Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Giuseppe Faraco"'
Autor:
Giuseppe Faraco, Maria Pittelli, Leonardo Cavone, Silvia Fossati, Marco Porcu, Paolo Mascagni, Gianluca Fossati, Flavio Moroni, Alberto Chiarugi
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 269-279 (2009)
Histone deacetylase inhibitors (HDACi) are emerging tools for epigenetic modulation of gene expression and suppress the inflammatory response in models of systemic immune activation. Yet, their effects within the brain are still controversial. Also,
Externí odkaz:
https://doaj.org/article/5f65e428ed664f81bcd672e70498f06b
Autor:
Askiel Bruno, Kai Hei Tse, Farzaneh A. Sorond, Jodi D. Edwards, Giuseppe Faraco, Anna Csiszar, Donna M. Wilcock, Zoltan Ungvari, Andy Y. Shih, Shawn N. Whitehead, S. Thomas Carmichael, Vladimir Hachinski, Deborah Gustafson, Gary A. Rosenberg, Frank C. Barone, Jeffrey M. Burns, Fanny M. Elahi, Douglas B. Gould, Kristen L. Zuloaga
Publikováno v:
GeroScience
Neuroscience Institute Publications
Neuroscience Institute Publications
White matter pathologies are critically involved in the etiology of vascular cognitive impairment-dementia (VCID), Alzheimer's disease (AD), and Alzheimer's disease and related diseases (ADRD), and therefore need to be considered a treatable target (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80bff1221571d8894b554264370a58f
https://doi.org/10.1007/s11357-021-00461-8
https://doi.org/10.1007/s11357-021-00461-8
Autor:
Monica M. Santisteban, Giuseppe Faraco, David Brea Lopez, Gang Wang, Melissa Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Josef Anrather, Costantino Iadecola
Hypertension, a disease afflicting over one billion individuals worldwide, is a leading cause of cognitive impairment, the mechanisms of which remain poorly understood. In a mouse model of hypertension involving brain angiotensin signaling, we found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6735aeb0438c39798bd5bef82d9cde4d
https://doi.org/10.1101/2022.09.05.506398
https://doi.org/10.1101/2022.09.05.506398
Autor:
Samantha M Schaeffer, Monica M Santisteban, Giuseppe Faraco, Lidia Garcia-bonilla, Josef Anrather, Costantino Iadecola
Publikováno v:
Hypertension. 79
Hypertension (HTN) disrupts vital neurovascular control mechanisms, thereby increasing the brain’s susceptibility to vascular insufficiency, white matter lesions, and cognitive impairment. Yet, the distinct vascular, neuronal, and glial cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17844a1b91b57ea6b0676241546b2f9
https://doi.org/10.1161/hyp.79.suppl_1.007
https://doi.org/10.1161/hyp.79.suppl_1.007
Autor:
Teresa Sanchez, Hira Niazi, Bertrand Tavitian, Hiroki Uchida, Aline Chevallier, Véronique Baudrie, Lidia Garcia-Bonilla, Christiane Charriaut-Marlangue, Anja Nitzsche, Costantino Iadecola, Marine Poittevin, Nathalie Kubis, Susan R. Schwab, Mari Kono, Daniel Henrion, Giuseppe Faraco, Richard L. Proia, Manuela Cl Garcia, Eric Camerer, Patrice Therond, Timothy Hla, Pierre-Louis Tharaux, Pierre-Louis Leger, Jerold Chun, Julie Favre, Philippe Bonnin, Thomas Mathivet, Ludovic Couty, Gwennhael Autret, Ammar Benarab, Anne Eichmann
Publikováno v:
Circ Res
Circulation Research
Circulation Research, 2021, 128 (3), pp.363-382. ⟨10.1161/CIRCRESAHA.120.316711⟩
Circulation Research
Circulation Research, 2021, 128 (3), pp.363-382. ⟨10.1161/CIRCRESAHA.120.316711⟩
Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular protective pathways may provide therapeutic targets for neurological disorders. S1P (Sphingosine 1-phosphate) signaling coordinates vascular functions in other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8446c110a74dfacb71d947b6264ee510
https://pubmed.ncbi.nlm.nih.gov/33539221
https://pubmed.ncbi.nlm.nih.gov/33539221
Autor:
Giuseppe Faraco, Sung Ji Ahn, Josef Anrather, Jakob Körbelin, Costantino Iadecola, Carrie Poon, Samantha Schaeffer, Gianfranco Racchumi, Steven G. Segarra, Lidia Garcia-Bonilla, Monica M Santisteban, Diane A. Lane
Publikováno v:
Hypertension
Hypertension is a leading cause of stroke and dementia, effects attributed to disrupting delivery of blood flow to the brain. Hypertension also alters the blood-brain barrier (BBB), a critical component of brain health. Although endothelial cells are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb6db287e67218292e0c57f0fdd0fea
https://pubmed.ncbi.nlm.nih.gov/32654560
https://pubmed.ncbi.nlm.nih.gov/32654560
Autor:
Lidia Garcia-Bonilla, Michelle Murphy, Giuseppe Faraco, Gang Wang, Kenzo Koizumi, Joseph Anrather, Henning U. Voss, David Brea, Monica M Santisteban, Haejoo Chang, Izaskun Buendia, Yukio Sugiyama, Steven G. Segarra, Gianfranco Racchumi, Costantino Iadecola
Publikováno v:
Nature Neuroscience. 21:240-249
A diet rich in salt is linked to an increased risk of cerebrovascular diseases and dementia, but it remains unclear how dietary salt harms the brain. We report that, in mice, excess dietary salt suppresses resting cerebral blood flow and endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9852778fa43b8bb70b67ce5abc71d7e
https://doi.org/10.1038/s41593-017-0059-z
https://doi.org/10.1038/s41593-017-0059-z
Publikováno v:
Journal of Molecular Medicine. 95:1143-1152
Perivascular macrophages (PVM) are a distinct population of resident brain macrophages characterized by a close association with the cerebral vasculature. PVM migrate from the yolk sac into the brain early in development and, like microglia, are like
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3acf4f8481f04e7fd2547c81c3823ef
https://doi.org/10.1007/s00109-017-1573-x
https://doi.org/10.1007/s00109-017-1573-x
Autor:
Sylvain Galvani, Josef Anrather, Keisuke Yanagida, Costantino Iadecola, Catherine H. Liu, Teresa Sanchez, Giuseppe Faraco, Timothy Hla, Nathalie Burg, Helen K. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4531-4536
The vasculature of the central nervous system (CNS) forms a selective barrier termed the blood-brain barrier (BBB). Disruption of the BBB may contribute to various CNS diseases. Conversely, the intact BBB restricts efficient penetration of CNS-target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a6c257e8573a539d665c326db5431
https://doi.org/10.1073/pnas.1618659114
https://doi.org/10.1073/pnas.1618659114
Autor:
Giuseppe Faraco, Josef Anrather, Monica M Santisteban, Costantino Iadecola, Lidia Garcia-Bonilla, Carrie Poon, Samantha Schaeffer, Diane A. Lane, Virginia Cipollini, Ziasmin Shahanoor, Gianfranco Racchumi, Steven G. Segarra, Sung Ji Ahn
Publikováno v:
Hypertension. 74
The blood-brain barrier (BBB) controls the molecular exchange between blood and brain and is critical for maintaining brain health. Although hypertension (HTN) is well known to disrupt the BBB, the underlying cellular bases and the susceptible cerebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be9eae11a8637337af8ec2c627e3814
https://doi.org/10.1161/hyp.74.suppl_1.050
https://doi.org/10.1161/hyp.74.suppl_1.050