more than twenty years ago, led to the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2533cfa09c23977eae5bbd54cc308
https://doi.org/10.1016/j.ijantimicag.2019.105865

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Alkyl-guanidine Compounds as Potent Broad-Spectrum Antibacterial Agents: Chemical Library Extension and Biological Characterization

Autor: Carolina Pasero, Arianna Mancini, Mario B. Guglielmi, Giuseppina I. Truglio, Davide Deodato, Daniela Visaggio, Maurizio Botta, Teresa Ferraro, Filomena Sannio, Filomena De Luca, Ilaria D'Agostino, Rosita Del Prete, Claudio Zamperini, Jean Denis Docquier, Paolo Visca

Publikováno v: Journal of medicinal chemistry. 61(20)

Nowadays, the increasing of multidrug-resistant pathogenic bacteria represents a serious threat to public health, and the lack of new antibiotics is becoming a global emergency. Therefore, research in antibacterial fields is urgently needed to expand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f1e521ad51a7211904249370e745cc
https://pubmed.ncbi.nlm.nih.gov/30265809

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Design and synthesis of a novel inhibitor of T. Viride chitinase through an in silico target fishing protocol

Autor: Diego Fiorucci, Carolina Pasero, Giorgio Maccari, Filomena De Luca, Maurizio Botta, Davide Deodato, Jean Denis Docquier, Giuseppina I. Truglio, Francesco Orofino, Riccardo Martini

In the last ten years, we identified and developed a new therapeutic class of antifungal agents, the macrocyclic amidinoureas. These compounds are active against several Candida species, including clinical isolates resistant to currently available an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e0a12b7130d878593f020a30109ded
http://hdl.handle.net/11365/1070888

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ChemInform Abstract: Ruthenium-Catalyzed C-Alkylation of 1,3-Dicarbonyl Compounds with Primary Alcohols and Synthesis of 3-Keto-quinolines

Autor: Elena Petricci, Maurizio Taddei, Giuseppina I. Truglio, Marialaura Vecchio, Elena Cini

Publikováno v: ChemInform. 47

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66d1adf9f00bc5b7ab4f3d7c0d009af5
https://doi.org/10.1002/chin.201632045

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Ruthenium-catalysed C-alkylation of 1,3-dicarbonyl compounds with primary alcohols and synthesis of 3-keto-quinolines

Autor: Elena Cini, Maurizio Taddei, Marialaura Vecchio, Elena Petricci, Giuseppina I. Truglio

The mono-alkylation of 1,3-diketones using alcohols is possible in the presence of catalytic amounts of Ru(CO)(PPh3)3HCl and 10% mol of the Hantzsch ester. The borrowing hydrogen process between the catalyst and the dihydropyridine/pyridine couple pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df0608637ad3b9a3cbdbd1111ad369d
http://hdl.handle.net/11365/999276

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