Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Giuseppina, Di Stefano"'
Publikováno v:
Cells, Vol 13, Iss 18, p 1533 (2024)
Cancer cells can release EGF-like peptides, acquiring the capacity of autocrine stimulation via EGFR-mediated signaling. One of these peptides (HBEGF) was found to be released from a membrane-bound precursor protein and is critically implicated in th
Externí odkaz:
https://doaj.org/article/83e6b96da94b4200932f7706dea65181
Autor:
Alberto Loro, Margherita Beatrice Borg, Marco Battaglia, Angelo Paolo Amico, Roberto Antenucci, Paolo Benanti, Michele Bertoni, Luciano Bissolotti, Paolo Boldrini, Donatella Bonaiuti, Thomas Bowman, Marianna Capecci, Enrico Castelli, Loredana Cavalli, Nicoletta Cinone, Lucia Cosenza, Rita Di Censo, Giuseppina Di Stefano, Francesco Draicchio, Vincenzo Falabella, Mirko Filippetti, Silvia Galeri, Francesca Gimigliano, Mauro Grigioni, Marco Invernizzi, Johanna Jonsdottir, Carmelo Lentino, Perla Massai, Stefano Mazzoleni, Stefano Mazzon, Franco Molteni, Sandra Morelli, Giovanni Morone, Antonio Nardone, Daniele Panzeri, Maurizio Petrarca, Federico Posteraro, Andrea Santamato, Lorenza Scotti, Michele Senatore, Stefania Spina, Elisa Taglione, Giuseppe Turchetti, Valentina Varalta, Alessandro Picelli, Alessio Baricich
Publikováno v:
Brain Sciences, Vol 13, Iss 1, p 92 (2023)
Background: Balance impairment is a common disability in post-stroke survivors, leading to reduced mobility and increased fall risk. Robotic gait training (RAGT) is largely used, along with traditional training. There is, however, no strong evidence
Externí odkaz:
https://doaj.org/article/b5dbaf80412b4b05a4fe658234998ae6
Autor:
Fabrizio Schipani, Marcella Manerba, Roberto Marotta, Laura Poppi, Arianna Gennari, Francesco Rinaldi, Andrea Armirotti, Fulvia Farabegoli, Marinella Roberti, Giuseppina Di Stefano, Walter Rocchia, Stefania Girotto, Nicola Tirelli, Andrea Cavalli
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8338 (2022)
The cytotoxic action of anticancer drugs can be potentiated by inhibiting DNA repair mechanisms. RAD51 is a crucial protein for genomic stability due to its critical role in the homologous recombination (HR) pathway. BRCA2 assists RAD51 fibrillation
Externí odkaz:
https://doaj.org/article/21950c5ffdd04e5b84a16581e5a3f2d7
Autor:
Marcella Manerba, Lorenza Di Ianni, Marzia Govoni, Antonietta Comparone, Giuseppina Di Stefano
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202588 (2018)
mTOR kinase and the A isoform of lactate dehydrogenase (LDH-A) are key players controlling the metabolic characteristics of cancer cells. By using cultured human breast cells as a "metabolic tumor" model, we attempted to explore the correlation betwe
Externí odkaz:
https://doaj.org/article/8a727c6be80f4c339fb3c55736e3ea6b
Autor:
Isabella Pallavicini, Greta Bagnolini, Andrea Balboni, Marinella Roberti, Janet Robertson, Giuseppina Di Stefano, Fulvia Farabegoli, Sebastiano Peri, Jose Antonio Ortega, Saverio Minucci, D. Gioia, Federico Falchi, Domenico Milano, Francesca De Franco, Fabrizio Schipani, Roberto Pellicciari, Andrea Cavalli, Marcella Manerba, Stefania Girotto
Publikováno v:
Journal of Medicinal Chemistry
Synthetic lethality is an innovative framework for discovering novel anticancer drug candidates. One example is the use of PARP inhibitors (PARPi) in oncology patients with BRCA mutations. Here, we exploit a new paradigm based on the possibility of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56a9ce8f1a24b0337c5b7b86be9e4f0a
https://doi.org/10.1021/acs.jmedchem.9b01526
https://doi.org/10.1021/acs.jmedchem.9b01526
Autor:
Luca Giacinto Iacovino, Martina Rossi, Giuseppina Di Stefano, Valentina Rossi, Claudia Binda, Maurizio Brigotti, Fabio Tomaselli, Alberto Pietro Pasti, Fabrizio Dal Piaz, Stefano Cerini, Alejandro Hochkoeppler
Among the functions exerted by eukaryotic lactate dehydrogenases, it is of importance the generation of lactate in muscles subjected to fatigue or to limited oxygen availability, with both these conditions triggering a decrease of cellular pH. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6578c11d6733ed1572075ca9045a4eee
http://hdl.handle.net/11386/4803813
http://hdl.handle.net/11386/4803813
Autor:
Alberto Pietro Pasti, Valentina Rossi, Giuseppina Di Stefano, Maurizio Brigotti, Alejandro Hochkoeppler
Publikováno v:
Bioscience Reports
The aerobic energetic metabolism of eukaryotic cells relies on the glycolytic generation of pyruvate, which is subsequently channelled to the oxidative phosphorylation taking place in mitochondria. However, under conditions limiting oxidative phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f5ea8e27be9349a3fb13254297e2e4
https://hdl.handle.net/11585/890197
https://hdl.handle.net/11585/890197
Background: Tamoxifen is a widely used estrogen receptor inhibitor, whose clinical success is limited by the development of acquired resistance. This compound was also found to inhibit mitochondrial function, causing increased glycolysis and lactate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25330aa0b90e7193bd786b1bab494400
http://hdl.handle.net/11585/888973
http://hdl.handle.net/11585/888973
Autor:
Marcella Manerba, Stefania Girotto, Fabrizio Schipani, Nicola Tirelli, Arianna Gennari, Andrea Armirotti, Roberto Marotta, Walter Rocchia, Giuseppina Di Stefano, Andrea Cavalli, Francesco Rinaldi, Marinella Roberti
RAD51, a key player in the homologous recombination (HR) mechanism, is a critical protein to preserve genomic stability. BRCA2, upon DNA damage, promotes RAD51 fibrils disassembly and its nuclear recruitment.Here, we use BRC4, a peptide derived from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d08f380a2c2fc76b743cf92e0d1558
https://doi.org/10.1101/2021.02.03.429564
https://doi.org/10.1101/2021.02.03.429564
Autor:
Matteo Renzulli, Anna Maria Ierardi, Fabio Pellegrino, Gianpaolo Carrafiello, Melchiore Giganti, Giuseppina Di Stefano, Aldo Carnevale, Cristian Bonelli
Uterine fibroids are common benign tumors that affect the female reproductive tract. They are responsible for considerable morbidity and deterioration of life quality. The main advantages offered by mini invasive techniques are low grade of invasiven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c089ee082a3f1b058f7c24c6734ca6c1
https://hdl.handle.net/11392/2455684
https://hdl.handle.net/11392/2455684