Výsledky vyhledávání - "Giuseppe Cetta"

Human prolidase and prolidase deficiency: an overview on the characterization of the enzyme involved in proline recycling and on the effects of its mutations

Autor: Giuseppe Cetta, Anna Lupi, Antonio Rossi, Antonella Forlino, Ruggero Tenni

Publikováno v: Amino Acids. 35:739-752

Here we summarized what is known at the present about function, structure and effect of mutations in the human prolidase. Among the peptidases, prolidase is the only metalloenzyme that cleaves the iminodipeptides containing a proline or hydroxyprolin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8606fab6d61e46c88e7b5e81703ca04
https://doi.org/10.1007/s00726-008-0055-4

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Differential expression of both extracellular and intracellular proteins is involved in the lethal or nonlethal phenotypic variation of BrtlIV, a murine model for osteogenesis imperfecta

Autor: Chiara Tani, Antonio Rossi, Anna Lupi, Luca Bini, Benedetta Gualeni, Antonella Forlino, Giuseppe Cetta, Elena Campari, Alessandro Armini, Laura Bianchi, Joan C. Marini

Publikováno v: PROTEOMICS. 7:1877-1891

This study used proteomic and transcriptomic techniques to understand the molecular basis of the phenotypic variability in the bone disorder osteogenesis imperfecta (OI). Calvarial bone mRNA expression was evaluated by microarray, real-time, and comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493d9a5b0461eff204d8765e8718aede
https://doi.org/10.1002/pmic.200600919

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The role of emerging techniques in the investigation of prolidase deficiency: From diagnosis to the development of a possible therapeutical approach

Autor: Giuseppe Cetta, Bice Conti, Simona Viglio, Ida Genta, Begona Casado, Laura Annovazzi, Paola Perugini, Chiara Zanone, Paolo Iadarola

Publikováno v: Journal of Chromatography B. 832:1-8

The aim of the present article is to review the efforts performed in the past two decades by numerous research groups for the development of methods that allow a correct diagnosis of prolidase deficiency (PD), a rare autosomal recessive disorder and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd9ff2dccf047905f6ba46fb0e15afd
https://doi.org/10.1016/j.jchromb.2005.12.049

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N-benzyloxycarbonyl-l-proline: An in vitro and in vivo inhibitor of prolidase

Autor: Anna Lupi, Angelo Gallanti, Patrizia Vaghi, Giuseppe Cetta, Antonio Rossi, Antonella Forlino

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1744(2):157-163

Prolidase deficiency (PD) is a recessive disorder of the connective tissue caused by mutations in the prolidase, a specific peptidase, cleaving the dipeptides with a C-terminal prolyl and hydroxyprolyl residue. PD is a complex syndrome characterized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06efc8251856e3ea6909bf257ca6278e

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2-Microglobulin isoforms display an heterogeneous affinity for type I collagen

Autor: Vittorio Bellotti, Palma Mangione, Antonio Rossi, Giuseppe Cetta, Alessandra Corazza, Monica Stoppini, Giampaolo Merlini, Gennaro Esposito, Sara Raimondi, Paolo Viglino, Sara Marini, Sofia Giorgetti

Publikováno v: Protein Science. 14:696-702

It has been claimed that beta2-microglobulin (beta2-m) interacts with type I and type II collagen, and this property has been linked to the tissue specificity of the beta2-m amyloid deposits that target the osteo-articular system. The binding paramet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ce4707c5ad1d3d0b527436bf744517
https://doi.org/10.1110/ps.041194005

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Micellar electrokinetic chromatographic and capillary zone electrophoretic methods for screening urinary biomarkers of human disorders: A critical review of the state‐of‐the‐art

Autor: Paolo Iadarola, Giuseppe Cetta, James N. Baraniuk, Laura Annovazzi, Begona Casado, Chiara Zanone, Maurizio Luisetti, Simona Viglio

Publikováno v: ELECTROPHORESIS. 26:752-766

Human urine plays a central role in clinical diagnostic being one of the most-frequently used body fluid for detection of biological markers. Samples from patients with different diseases display patterns of biomarkers that differ significantly from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0d9a65dd92d1ce4baa33c5fea95cfc
https://doi.org/10.1002/elps.200410195

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High-performance liquid chromatography and capillary electrophoresis: Methodological challenges for the determination of biologically relevant low-aliphatic aldehydes in human saliva

Autor: Fabio Pecora, Giuseppe Cetta, Paolo Iadarola, Vitaliano Cattaneo, Laura Annovazzi, C. Rota, Chiara Zanone, Simona Viglio, Eleonora Perani, Maurizio Silvestri

Publikováno v: ELECTROPHORESIS. 25:1255-1263

Tobacco smoke is involved in the pathogenesis of cardiovascular and respiratory diseases and also has a local toxic effect in the oral cavity. Low-aliphatic aldehydes, such as formaldehyde, acetaldehyde and acrolein, are among the main components of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae430bab87fefb132a426bd5be802e
https://doi.org/10.1002/elps.200305843

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Biodegradable microspheres for prolidase delivery to human cultured fibroblasts

Autor: Paola Perugini, Franca Pavanetto, Begona Casado, Paolo Iadarola, Anna Lupi, Ida Genta, Giuseppe Cetta, Tiziana Modena, Bice Conti

Publikováno v: Journal of Pharmacy and Pharmacology. 56:597-603

Prolidase deficiency (PD) is a rare autosomal recessive disorder caused by inadequate levels of the cytosolic exopeptidase prolidase (E.C. 3.4.13.9), for which there is not, as yet, a resolutive cure. We have investigated whether biodegradable micros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77adbdf996475971a7aa355db810466
https://doi.org/10.1211/0022357023349

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Capillary electrophoresis with laser-induced fluorescence detection as a novel sensitive approach for the analysis of desmosines in real samples

Autor: Simona Viglio, Laura Annovazzi, James N. Baraniuk, Maurizio Luisetti, Paolo Iadarola, Eleonora Perani, Begona Casado, Giuseppe Cetta

Publikováno v: ELECTROPHORESIS. 25:683-691

Among various biomarkers believed to behave as descriptors of the disease process in chronic obstructive pulmonary disease (COPD), urinary desmosines are commonly used for monitoring elastin degradation. Given the low concentrations of urinary desmos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c20cc3779653294f4501d692ce5653
https://doi.org/10.1002/elps.200305607

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Effect of enamel matrix derivative on human periodontal fibroblasts: proliferation, morphology and root surface colonization. An in vitro study

Autor: Angelo Gallanti, Cesare Piacentini, C. Rota, Giulio Rasperini, Maurizio Silvestri, Antonella Forlino, Giuseppe Cetta, Vitaliano Cattaneo

Publikováno v: Journal of Periodontal Research. 38:568-574

Background: Several clinical trials have shown the effectiveness of Emdogain® (EMD) in promoting tissue regeneration, even though the underlining biological mechanism is still poorly known. Objectives: The aim of the present study was to verify the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52f09ee172d7419343ba8c114c92881d
https://doi.org/10.1034/j.1600-0765.2003.00690.x

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