N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection

Autor: S. Sadia Ameen, Nane Griem-Krey, Antoine Dufour, M. Iqbal Hossain, Ashfaqul Hoque, Sharelle Sturgeon, Harshal Nandurkar, Dominik F. Draxler, Robert L. Medcalf, Mohd Aizuddin Kamaruddin, Isabelle S. Lucet, Michael G. Leeming, Dazhi Liu, Amardeep Dhillon, Jet Phey Lim, Faiza Basheer, Hong-Jian Zhu, Laita Bokhari, Carli L. Roulston, Prasad N. Paradkar, Oded Kleifeld, Andrew N. Clarkson, Petrine Wellendorph, Giuseppe D. Ciccotosto, Nicholas A. Williamson, Ching-Seng Ang, Heung-Chin Cheng

Publikováno v: Ameen, S S, Griem-Krey, N, Dufour, A, Hossain, M I, Hoque, A, Sturgeon, S, Nandurkar, H, Draxler, D F, Medcalf, R L, Kamaruddin, M A, Lucet, I S, Leeming, M G, Liu, D, Dhillon, A, Lim, J P, Basheer, F, Zhu, H J, Bokhari, L, Roulston, C L, Paradkar, P N, Kleifeld, O, Clarkson, A N, Wellendorph, P, Ciccotosto, G D, Williamson, N A, Ang, C S & Cheng, H C 2023, ' N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection ', Molecular & cellular proteomics : MCP, vol. 22, no. 5, 100543 . https://doi.org/10.1016/j.mcpro.2023.100543
Molecular & cellular proteomics : MCP, vol 22, iss 5

Excitotoxicity, a neuronal death process in neurological disorders such as stroke, is initiated by the overstimulation of ionotropic glutamate receptors. Although dysregulation of proteolytic signaling networks is critical for excitotoxicity, the ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a980e6e528169653b1b0ed50175569
https://curis.ku.dk/ws/files/357280187/1_s2.0_S1535947623000531_main.pdf

The Alzheimer’s Disease Amyloid Precursor Protein and its Neuritogenic Actions

Autor: Luan Luu, Giuseppe D. Ciccotosto, Roberto Cappai

Publikováno v: Current Alzheimer Research. 18:772-786

The Amyloid Precursor Protein (APP) is principally known and studied for its involvement in Alzheimer’s disease as the source of the amyloid β peptide; however, its physiological actions within the nervous system are also important as it is involv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16dd24d9a9fc9142a9e97078f572bc91
https://doi.org/10.2174/1567205018666211208141017

Simultaneous inhibition of CTGF and Autotaxin reduces lung fibrosis and improves lung function in mice

Autor: Robert J.J. O'Donoghue, Gary P. Anderson, Caitlin O'Brien, Giuseppe D. Ciccotosto, Delaney Haugan, Mun Joo Chuei, Thomas Jaquin, Ellie H-J Cho, Goran Martic, Vanessa Welk, Andrew G. Jarnicki, Gabrielle Matschiner, Kathryn Stok

Publikováno v: Mechanisms of lung injury and repair.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30108812ebca0279fe602394045b8674
https://doi.org/10.1183/13993003.congress-2021.pa733

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Autor: Roberto Cappai, Margaret Ayers, Loredana Spoerri, Giuseppe D. Ciccotosto, Tobias D. Merson, Mun Joo Chuei, Ben Emery, Yao Lulu Xing, Phan H. Truong

Publikováno v: Glia. 67:525-538

The identification of factors that regulate myelination provides important insight into the molecular mechanisms that coordinate nervous system development and myelin regeneration after injury. In this study, we investigated the role of amyloid precu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699730c357874c70c501c8b39cdbdf61
https://doi.org/10.1002/glia.23561

Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein.

Autor: Jiang-Li Tan, Qiao-Xin Li, Giuseppe D Ciccotosto, Peter John Crouch, Janetta Gladys Culvenor, Anthony Robert White, Genevieve Evin

Publikováno v: PLoS ONE, Vol 8, Iss 4, p e61246 (2013)

BACE1 is responsible for β-secretase cleavage of the amyloid precursor protein (APP), which represents the first step in the production of amyloid β (Aβ) peptides. Previous reports, by us and others, have indicated that the levels of BACE1 protein

Externí odkaz: https://doaj.org/article/2b897aca4f9544349be226e3a8651143