Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Giuseppina Comito"'
Autor:
Nicla Lorito, Angela Subbiani, Alfredo Smiriglia, Marina Bacci, Francesca Bonechi, Laura Tronci, Elisabetta Romano, Alessia Corrado, Dario Livio Longo, Marta Iozzo, Luigi Ippolito, Giuseppina Comito, Elisa Giannoni, Icro Meattini, Alexandra Avgustinova, Paola Chiarugi, Angela Bachi, Andrea Morandi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1533-1559 (2024)
Abstract Triple-negative breast cancer (TNBC) has limited therapeutic options, is highly metastatic and characterized by early recurrence. Lipid metabolism is generally deregulated in TNBC and might reveal vulnerabilities to be targeted or used as bi
Externí odkaz:
https://doaj.org/article/26b9a22084be452a971cbb8677650abc
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/2a2987790a31434081ec84bdc4801b5c
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Neoplastic tissues are composed not only by tumor cells but also by several non-transformed stromal cells, such as cancer-associated fibroblasts, endothelial and immune cells, that actively participate to tumor progression. Starting from the very beg
Externí odkaz:
https://doaj.org/article/cab4852aa9b24838bfd3e8c9a40e0f5b
Publikováno v:
Cells, Vol 10, Iss 12, p 3396 (2021)
The tumour microenvironment (TME) is now recognised as a hallmark of cancer, since tumour:stroma crosstalk supports the key steps of tumour growth and progression. The dynamic co-evolution of the tumour and stromal compartments may alter the surround
Externí odkaz:
https://doaj.org/article/d4ea5a269534403eb98c486db1a0d611
Autor:
Marina Bacci, Nicla Lorito, Luigi Ippolito, Matteo Ramazzotti, Simone Luti, Simone Romagnoli, Matteo Parri, Francesca Bianchini, Federica Cappellesso, Federico Virga, Qiong Gao, Bruno M. Simões, Elisabetta Marangoni, Lesley-Ann Martin, Giuseppina Comito, Manuela Ferracin, Elisa Giannoni, Massimiliano Mazzone, Paola Chiarugi, Andrea Morandi
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 104-118.e8 (2019)
Summary: Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancers. Despite its efficacy, ∼40% of women relapse with ET-resistant (ETR) disease. A global transcription analysis in ETR cells reveals a downreg
Externí odkaz:
https://doaj.org/article/86ccd14202b94343ae0f4bad941fca47
Autor:
Nicla Lorito, Marina Bacci, Alfredo Smiriglia, Michele Mannelli, Matteo Parri, Giuseppina Comito, Luigi Ippolito, Elisa Giannoni, Martina Bonechi, Matteo Benelli, Ilenia Migliaccio, Luca Malorni, Paola Chiarugi, Andrea Morandi
Publikováno v:
Cells, Vol 9, Iss 3, p 668 (2020)
The majority of breast cancers express the estrogen receptor (ER) and are dependent on estrogen for their growth and survival. Endocrine therapy (ET) is the standard of care for these tumors. However, a superior outcome is achieved in a subset of ER
Externí odkaz:
https://doaj.org/article/c885404807d0449fbe83933f4de94acc
Autor:
Renato Ribeiro-Viana, Elena Bonechi, Javier Rojo, Clara Ballerini, Giuseppina Comito, Barbara Richichi, Cristina Nativi
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1317-1324 (2014)
Vaccination strategies based on dendritic cells (DCs) armed with specific tumor antigens have been widely exploited due the properties of these immune cells in coordinating an innate and adaptive response. Here, we describe the convergent synthesis o
Externí odkaz:
https://doaj.org/article/82774213c0b14678a9dff4fcc0567609
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e38388 (2012)
Intratumoral hypoxia is a major obstacle in the development of effective cancer chemotherapy, decreasing the efficacy of anti-neoplastic drugs in several solid tumours. The hypoxic environment, through its master regulator hypoxia inducible factor-1
Externí odkaz:
https://doaj.org/article/853088937740478eb9fa895c2aae1d3b
Autor:
Paola Chiarugi, Elisa Giannoni, Andrea Morandi, Carlo V. Catapano, Pietro Spatafora, Sergio Serni, Giancarlo la Marca, Lavinia Ferrone, Roberta Damiano, Francesca Bianchini, Giada Sandrini, Elisa Pardella, Marina Bacci, Nicla Lorito, Francesca Virgilio, Assia Duatti, Marta Iozzo, Matteo Parri, Giuseppina Comito, Luigi Ippolito
Lactate is an abundant oncometabolite in the tumor environment. In prostate cancer, cancer-associated fibroblasts (CAF) are major contributors of secreted lactate, which can be taken up by cancer cells to sustain mitochondrial metabolism. However, ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8435eade5f4df88cae9ede099f87c150
https://doi.org/10.1158/0008-5472.c.6513861.v1
https://doi.org/10.1158/0008-5472.c.6513861.v1
Autor:
Paola Chiarugi, Elisa Giannoni, Andrea Morandi, Carlo V. Catapano, Pietro Spatafora, Sergio Serni, Giancarlo la Marca, Lavinia Ferrone, Roberta Damiano, Francesca Bianchini, Giada Sandrini, Elisa Pardella, Marina Bacci, Nicla Lorito, Francesca Virgilio, Assia Duatti, Marta Iozzo, Matteo Parri, Giuseppina Comito, Luigi Ippolito
Supplementary Data from Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ff92919502a5a633790bd096900162
https://doi.org/10.1158/0008-5472.22431285
https://doi.org/10.1158/0008-5472.22431285