Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Giuseppe N Giordano"'
Autor:
Agnete T Lundgaard, Frédéric Burdet, Troels Siggaard, David Westergaard, Danai Vagiaki, Lisa Cantwell, Timo Röder, Dorte Vistisen, Thomas Sparsø, Giuseppe N Giordano, Mark Ibberson, Karina Banasik, Søren Brunak
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011403 (2023)
Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to en
Externí odkaz:
https://doaj.org/article/e9bcb10580014711a1cad88ec783e624
Autor:
Naeimeh Atabaki-Pasdar, Mattias Ohlsson, Ana Viñuela, Francesca Frau, Hugo Pomares-Millan, Mark Haid, Angus G Jones, E Louise Thomas, Robert W Koivula, Azra Kurbasic, Pascal M Mutie, Hugo Fitipaldi, Juan Fernandez, Adem Y Dawed, Giuseppe N Giordano, Ian M Forgie, Timothy J McDonald, Femke Rutters, Henna Cederberg, Elizaveta Chabanova, Matilda Dale, Federico De Masi, Cecilia Engel Thomas, Kristine H Allin, Tue H Hansen, Alison Heggie, Mun-Gwan Hong, Petra J M Elders, Gwen Kennedy, Tarja Kokkola, Helle Krogh Pedersen, Anubha Mahajan, Donna McEvoy, Francois Pattou, Violeta Raverdy, Ragna S Häussler, Sapna Sharma, Henrik S Thomsen, Jagadish Vangipurapu, Henrik Vestergaard, Leen M 't Hart, Jerzy Adamski, Petra B Musholt, Soren Brage, Søren Brunak, Emmanouil Dermitzakis, Gary Frost, Torben Hansen, Markku Laakso, Oluf Pedersen, Martin Ridderstråle, Hartmut Ruetten, Andrew T Hattersley, Mark Walker, Joline W J Beulens, Andrea Mari, Jochen M Schwenk, Ramneek Gupta, Mark I McCarthy, Ewan R Pearson, Jimmy D Bell, Imre Pavo, Paul W Franks
Publikováno v:
PLoS Medicine, Vol 17, Iss 6, p e1003149 (2020)
BackgroundNon-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage
Externí odkaz:
https://doaj.org/article/a99f2812d7bb4af9aa894b7e0bf320bd
Autor:
Morgan Obura, Joline W J Beulens, Roderick Slieker, Anitra D M Koopman, Trynke Hoekstra, Giel Nijpels, Petra Elders, Robert W Koivula, Azra Kurbasic, Markku Laakso, Tue H Hansen, Martin Ridderstråle, Torben Hansen, Imre Pavo, Ian Forgie, Bernd Jablonka, Hartmut Ruetten, Andrea Mari, Mark I McCarthy, Mark Walker, Alison Heggie, Timothy J McDonald, Mandy H Perry, Federico De Masi, Søren Brunak, Anubha Mahajan, Giuseppe N Giordano, Tarja Kokkola, Emmanouil Dermitzakis, Ana Viñuela, Oluf Pedersen, Jochen M Schwenk, Jurek Adamski, Harriet J A Teare, Ewan R Pearson, Paul W Franks, Leen M 't Hart, Femke Rutters, IMI-DIRECT Consortium
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
AimSubclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-
Externí odkaz:
https://doaj.org/article/fa28468aa1134da49de7b42ba239579c
Autor:
Carl Delfin, Iulian Dragan, Dmitry Kuznetsov, Juan Fernandez Tajes, Femke Smit, Daniel E. Coral, Ali Farzaneh, André Haugg, Andreas Hungele, Anne Niknejad, Christopher Hall, Daan Jacobs, Diana Marek, Diane P. Fraser, Dorothee Thuillier, Fariba Ahmadizar, Florence Mehl, Francois Pattou, Frederic Burdet, Gareth Hawkes, Ilja C. W. Arts, Jordi Blanch, Johan Van Soest, José-Manuel Fernández-Real, Juergen Boehl, Katharina Fink, Marleen M. J. van Greevenbroek, Maryam Kavousi, Michiel Minten, Nicole Prinz, Niels Ipsen, Paul W. Franks, Rafael Ramos, Reinhard W. Holl, Scott Horban, Talita Duarte-Salles, Van Du T. Tran, Violeta Raverdy, Yenny Leal, Adam Lenart, Ewan Pearson, Thomas Sparsø, Giuseppe N. Giordano, Vassilios Ioannidis, Keng Soh, Timothy M. Frayling, Carel W. Le Roux, Mark Ibberson
