Non-invasive in vivo imaging of changes in Collagen III turnover in myocardial fibrosis

Autor: Nadia Chaher, Sara Lacerda, Giuseppe Digilio, Sergio Padovan, Ling Gao, Begoña Lavin, Rachele Stefania, Carlos Velasco, Gastão Cruz, Claudia Prieto, René M. Botnar, Alkystis Phinikaridou

Publikováno v: npj Imaging, Vol 2, Iss 1, Pp 1-15 (2024)

Abstract Heart failure (HF) affects 64 million people globally with enormous societal and healthcare costs. Myocardial fibrosis, characterised by changes in collagen content drives HF. Despite evidence that collagen type III (COL3) content changes du

Externí odkaz: https://doaj.org/article/ff8b727e1ffe447b80b59714d8367065

Microwave Heating Promotes the S-Alkylation of Aziridine Catalyzed by Molecular Sieves: A Post-Synthetic Approach to Lanthionine-Containing Peptides

Autor: Valentina Verdoliva, Giuseppe Digilio, Michele Saviano, Stefania De Luca

Publikováno v: Molecules, Vol 26, Iss 20, p 6135 (2021)

Aziridine derivatives involved in nucleophilic ring-opening reactions have attracted great interest, since they allow the preparation of biologically active molecules. A chemoselective and mild procedure to convert a peptide cysteine residue into lan

Externí odkaz: https://doaj.org/article/d832b67d15a44d418f580518ce6dbfef

Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides

Autor: Valeria Lagostina, Loredana Leone, Fabio Carniato, Giuseppe Digilio, Lorenzo Tei, Mauro Botta

Publikováno v: Inorganics, Vol 7, Iss 4, p 43 (2019)

Three different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III

Externí odkaz: https://doaj.org/article/5aaf56a715084b05ad47ef6ebc15beee

Glycol Chitosan Functionalized with a Gd(III) Chelate as a Redox‐responsive Magnetic Resonance Imaging Probe to Label Cell Embedding Alginate Capsules

Autor: Giuseppe Digilio, Valeria Catanzaro, Malvina Koni, Sergio Padovan, Cristina Grange, Carla Carrera

Publikováno v: Chemistry – A European Journal. 27:12289-12293

One possibility for the non-invasive imaging of encapsulated cell grafts is to label the lumen of cell embedding capsules with a redox-responsive probe, as an increased extracellular reducing potential can be considered as a marker of hypoxia-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4047c39d32da0b48989464e642b58ec8
https://doi.org/10.1002/chem.202101657

Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

Autor: Alkystis Phinikaridou, Giuseppe Digilio, Federico Capuana, Silvio Aime, René M. Botnar, Sergio Padovan, Eyad Almouazen, Begoña Lavin, Laurence Heinrich-Balard, Sara Lacerda, Yves Chevalier, Rachele Stefania

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (20), pp.15250-15261. ⟨10.1021/acs.jmedchem.1c01286⟩
Journal of Medicinal Chemistry, 2021, 64 (20), pp.15250-15261. ⟨10.1021/acs.jmedchem.1c01286⟩

International audience; Dysfunctional elastin turnover plays a major role in the progression of atherosclerotic plaques. Failure of tropoelastin cross-linking into mature elastin leads to the accumulation of tropoelastin within the growing plaque, in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ff663686f8c067cdd6f07d0f557d0d
https://hal.archives-ouvertes.fr/hal-03409627