Biospeciation of Potential Vanadium Drugs of Acetylacetonate in the Presence of Proteins

Autor: Giuseppe Sciortino, Valeria Ugone, Daniele Sanna, Giuseppe Lubinu, Simone Ruggiu, Jean-Didier Maréchal, Eugenio Garribba

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Among vanadium compounds with potential medicinal applications, [VIVO(acac)2] is one of the most promising for its antidiabetic and anticancer activity. In the organism, however, interconversion of the oxidation state to +III and +V and binding to pr

Externí odkaz: https://doaj.org/article/e6fc7c23013d44edaa3887ae1030a18f

Unveiling VIVO2+Binding Modes to Human Serum Albumins by an Integrated Spectroscopic–Computational Approach

Autor: Giuseppe Sciortino, Jean-Didier Maréchal, Giuseppe Lubinu, Daniele Sanna, Eugenio Garribba

Publikováno v: Chemistry (Weinh., Print) (2020). doi:10.1002/chem.202001492
info:cnr-pdr/source/autori:Sciortino G.; Sanna D.; Lubinu G.; Marechal J.-D.; Garribba E./titolo:Unveiling V(IV)O2+ Binding Modes to Human Serum Albumins by an Integrated Spectroscopic-Computational Approach/doi:10.1002%2Fchem.202001492/rivista:Chemistry (Weinh., Print)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume

Human serum albumin (HSA) is involved in the transport of metal ions and potential metallodrugs. Depending on the metal, several sites are available, among which are N-terminal (NTS) and multi-metal binding sites (MBS). Despite the large number of X-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238366c239d02c54b87600ab2c9ff7c6
https://doi.org/10.1002/chem.202001492

Biospeciation of Potential Vanadium Drugs of Acetylacetonate in the Presence of Proteins

Autor: Jean-Didier Maréchal, Simone Ruggiu, Daniele Sanna, Valeria Ugone, Eugenio Garribba, Giuseppe Sciortino, Giuseppe Lubinu

Publikováno v: Frontiers in Chemistry 8 (2020). doi:10.3389/fchem.2020.00345
info:cnr-pdr/source/autori:Sciortino, Giuseppe; Ugone, Valeria; Sanna, Daniele; Lubinu, Giuseppe; Ruggiu, Simone; Maréchal, Jean Didier; Garribba, Eugenio/titolo:Biospeciation of Potential Vanadium Drugs of Acetylacetonate in the Presence of Proteins/doi:10.3389%2Ffchem.2020.00345/rivista:Frontiers in Chemistry/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:8
Frontiers in Chemistry, Vol 8 (2020)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Frontiers in Chemistry

Among vanadium compounds with potential medicinal applications, [V IV O(acac)] is one of the most promising for its antidiabetic and anticancer activity. In the organism, however, interconversion of the oxidation state to +III and +V and binding to p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b223665b12ce8684222cea0ba433428

Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells

Autor: Eugenio Garribba, Daniele Sanna, Franc Perdih, Giuseppe Lubinu, Péter Buglyó, Jessica Palomba, Sándor Nagy

Publikováno v: Journal of medicinal chemistry (Online) 62 (2019): 654–664. doi:10.1021/acs.jmedchem.8b01330
info:cnr-pdr/source/autori:Daniele Sanna, Jessica Palomba, Giuseppe Lubinu, Péter Buglyó, Sándor Nagy, Franc Perdih, and Eugenio Garribba/titolo:Role of Ligands in the Uptake and Reduction of V(V) Complexes in Red Blood Cells/doi:10.1021%2Facs.jmedchem.8b01330/rivista:Journal of medicinal chemistry (Online)/anno:2019/pagina_da:654/pagina_a:664/intervallo_pagine:654–664/volume:62

The interaction with erythrocytes of four [V(V)O2L2]- complexes, with L = picolinate (pic), 5-cyanopicolinate (picCN), 3-aminopyrazine-2-carboxylate (przNH2), and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinonate (dhp), was studied. The thermodynamic stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4717c98b3fef5215450937d512cf4b
https://pubmed.ncbi.nlm.nih.gov/30576137

Polymeric Nanoparticles Encapsulating White Tea Extract for Nutraceutical Application

Autor: Giuseppe Lubinu, Nicolino Pala, Alberto Mariani, Pierluigi Madau, Vanna Sanna, Salvatore Nurra, Mario Sechi

Publikováno v: Journal of Agricultural and Food Chemistry. 63:2026-2032

With the aim to obtain controlled release and to preserve the antioxidant activity of the polyphenols, nanoencapsulation of white tea extract into polymeric nanoparticles (NPs) based on poly(ε-caprolactone) (PCL) and alginate was successfully perfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2da0bf130d7c30fb5a52d10b97b017
https://doi.org/10.1021/jf505850q