Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Giuseppe Sciumè"'
Autor:
Rosa Molfetta, Mario Lecce, Nadia D. Milito, Erisa Putro, Giuseppe Pietropaolo, Caterina Marangio, Gianluca Scarno, Marta Moretti, Enrico De Smaele, Tiziana Santini, Giovanni Bernardini, Giuseppe Sciumè, Angela Santoni, Rossella Paolini
Publikováno v:
Cell Death and Disease, Vol 14, Iss 9, Pp 1-13 (2023)
Abstract Mast cells (MCs) are multifaceted innate immune cells often present in the tumor microenvironment (TME). Several recent findings support their contribution to the transition from chronic inflammation to cancer. However, MC-derived mediators
Externí odkaz:
https://doaj.org/article/2ea10411882447939b7d4f8be5646876
Autor:
Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z. Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R. Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciumè, Vanessa M. D’Costa, Michele Ardolino, Lisheng Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChemotherapy remains the mainstay treatment for triple-negative breast cancer (TNBC) due to the lack of specific targets. Given a modest response of immune checkpoint inhibitors in TNBC patients, improving immunotherapy is an urgent and c
Externí odkaz:
https://doaj.org/article/10213cd0c20d41adb4e2783bba54bf80
Autor:
Stefano Garofalo, Germana Cocozza, Alessandro Mormino, Giovanni Bernardini, Eleonora Russo, Donald Ielpo, Diego Andolina, Rossella Ventura, Katiuscia Martinello, Massimiliano Renzi, Sergio Fucile, Mattia Laffranchi, Eva Piano Mortari, Rita Carsetti, Giuseppe Sciumè, Silvano Sozzani, Angela Santoni, Marie-Eve Tremblay, Richard M. Ransohoff, Cristina Limatola
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The mechanisms of communication between the brain and the immune cells are still largely unclear. Here, we characterize the populations of resident natural killer (NK) cells and innate lymphoid cells (ILC) 1 in the meningeal dura layer of ad
Externí odkaz:
https://doaj.org/article/0211a315673a47ed8fe4e14ffd46fcd7
Autor:
Stéphane Urcun, Davide Baroli, Pierre-Yves Rohan, Wafa Skalli, Vincent Lubrano, Stéphane P.A. Bordas, Giuseppe Sciumè
Publikováno v:
Brain Multiphysics, Vol 4, Iss , Pp 100067- (2023)
We propose a novel image-informed glioblastoma mathematical model within a reactive multiphase poromechanical framework. Poromechanics offers to model in a coupled manner the interplay between tissue deformation and pressure-driven fluid flows, these
Externí odkaz:
https://doaj.org/article/a9a67b2eec1d4bf19b50a8fa25033eff
Autor:
Cinzia Fionda, Silvia Ruggeri, Giuseppe Sciumè, Mattia Laffranchi, Isabella Quinti, Cinzia Milito, Paolo Palange, Ilaria Menichini, Silvano Sozzani, Luigi Frati, Angela Gismondi, Angela Santoni, Helena Stabile
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural Killer (NK) cells are key innate effectors of antiviral immune response, and their activity changes in ageing and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated the age-related changes of NK cell
Externí odkaz:
https://doaj.org/article/dd4ab049a2bf4e2a95d219e4f52c73fd
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The precise control of cytokine production by innate lymphoid cells (ILCs) and their T cell adaptive system counterparts is critical to mounting a proper host defense immune response without inducing collateral damage and autoimmunity. Unlike T cells
Externí odkaz:
https://doaj.org/article/a384158720d147568e23778c7954183a
Autor:
Stéphane Urcun, Pierre-Yves Rohan, Wafa Skalli, Pierre Nassoy, Stéphane P A Bordas, Giuseppe Sciumè
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254512 (2021)
Spheroids encapsulated within alginate capsules are emerging as suitable in vitro tools to investigate the impact of mechanical forces on tumor growth since the internal tumor pressure can be retrieved from the deformation of the capsule. Here we foc
Externí odkaz:
https://doaj.org/article/dd81594c59a14be5a265d7b7b99e8402
Autor:
Cristina Capuano, Chiara Pighi, Simone Battella, Fabio Pulcinelli, Cristina Santoro, Antonietta Ferretti, Ombretta Turriziani, Davide De Federicis, Cinzia Fionda, Giuseppe Sciumè, Ricciarda Galandrini, Gabriella Palmieri
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 625 (2022)
In vivo establishment and long-term persistence of a heterogeneous memory or an adaptive NK cell pool represents a functional adaptation to human cytomegalovirus (HCMV) infection in humans. Memory NK cells are commonly identified by lack of the FcεR
Externí odkaz:
https://doaj.org/article/c07965110d39436fa2caf3d71cf43203
Autor:
Alessio Grimaldi, Giuseppe Pietropaolo, Helena Stabile, Andrea Kosta, Cristina Capuano, Angela Gismondi, Angela Santoni, Giuseppe Sciumè, Cinzia Fionda
Publikováno v:
Cells, Vol 10, Iss 10, p 2742 (2021)
Innate lymphoid cells (ILCs) are innate lymphocytes playing essential functions in protection against microbial infections and participate in both homeostatic and pathological contexts, including tissue remodeling, cancer, and inflammatory disorders.
Externí odkaz:
https://doaj.org/article/911fa212af80427f98f6d70f7e42b72a
Autor:
Laura Vian, Mimi T. Le, Nathalia Gazaniga, Jacqueline Kieltyka, Christine Liu, Giuseppe Pietropaolo, Stefania Dell'Orso, Stephen R. Brooks, Yasuko Furumoto, Craig J. Thomas, John J. O'Shea, Giuseppe Sciumè, Massimo Gadina
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Janus kinase (JAK) inhibitors are widely used in the treatment of multiple autoimmune and inflammatory diseases. Immunologic and transcriptomic profiling have revealed major alterations on natural killer (NK) cell homeostasis associated with JAK inhi
Externí odkaz:
https://doaj.org/article/fa9c74c3391a49eca27412b17c27ed59