Výsledky vyhledávání - "Giuseppe Fraschini"

Phase II study of paclitaxel in patients with metastatic breast carcinoma refractory to standard chemotherapy

Autor: Kapil Dhingra, Edgardo Rivera, Aman U. Buzdar, Debra Frye, Giuseppe Fraschini, Daniel J. Booser, Gabriel N. Hortobagyi, Vicente Valero, Richard L. Theriault, Ronald S. Walters, Frankie A. Holmes

Publikováno v: Cancer. 89:2195-2201

BACKGROUND The authors conducted a single institution Phase II clinical trial to determine whether paclitaxel had antitumor activity in patients with metastatic breast carcinoma that was refractory to standard chemotherapy. METHODS Patients with meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d30ba197b6443efbf3022907c12038f1
https://doi.org/10.1002/1097-0142(20001201)89:11<2195::aid-cncr7>3.0.co

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Phase II study of mitoxantrone by 14-day continuous infusion with granulocyte colony-stimulating factor (GCSF) support in patients with metastatic breast cancer and limited prior therapy

Autor: Giuseppe Fraschini, Gabriel N. Hortobagyi, Lajos Pusztai, Frankie A. Holmes

Publikováno v: Cancer Chemotherapy and Pharmacology. 43:86-91

Purpose: Early phase II evaluation of intravenous bolus mitoxantrone indicated objective response rates of 17–36% in patients with metastatic breast cancer. Subsequently, it has been suggested that continuous infusion may be the optimal way to admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60bb28d841e0228709f9873b388ead32
https://doi.org/10.1007/s002800050867

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Chemotherapy-induced neutropenia and fever in patients with metastatic breast carcinoma receiving salvage chemotherapy

Autor: Z. Rahman, H. Y. Yap, Gabriel N. Hortobagyi, Laura Esparza-Guerra, Giuseppe Fraschini, Gerald P. Bodey

Publikováno v: Cancer. 79:1150-1157

BACKGROUND Chemotherapy-induced neutropenia and associated fever and infection are the most common complications of systemic chemotherapy. In this retrospective analysis, the authors evaluated the incidence of neutropenic fever, infection, and mortal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbe03d367c601824ca8f053978c77ca7
https://doi.org/10.1002/(sici)1097-0142(19970315)79:6<1150::aid-cncr13>3.0.co

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Sequence-dependent alteration of doxorubicin pharmacokinetics by paclitaxel in a phase I study of paclitaxel and doxorubicin in patients with metastatic breast cancer

Autor: Gabriel N. Hortobagyi, Robert A. Newman, Frankie A. Holmes, Vicente Valero, Richard L. Theriault, Timothy Madden, Jie Willey, Ronald S. Walters, Daniel J. Booser, Giuseppe Fraschini, Aman U. Buzdar

Publikováno v: Journal of Clinical Oncology. 14:2713-2721

PURPOSE To determine whether a schedule-dependent interaction occurs when paclitaxel and doxorubicin are administered sequentially. PATIENTS AND METHODS Ten patients with metastatic breast cancer received paclitaxel 125 mg/m2 over 24 hours either imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e070292cc9a48abdafc17d80eae4ee
https://doi.org/10.1200/jco.1996.14.10.2713

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Phase II trial of docetaxel: a new, highly effective antineoplastic agent in the management of patients with anthracycline-resistant metastatic breast cancer

Autor: Robert E. Bellet, Gabriel N. Hortobagyi, Richard L. Theriault, Giuseppe Fraschini, Aman U. Buzdar, Frankie A. Holmes, Laura Esparza, Vicente Valero, Ronald S. Walters, Gustavo Fonseca

Publikováno v: Journal of Clinical Oncology. 13:2886-2894

PURPOSE To determine the efficacy (objective response rate and duration of response and survival) and toxicity of docetaxel in patients with strictly defined anthracycline-resistant metastatic breast cancer (MBC). PATIENTS AND METHODS Thirty-five pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba9372e192e29daf8dabe390c8195b20
https://doi.org/10.1200/jco.1995.13.12.2886