Publikováno v:
Life, Vol 14, Iss 2, p 262 (2024)
Obesity is considered by many as a lifestyle choice rather than a chronic progressive disease. The Innovative Medicines Initiative (IMI) SOPHIA (Stratification of Obesity Phenotypes to Optimize Future Obesity Therapy) project is part of a momentum sh
Externí odkaz:
https://doaj.org/article/343e0c783d8e4fc48237db8466dd4363
Autor:
Pascal M. Mutie, Hugo Pomares-Millan, Naeimeh Atabaki-Pasdar, Nina Jordan, Rachel Adams, Nicole L. Daly, Juan Fernandes Tajes, Giuseppe N. Giordano, Paul W. Franks
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Prediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diab
Externí odkaz:
https://doaj.org/article/606683e303cd49249b14a925acdda959
Predicting Sensitivity to Adverse Lifestyle Risk Factors for Cardiometabolic Morbidity and Mortality
Autor:
Hugo Pomares-Millan, Alaitz Poveda, Naemieh Atabaki-Pasdar, Ingegerd Johansson, Jonas Björk, Mattias Ohlsson, Giuseppe N. Giordano, Paul W. Franks
Publikováno v:
Nutrients, Vol 14, Iss 15, p 3171 (2022)
People appear to vary in their susceptibility to lifestyle risk factors for cardiometabolic disease; determining a priori who is most sensitive may help optimize the timing, design, and delivery of preventative interventions. We aimed to ascertain a
Externí odkaz:
https://doaj.org/article/a3a2b9971287436488c46bbf72554ae4
Autor:
Hugo Pomares-Millan, Naeimeh Atabaki-Pasdar, Daniel Coral, Ingegerd Johansson, Giuseppe N. Giordano, Paul W. Franks
Publikováno v:
Nutrients, Vol 14, Iss 6, p 1218 (2022)
Assessing the causal effects of individual dietary macronutrients and cardiometabolic disease is challenging because distinguish direct effects from those mediated or confounded by other factors is difficult. To estimate these effects, intake of prot
Externí odkaz:
https://doaj.org/article/2b6b0121e4dd43ea85428d22f9841e91
Autor:
Rebeca Eriksen, Isabel Garcia Perez, Joram M. Posma, Mark Haid, Sapna Sharma, Cornelia Prehn, Louise E. Thomas, Robert W. Koivula, Roberto Bizzotto, Andrea Mari, Giuseppe N. Giordano, Imre Pavo, Jochen M. Schwenk, Federico De Masi, Konstantinos D. Tsirigos, Søren Brunak, Ana Viñuela, Anubha Mahajan, Timothy J. McDonald, Tarja Kokkola, Femke Rutter, Harriet Teare, Tue H. Hansen, Juan Fernandez, Angus Jones, Chris Jennison, Mark Walker, Mark I. McCarthy, Oluf Pedersen, Hartmut Ruetten, Ian Forgie, Jimmy D. Bell, Ewan R. Pearson, Paul W. Franks, Jerzy Adamski, Elaine Holmes, Gary Frost
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102932- (2020)
Summary: Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. He
Externí odkaz:
https://doaj.org/article/91a6b1da9f4c4ad291a70d42d358d715
Autor:
Pascal M. Mutie, Hugo Pomares-Milan, Naeimeh Atabaki-Pasdar, Daniel Coral, Hugo Fitipaldi, Neli Tsereteli, Juan Fernandez Tajes, Paul W. Franks, Giuseppe N. Giordano
Publikováno v:
Diabetologia. 66:321-335
Aims/hypothesis Excess adiposity is differentially associated with increased risk of cardiometabolic disease in men and women, according to observational studies. Causal inference studies largely assume a linear relationship between BMI and cardiomet
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity.
Externí odkaz:
https://doaj.org/article/22df7075474b4bc49af7c4254eff9400