Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Giuseppe Manfroni"'
Autor:
Deborah Palazzotti, Martina Sguilla, Giuseppe Manfroni, Violetta Cecchetti, Andrea Astolfi, Maria Letizia Barreca
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 661 (2024)
Small molecules that specifically target viral polymerases—crucial enzymes governing viral genome transcription and replication—play a pivotal role in combating viral infections. Presently, approved polymerase inhibitors cover nine human viruses,
Externí odkaz:
https://doaj.org/article/1889c35aa0c342a1ac2b9e0dce2845a4
Autor:
Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 584-597 (2020)
NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is availab
Externí odkaz:
https://doaj.org/article/5d409e0254d546e4bebeb4a36d0593e8
Autor:
Serena Massari, Angela Corona, Simona Distinto, Jenny Desantis, Alessia Caredda, Stefano Sabatini, Giuseppe Manfroni, Tommaso Felicetti, Violetta Cecchetti, Christophe Pannecouque, Elias Maccioni, Enzo Tramontano, Oriana Tabarrini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 55-74 (2019)
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2
Externí odkaz:
https://doaj.org/article/b4e8f0c07ca642ccb28f0ad18fbcbe9c
Autor:
Rafaela Milan Bonotto, Francesco Bonì, Mario Milani, Antonio Chaves-Sanjuan, Silvia Franze, Francesca Selmin, Tommaso Felicetti, Martino Bolognesi, Soultana Konstantinidou, Monica Poggianella, Chantal L. Márquez, Federica Dattola, Monica Zoppè, Giuseppe Manfroni, Eloise Mastrangelo, Alessandro Marcello
Publikováno v:
Viruses, Vol 14, Iss 6, p 1157 (2022)
Pyridobenzothiazolone derivatives are a promising class of broad-spectrum antivirals. However, the mode of action of these compounds remains poorly understood. The HeE1-17Y derivative has already been shown to be a potent compound against a variety o
Externí odkaz:
https://doaj.org/article/b90d49d34ce949a9a2ae978d6def6752
Autor:
Ilaria Caracciolo, Erick Mora-Cardenas, Chiara Aloise, Tea Carletti, Ludovica Segat, Maria Sole Burali, Alexsia Chiarvesio, Vivianna Totis, Tatjana Avšič-Županc, Eloise Mastrangelo, Giuseppe Manfroni, Pierlanfranco D'Agaro, Alessandro Marcello
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0008156 (2020)
Surveillance of Usutu virus is crucial to prevent future outbreaks both in Europe and in other countries currently naïve to the infection, such as the Americas. This goal remains difficult to achieve, notably because of the lack of large-scale cohor
Externí odkaz:
https://doaj.org/article/bfa4b3db245a48a79fde3925293fea19
Autor:
Rolando Cannalire, Gianmarco Mangiaterra, Tommaso Felicetti, Andrea Astolfi, Nicholas Cedraro, Serena Massari, Giuseppe Manfroni, Oriana Tabarrini, Salvatore Vaiasicca, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7037 (2020)
Tackling antimicrobial resistance (AMR) represents a social responsibility aimed at renewing the antimicrobial armamentarium and identifying novel therapeutical approaches. Among the possible strategies, efflux pumps inhibition offers the advantage t
Externí odkaz:
https://doaj.org/article/08be49557df64b43857ae72bb0206d4f
Autor:
Jenny Desantis, Serena Massari, Angela Corona, Andrea Astolfi, Stefano Sabatini, Giuseppe Manfroni, Deborah Palazzotti, Violetta Cecchetti, Christophe Pannecouque, Enzo Tramontano, Oriana Tabarrini
Publikováno v:
Molecules, Vol 25, Iss 5, p 1183 (2020)
Despite great efforts have been made in the prevention and therapy of human immunodeficiency virus (HIV-1) infection, however the difficulty to eradicate latent viral reservoirs together with the emergence of multi-drug-resistant strains require the
Externí odkaz:
https://doaj.org/article/eb2a061e05284ebf8e7d726841366e2a
Autor:
Diana Machado, Laura Fernandes, Sofia S. Costa, Rolando Cannalire, Giuseppe Manfroni, Oriana Tabarrini, Isabel Couto, Stefano Sabatini, Miguel Viveiros
Publikováno v:
PeerJ, Vol 5, p e3168 (2017)
Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this
Externí odkaz:
https://doaj.org/article/97b8a42d38c8427db80f98deba42f3f1
Autor:
Giuseppe Manfroni, Francesco Meschini, Ferdinando Costantino, Oriana Tabarrini, Violetta Cecchetti
Publikováno v:
ARKIVOC, Vol 2011, Iss 9, Pp 165-176 (2011)
Externí odkaz:
https://doaj.org/article/e2c3bb65d1064a0aaf755d66eb1f940f
Autor:
Chiara Acchioni, Marta Acchioni, Flavia Mancini, Antonello Amendola, Giulia Marsili, Valentina Tirelli, Chin Piaw Gwee, Kitti Wing-Ki Chan, Silvia Sandini, Monica Bisbocci, Mohamed Mysara, Mahmoud ElHefnawi, Massimo Sanchez, Giulietta Venturi, Maria Letizia Barreca, Giuseppe Manfroni, Alberto Bresciani, Subhash G. Vasudevan, Marco Sgarbanti
Publikováno v:
Virology. 583:1-13