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The Myeloprotective Effect of Recombinant Human Granulocyte-Macrophage Colony-stimulating Factor Given Sequentially with Continuous Infusion Vinblastine in Metastatic Breast Cancer Patients

Autor: Giuseppe Fraschini, Frankie A. Holmes, Gabriel N. Hortobagyi, Debbie Frye, Richard L. Theriault, Jordan U. Gutterman

Publikováno v: American Journal of Clinical Oncology. 16:132-136

Colony-stimulating factors have been shown to have a myeloprotective effect when administered following chemotherapy. Chemotherapy of short duration with predominantly cell-cycle nonspecific agents has been most used. The myeloprotective effects of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22eaef3653e7a69b023f3a4085292b87
https://doi.org/10.1097/00000421-199304000-00010

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Clinical course of patients with breast cancer with ten or more positive nodes who were treated with doxorubicin-containing adjuvant therapy

Autor: Aman U. Buzdar, Frankie A. Holmes, Giuseppe Fraschini, Marsha D. McNeese, Frederick C. Ames, S. Eva Singletary, Shu‐Wan ‐W Kau, Gabriel N. Hortobagyi, Richard L. Theriault, Verena Hug

Publikováno v: Cancer. 69:448-452

Between 1974 and 1986, 283 patients with ten or more positive nodes were treated in four prospective trials using doxorubicin-containing adjuvant chemotherapy. At a median follow-up of 92 months, 182 patients had had a recurrence, and 158 died. An es

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https://doi.org/10.1002/1097-0142(19920115)69:2<448::aid-cncr2820690229>3.0.co

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Is chemotherapy effective in reducing the local failure rate in patients with operable breast cancer?

Autor: Frankie A. Holmes, Marsha D. McNeese, Gabriel N. Hortobagyi, Nancy A. Ellerbroek, Terry L. Smith, Aman U. Buzdar, Giuseppe Fraschini, Verena Hug, S. Eva Singletary, Frederick C. Ames, Shu Kau

Publikováno v: Cancer. 65:394-399

To evaluate the role of chemotherapy in local control of primary breast cancer, the incidence of local failure was evaluated in 768 patients treated with surgery and adjuvant, combination chemotherapy that contained fluorouracil, doxorubicin, and cyc

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https://doi.org/10.1002/1097-0142(19900201)65:3<394::aid-cncr2820650303>3.0.co

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Elliptinium Acetate in Metastatic Breast Cancer – a Phase II Study

Autor: Gabriel N. Hortobagyi, Benjamin Lichtiger, Frankie A. Holmes, Jung S. Ro, Aman U. Buzdar, Laura Esparza, Giuseppe Fraschini

Publikováno v: Oncology. 47:101-104

Thirty-five patients with metastatic breast cancer who had received one or two prior chemotherapeutic regimens were treated with elliptinium acetate at a dose of 80 mg/m2 for 3 days every 3 weeks. Of the 33 patients evaluable for response, 1 patient

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https://doi.org/10.1159/000226797

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Inflammatory carcinoma of the breast: results of a combined-modality approach ? M. D. Anderson Cancer Center experience

Autor: Frederick C. Ames, Richard L. Theriault, Marsha D. McNeese, Verena Hug, Aman U. Buzdar, Gabriel N. Hortobagyi, Frankie A. Holmes, Giuseppe Fraschini, Debra Frye, S. Eva Singletary, Charles M. Balch, Eun H. Koh

Publikováno v: Cancer Chemotherapy and Pharmacology. 27:94-100

A total of 106 patients with inflammatory carcinoma of the breast underwent combined-modality treatment consisting of doxorubincin-containing chemotherapy. All patients received three cycles of 5-fluorouracil, doxorubicin, and cyclophosphamide (FAC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a680e0da65160c8d078589ddb1e219d3
https://doi.org/10.1007/bf00689090

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