Computational studies on sirtuins from Trypanosoma cruzi: structures, conformations and interactions with phytochemicals.

Autor: Lionel Sacconnay, Melissa Angleviel, Giuseppe Marco Randazzo, Marcos Marçal Ferreira Queiroz, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pierre-Alain Carrupt, Alessandra Nurisso

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2689 (2014)

BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth

Externí odkaz: https://doaj.org/article/f704bf9983f84b8698f64c03a2e2ad8a

Synthesis of a selective HDAC6 inhibitor active in neuroblasts

Autor: Vincent Zwick, Giuseppe Marco Randazzo, Claudia A. Simões-Pires, Muriel Cuendet, Philippe Bertrand, Carolina dos Santos Passos, Nadine Martinet, Charlotte Petit, Alessandra Nurisso

Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, Vol. 26, No 20 (2016) pp. 4955-4959

In recent years, the role of HDAC6 in neurodegeneration has been partially elucidated, which led some authors to propose HDAC6 inhibitors as a therapeutic strategy to treat neurodegenerative diseases. In an effort to develop a selective HDAC6 inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7b299e25e2702caf3f9cfc48225296
https://doi.org/10.1016/j.bmcl.2016.09.011

The CARSO (Computer Aided Response Surface Optimization) Procedure in Optimization Studies

Autor: Sergio Clementi, Diego Decastri, Massimo Baroni, Lucia Gardossi, Cynthia Ebert, Paolo Benedetti, Matteo Bazzurri, Danilo Chiocchini, Mauro Fernandi, Giuseppe Marco Randazzo

Publikováno v: Applied Mathematics. :1947-1956

The paper illustrates innovative ways of using the CARSO (Computer Aided Response Surface Optimization) procedure for response surfaces analyses derived by DCM4 experimental designs in multivariate spaces. Within this method, we show a new feature fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda50801880b932ddd35076f71571ea1
https://doi.org/10.4236/am.2015.611172

Indirect quantitative structure-retention relationship for steroid identification: A chemometric challenge at 'Chimiometrie 2016'

Autor: Philippe Courcoux, Yves Lijour, Giuseppe Marco Randazzo, Serge Rudaz, Pierre Dardenne, Evelyne Vigneau, Corentin Harrouet, Julien Boccard

Publikováno v: Chemometrics and Intelligent Laboratory Systems
Chemometrics and Intelligent Laboratory Systems, Elsevier, 2017, 160, pp.52-58. ⟨10.1016/j.chemolab.2016.11.010⟩
Chemometrics and Intelligent Laboratory Systems, Vol. 160 (2017) pp. 52-58

A chemometric challenge was proposed during the "Chimiometrie" congress 2016, held in Namur, Belgium, on 17–20 January. The aim of this contest was to challenge the ability of congress participants to build indirect Quantitative Structure-Retention

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e32739210b7b457d279591d231b1b9
https://hal.archives-ouvertes.fr/hal-01600230

A Rational Approach for the Identification of Non-Hydroxamate HDAC6-Selective Inhibitors

Autor: Carolina dos Santos Passos, Nathalie Deschamps, Pierre-Alain Carrupt, Alessandra Nurisso, Laura Goracci, Claudia A. Simões-Pires, Charlotte Petit, Giuseppe Marco Randazzo

Publikováno v: Scientific Reports

The human histone deacetylase isoform 6 (HDAC6) has been demonstrated to play a major role in cell motility and aggresome formation, being interesting for the treatment of multiple tumour types and neurodegenerative conditions. Currently, most HDAC i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d40e435c25ef28c66c6dd74f66e903
http://europepmc.org/articles/PMC4941420