Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway

Autor: Nitish Sathyanarayanan, Giuseppe Cannone, Lokesh Gakhar, Nainesh Katagihallimath, Ramanathan Sowdhamini, Subramanian Ramaswamy, Kutti R. Vinothkumar

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

The bacterial enzyme PaaZ is involved in the breakdown of environmental pollutants via the aerobic-anaerobic hybrid pathway but its substrate transfer mechanism is not fully understood. Here, the authors present cryoEM structures of free and ligand-b

Externí odkaz: https://doaj.org/article/6a6fe31ff0ab4ec58d220d185727fa01

A conserved mechanism for regulating replisome disassembly in eukaryotes

Autor: Tom D Deegan, Karim Labib, Giuseppe Cannone, Michael Jenkyn-Bedford, Joseph T.P. Yeeles, Yasemin Baris, Morgan L. Jones

Publikováno v: Nature
Jenkyn-Bedford, M, Jones, M L, Baris, Y, Labib, K P M, Cannone, G, Yeeles, J T P & Deegan, T D 2021, ' A Conserved Mechanism for Regulating Replisome Disassembly in Eukaryotes ', Nature . https://doi.org/10.1038/s41586-021-04145-3

Replisome disassembly is the final step of eukaryotic DNA replication and is triggered by ubiquitylation of the CDC45–MCM–GINS (CMG) replicative helicase1–3. Despite being driven by evolutionarily diverse E3 ubiquitin ligases in different eukar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3762dde9c47e717fe2f32dd809798c47
https://doi.org/10.1038/s41586-021-04145-3

Smart data collection for CryoEM

Autor: Tristan Bepler, Andrew J. Borst, Jonathan Bouvette, Giuseppe Cannone, Songye Chen, Anchi Cheng, Ao Cheng, Quanfu Fan, Fanis Grollios, Harshit Gupta, Meghna Gupta, Theo Humphreys, Paul T. Kim, Huihui Kuang, Yilai Li, Alex J. Noble, Ali Punjani, William J. Rice, Carlos Oscar S. Sorzano, Scott M. Stagg, Joshua Strauss, Lingbo Yu, Bridget Carragher, Clinton S. Potter

Publikováno v: Journal of structural biology. 214(4)

This report provides an overview of the discussions, presentations, and consensus thinking from the Workshop on Smart Data Collection for CryoEM held at the New York Structural Biology Center on April 6-7, 2022. The goal of the workshop was to addres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2fcb84003f84ad7b748d599572c7a
https://pubmed.ncbi.nlm.nih.gov/36341954

[Recent advances in the structural biology of the class C G protein-coupled receptors: The metabotropic Glutamate receptor 5]

Autor: Ludovic, Berto, Anaëlle, Dumazer, Fanny, Malhaire, Giuseppe, Cannone, Vinothkumar, Kutti Ragunath, Cyril, Goudet, Guillaume, Lebon

Publikováno v: Biologie aujourd'hui. 215(3-4)

Class C GPCRs, that include metabotropic glutamate receptors (mGlu), taste receptors, GABALes avancées récentes dans le domaine de la biologie structurale des récepteurs couplés aux protéines G de la classe C : Le récepteur métabotropique du g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2e59efa70d668670cf5d40f7a444f7e
https://pubmed.ncbi.nlm.nih.gov/35275053

A multipronged approach to understanding the form and function of hStaufen protein

Autor: Brian O. Smith, Luke A. Clifton, Giuseppe Cannone, Michael L. Gleghorn, Gemma Harris, James Doutch, Laura Spagnolo, Silvia Visentin

Publikováno v: Visentin, S, Cannone, G, Doutch, J, Harris, G, Gleghorn, M L, Clifton, L, Smith, B O & Spagnolo, L 2020, ' A multipronged approach to understanding the form and function of hStaufen protein ', RNA, vol. 26, no. 3, pp. 265-277 . https://doi.org/10.1261/rna.072595.119
RNA

Staufen is a dsRNA-binding protein involved in many aspects of RNA regulation, such as mRNA transport, Staufen-mediated mRNA decay and the regulation of mRNA translation. It is a modular protein characterized by the presence of conserved consensus am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96648a2b95fa7a9e5e82ddb5b593c0f0
https://www.pure.ed.ac.uk/ws/files/142842235/RNA_2020_Visentin_265_77.pdf