Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis

Autor: Alejandro López-Tobón, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco De Simone, Isabel Liste-Noya, Giuseppe Macino, Massimiliano Pagani, Elena Cattaneo, Giuseppe Testa

Publikováno v: Stem Cell Reports, Vol 13, Iss 5, Pp 847-861 (2019)

Summary: The regulation of the proliferation and polarity of neural progenitors is crucial for the development of the brain cortex. Animal studies have implicated glycogen synthase kinase 3 (GSK3) as a pivotal regulator of both proliferation and pola

Externí odkaz: https://doaj.org/article/59aa1d8855cf47e49b953ab485034343

Microarray dataset of Jurkat cells following miR-93 over-expression

Autor: Silvia Gioiosa, Lorena Verduci, Gianluca Azzalin, Claudia Carissimi, Valerio Fulci, Giuseppe Macino

Publikováno v: Data in Brief, Vol 8, Iss , Pp 575-578 (2016)

The dataset presented here represents a microarray experiment of Jurkat cell line over-expressing miR-93 after lentiviral transgenic construct transduction. Three biological replicates have been performed.We further provide normalized and processed d

Externí odkaz: https://doaj.org/article/8699a1ce11644f2a9626d94000849f34

Comprehensive RNA dataset of AGO2 associated RNAs in Jurkat cells following miR-21 over-expression

Autor: Claudia Carissimi, Teresa Colombo, Gianluca Azzalin, Emanuela Cipolletta, Ilaria Laudadio, Giuseppe Macino, Valerio Fulci

Publikováno v: Data in Brief, Vol 7, Iss , Pp 604-606 (2016)

We set out to identify miR-21 targets in Jurkat cells using a high-throughput biochemical approach (10.1016/j.biochi.2014.09.021 [1]). Using a specific monoclonal antibody raised against AGO2, RISC complexes were immunopurified in Jurkat cells over-e

Externí odkaz: https://doaj.org/article/caf232b704514bf7a853ea9f9f19f237

TP53 regulates miRNA association with AGO2 to remodel the miRNA–mRNA interaction network

Autor: Valerio Fulci, Giuseppe Macino, Jonathan Krell, Claudia Carissimi, Teresa Colombo, Aleksandra Dabrowska, Justin Stebbing, Leandro Castellano, Victoria Harding, Adam E Frampton, Alexander de Giorgio

Publikováno v: Genome Research. 26:331-341

DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d603f7ee75d2aa571da24373bbf500c
https://doi.org/10.1101/gr.191759.115

The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex

Autor: Sabrina Strano, Maria Ferraiuolo, Giovanni Blandino, Lorena Verduci, Andrea Sacconi, Jlenia Vitale, Giuseppe Macino, Nikolaus Rajewsky, Teresa Colombo, Federica Ganci, Paola Paci

Publikováno v: Genome Biology
Genome biology
18 (2017). doi:10.1186/s13059-017-1368-y
info:cnr-pdr/source/autori:Verduci L.; Ferraiuolo M.; Sacconi A.; Ganci F.; Vitale J.; Colombo T.; Paci P.; Strano S.; Macino G.; Rajewsky N.; Blandino G./titolo:The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53%2FYAP%2FTEAD transcription-competent complex/doi:10.1186%2Fs13059-017-1368-y/rivista:Genome biology (Print)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:18
Genome Biology, Vol 18, Iss 1, Pp 1-24 (2017)

Background Circular RNAs are a class of endogenous RNAs with various functions in eukaryotic cells. Worthy of note, circular RNAs play a critical role in cancer. Currently, nothing is known about their role in head and neck squamous cell carcinoma (H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d344f022e5d98d1a7f192c8f3d1b9387
https://doi.org/10.1186/s13059-017-1368-y