Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Giuseppe Gumina"'
Publikováno v:
Pharmacy, Vol 7, Iss 3, p 132 (2019)
As one of the earliest developed antimicrobial classes, sulfonamides remain important therapeutic options for the empiric and definitive treatment of various infectious diseases. In the general population, approximately 3−8% of patients are reporte
Externí odkaz:
https://doaj.org/article/cd1f7deb0868426d9e2517f9ad7d3daa
Autor:
Blair A. Weaver, Amy R. Messersmith, Will E. Lynch, Josh Carter, Giuseppe Gumina, Maria A. Chiacchio, Brent D. Feske
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 36:224-241
Puromycin is a peptidyl nucleoside endowed with significant antibiotic and anticancer properties, but also with an unfortunate nephrotoxic character that has hampered its use as a chemotherapeutic agent. Since hydrolysis of puromycin's amide to purom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69abf9b19a82f1795e4fa5399529525f
https://doi.org/10.1080/15257770.2016.1264590
https://doi.org/10.1080/15257770.2016.1264590
Publikováno v:
Chemical Data Collections. 2:49-55
We devised a synthetic scheme based on a Horner–Wadsworth–Emmons olefination followed by a stereoselective reduction in the attempt to synthesize a puromycin analog that cannot be metabolized to a known nephrotoxic 3′-aminonucleoside. This proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::826bc822d761fea1c8579b0124b754ad
https://doi.org/10.1016/j.cdc.2016.04.001
https://doi.org/10.1016/j.cdc.2016.04.001
Publikováno v:
Current medicinal chemistry. 26(28)
As a long-term degenerative disorder of the central nervous system that mostly affects older people, Parkinson’s disease is a growing health threat to our ever-aging population. Despite remarkable advances in our understanding of this disease, all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2b8b304d321a2eabe960a8952a70fb
https://pubmed.ncbi.nlm.nih.gov/30027839
https://pubmed.ncbi.nlm.nih.gov/30027839
Autor:
Alfonso Romero-Sandoval, Kristopher G. Virga, Carolina Moracho-Vilrriales, Perla Abigail Alvarado-Vazquez, Scott Asbill, Giuseppe Gumina, Alicia Bort
Publikováno v:
Molecular Pain
Background JWH015 is a cannabinoid (CB) receptor type 2 agonist that produces immunomodulatory effects. Since skin cells play a key role in inflammatory conditions and tissue repair, we investigated the ability of JWH015 to promote an anti-inflammato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49729c22cfa0970c086411a56259d0d
https://pubmed.ncbi.nlm.nih.gov/28326930
https://pubmed.ncbi.nlm.nih.gov/28326930
Synthetic Strategy toward γ-Keto Nitriles and Their Biocatalytic Conversion to Asymmetric γ-Lactones
Autor:
Brent D. Feske, Laura A. Wright, Richard Watkins, Ramon C. Hartage, Blair A. Weaver, Giuseppe Gumina, Sarah E. Franz, Ion Ghiviriga
Publikováno v:
Synthesis. 45:2171-2178
Asymmetric γ-hydroxy nitriles are valuable intermediates because hydrolysis of the nitriles can result in an intramolecular cyclization to chiral γ-lactones, which have a variety of biological uses. Starting with an assortment of different aldehyde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b89a8dad55c0740199de059977b3544
https://doi.org/10.1055/s-0033-1339282
https://doi.org/10.1055/s-0033-1339282
This review discusses next-generation antibacterial agents developed using rational, or targeted, drug design strategies. The focus of this review is on small-molecule compounds that have been designed to bypass developing bacterial resistance, impro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738bb24c680d999e4aeaa0368d5e7bc8
https://europepmc.org/articles/PMC5025264/
https://europepmc.org/articles/PMC5025264/
Autor:
Edoardo Virgilio, Giuseppe Gumina, Francesca Tozzi, Marco Cavallini, Yarilay Chacòn Marrero, Vincenzo Ziparo
Publikováno v:
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de7c73abe8b3abdb368540985673ebfa
http://hdl.handle.net/11573/948514
http://hdl.handle.net/11573/948514
Publikováno v:
Current Organic Chemistry. 11:1017-1032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e425a25a4a53d0d5d20b1477e5e79c5c
https://doi.org/10.2174/138527207781058754
https://doi.org/10.2174/138527207781058754
Autor:
Marco Vitali, Edoardo Virgilio, Giuseppe Gumina, Marco Cavallini, Paolo Mercantini, Michele Grieco
Publikováno v:
Surgical infections. 16(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9791f84fa3fbe9d4160b29e31e309dd
https://pubmed.ncbi.nlm.nih.gov/26110701
https://pubmed.ncbi.nlm.nih.gov/26110701