Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Giuseppe Tosto"'
Autor:
Vladislav Volosov, Santina Bevilacqua, Laura Anoldo, Giuseppe Tosto, Enzo Fontana, Alfio-lip Russo, Claudio Fiegna, Enrico Sangiorgi, Andrea Natale Tallarico
Publikováno v:
Micromachines, Vol 15, Iss 7, p 872 (2024)
This paper investigates the threshold voltage shift (ΔVTH) induced by positive bias temperature instability (PBTI) in silicon carbide (SiC) power MOSFETs. By analyzing ΔVTH under various gate stress voltages (VGstress) at 150 °C, distinct mechanis
Externí odkaz:
https://doaj.org/article/672f0d33bc154624acc403cea5af402f
Autor:
Tohid Siddiqui, Mehmet Ilyas Cosacak, Stanislava Popova, Prabesh Bhattarai, Elanur Yilmaz, Annie J. Lee, Yuhao Min, Xue Wang, Mariet Allen, Özkan İş, Zeynep Tansu Atasavum, Natalia Rodriguez-Muela, Badri N. Vardarajan, Delaney Flaherty, Andrew F. Teich, Ismael Santa-Maria, Uwe Freudenberg, Carsten Werner, Giuseppe Tosto, Richard Mayeux, Nilüfer Ertekin-Taner, Caghan Kizil
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract Neurogenesis, crucial for brain resilience, is reduced in Alzheimer’s disease (AD) that induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring neurogenesis could counteract neurodegenerative pathology.
Externí odkaz:
https://doaj.org/article/bebfc2431c024aae887659ececd580cc
Autor:
Min Qiao, Annie J. Lee, Dolly Reyes‐Dumeyer, Giuseppe Tosto, Kelley Faber, Alison Goate, Alan Renton, Michael Chao, Brad Boeve, Carlos Cruchaga, Margaret Pericak‐Vance, Jonathan L. Haines, Roger Rosenberg, Debby Tsuang, Robert A. Sweet, David A. Bennett, Robert S. Wilson, Tatiana Foroud, Richard Mayeux, Badri N. Vardarajan
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 5, Pp 744-756 (2023)
Abstract Objective To compute penetrance and recurrence risk using a genome‐wide PRS (including and excluding the APOE region) in families with Alzheimer's disease. Methods Genotypes from the National Institute on Aging Late‐Onset Alzheimer's Dis
Externí odkaz:
https://doaj.org/article/ca34451dd2fe4c19b1a16a4280fe7a72
Autor:
Minghua Liu, Farid Khasiyev, Sanjeev Sariya, Antonio Spagnolo‐Allende, Danurys L Sanchez, Howard Andrews, Qiong Yang, Alexa Beiser, Ye Qiao, Emy A Thomas, Jose Rafael Romero, Tatjana Rundek, Adam M Brickman, Jennifer J Manly, Mitchell SV Elkind, Sudha Seshadri, Christopher Chen, Saima Hilal, Bruce A Wasserman, Giuseppe Tosto, Myriam Fornage, Jose Gutierrez
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Background Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Traditional vascular risk factors have been associated with BADs, but whether there may be genetic determinants of BA
Externí odkaz:
https://doaj.org/article/65327b53f6404d6b816e60899153419f
Autor:
Daniel Felsky, Ismael Santa-Maria, Mehmet Ilyas Cosacak, Leon French, Julie A. Schneider, David A. Bennett, Philip L. De Jager, Caghan Kizil, Giuseppe Tosto
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105938- (2023)
Identifying ancestry-specific molecular profiles of late-onset Alzheimer's Disease (LOAD) in brain tissue is crucial to understand novel mechanisms and develop effective interventions in non-European, high-risk populations. We performed gene differen
Externí odkaz:
https://doaj.org/article/09de6a2816c94296a3ffd83441c8391c
Autor:
Mehmet Ilyas Cosacak, Prabesh Bhattarai, Philip L. De Jager, Vilas Menon, Giuseppe Tosto, Caghan Kizil
Publikováno v:
Cells, Vol 11, Iss 11, p 1807 (2022)
Neurogenesis is significantly reduced in Alzheimer’s disease (AD) and is a potential therapeutic target. Contrary to humans, a zebrafish can regenerate its diseased brain, and thus is ideal for studying neurogenesis. To compare the AD-related molec
Externí odkaz:
https://doaj.org/article/79850aaec113457b87589be95d66c8c6
Autor:
Tohid Siddiqui, Prabesh Bhattarai, Stanislava Popova, Mehmet Ilyas Cosacak, Sanjeev Sariya, Yixin Zhang, Richard Mayeux, Giuseppe Tosto, Caghan Kizil
Publikováno v:
Cells, Vol 10, Iss 10, p 2748 (2021)
Neurogenesis decreases in Alzheimer’s disease (AD) patients, suggesting that restoring the normal neurogenic response could be a disease modifying intervention. To study the mechanisms of pathology-induced neuro-regeneration in vertebrate brains, z
Externí odkaz:
https://doaj.org/article/0f577cd1263a49538ea97d57cc823b42
Autor:
Sanjeev Sariya, Joseph H. Lee, Richard Mayeux, Badri N. Vardarajan, Dolly Reyes-Dumeyer, Jennifer J. Manly, Adam M. Brickman, Rafael Lantigua, Martin Medrano, Ivonne Z. Jimenez-Velazquez, Giuseppe Tosto
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
BackgroundImputation has become a standard approach in genome-wide association studies (GWAS) to infer in silico untyped markers. Although feasibility for common variants imputation is well established, we aimed to assess rare and ultra-rare variants
Externí odkaz:
https://doaj.org/article/f44de7082229410e9de2141980b23398
Autor:
Seonjoo Lee, Molly E Zimmerman, Atul Narkhede, Sara E Nasrabady, Giuseppe Tosto, Irene B Meier, Tammie L S Benzinger, Daniel S Marcus, Anne M Fagan, Nick C Fox, Nigel J Cairns, David M Holtzman, Virginia Buckles, Bernardino Ghetti, Eric McDade, Ralph N Martins, Andrew J Saykin, Colin L Masters, John M Ringman, Stefan Fӧrster, Peter R Schofield, Reisa A Sperling, Keith A Johnson, Jasmeer P Chhatwal, Stephen Salloway, Stephen Correia, Clifford R Jack, Michael Weiner, Randall J Bateman, John C Morris, Richard Mayeux, Adam M Brickman, Dominantly Inherited Alzheimer Network
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0195838 (2018)
INTRODUCTION:White matter hyperintensity (WMH) volume on MRI is increased among presymptomatic individuals with autosomal dominant mutations for Alzheimer's disease (AD). One potential explanation is that WMH, conventionally considered a marker of ce
Externí odkaz:
https://doaj.org/article/ed7c9a6ecadf43f2bcdf1faf91145ddd
Autor:
Christiane Reitz, Giuseppe Tosto, Richard Mayeux, Jose A Luchsinger, NIA-LOAD/NCRAD Family Study Group, Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50354 (2012)
BACKGROUND:Recent studies showed that polymorphisms in the Fat and Obesity-Associated (FTO) gene have robust effects on obesity, obesity-related traits and endophenotypes associated with Alzheimer's disease (AD). METHODS:We used 1,877 Caucasian cases
Externí odkaz:
https://doaj.org/article/d7ffe3b8d3c04699bb2a64face9af7d7