Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Giuseppe Cannino"'
Autor:
Claudio Laquatra, Carlos Sanchez-Martin, Alberto Dinarello, Giuseppe Cannino, Giovanni Minervini, Elisabetta Moroni, Marco Schiavone, Silvio Tosatto, Francesco Argenton, Giorgio Colombo, Paolo Bernardi, Ionica Masgras, Andrea Rasola
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Abstract The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expr
Externí odkaz:
https://doaj.org/article/8e6dec8899704ed197fe94fdfa0442d0
Autor:
Tiina S. Salminen, Giuseppe Cannino, Marcos T. Oliveira, Päivi Lillsunde, Howard T. Jacobs, Laurie S. Kaguni
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 7, Pp 2225-2234 (2019)
Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). Here we tested whether any of four natural mtDNA variants was able to modify the effect of the phenotypically mi
Externí odkaz:
https://doaj.org/article/ee17888e1aa0495288cf572b578edc6f
Autor:
Carlos Sanchez-Martin, Elisabetta Moroni, Mariarosaria Ferraro, Claudio Laquatra, Giuseppe Cannino, Ionica Masgras, Alessandro Negro, Paolo Quadrelli, Andrea Rasola, Giorgio Colombo
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: TRAP1 is the mitochondrial paralog of the heat shock protein 90 (HSP90) chaperone family. Its activity as an energy metabolism regulator has important implications in cancer, neurodegeneration, and ischemia. Selective inhibitors of TRAP1 cou
Externí odkaz:
https://doaj.org/article/9fd14b74e0544bfaac1ed8890e0c77df
Autor:
Ionica Masgras, Francesco Ciscato, Anna Maria Brunati, Elena Tibaldi, Stefano Indraccolo, Matteo Curtarello, Federica Chiara, Giuseppe Cannino, Elena Papaleo, Matteo Lambrughi, Giulia Guzzo, Alberto Gambalunga, Marco Pizzi, Vincenza Guzzardo, Massimo Rugge, Stefania Edith Vuljan, Fiorella Calabrese, Paolo Bernardi, Andrea Rasola
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 659-672 (2017)
Mutations in neurofibromin, a Ras GTPase-activating protein, lead to the tumor predisposition syndrome neurofibromatosis type 1. Here, we report that cells lacking neurofibromin exhibit enhanced glycolysis and decreased respiration in a Ras/ERK-depen
Externí odkaz:
https://doaj.org/article/5ef12b229fed44ec8de2df96396d1352
Autor:
Giulia Ambrosini, Elisa Dalla Pozza, Giuseppina Fanelli, Claudia Di Carlo, Andrea Vettori, Giuseppe Cannino, Chiara Cavallini, Cristian Andres Carmona-Carmona, Jessica Brandi, Sara Rinalducci, Maria Teresa Scupoli, Andrea Rasola, Daniela Cecconi, Marta Palmieri, Ilaria Dando
Publikováno v:
Cells, Vol 9, Iss 7, p 1572 (2020)
Pancreatic ductal adenocarcinoma (PDAC) is typically characterized by high chemoresistance and metastatic spread, features mainly attributable to cancer stem cells (CSCs). It is of central interest the characterization of CSCs and, in particular, the
Externí odkaz:
https://doaj.org/article/8bab7396a5464083a22fd14d1897c6cb
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must p
Externí odkaz:
https://doaj.org/article/2eff3305b7ee4a4eb276c553b512a3a4
Autor:
Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour, Howard T Jacobs
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 6, Pp 1-21 (2014)
Abstract The machinery of mitochondrial DNA (mtDNA) maintenance is only partially characterized and is of wide interest due to its involvement in disease. To identify novel components of this machinery, plus other cellular pathways required for mtDNA
Externí odkaz:
https://doaj.org/article/629230bae33c496f87c349e65211add4
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141036 (2015)
Externí odkaz:
https://doaj.org/article/a8381dc93a554a3b88c1fb15e6478c31
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131990 (2015)
INTRODUCTION:Diabetes Associated Protein in Insulin-sensitive Tissues (DAPIT) is a subunit of mitochondrial ATP synthase and has also been found to associate with the vacuolar H+-ATPase. Its expression is particularly high in cells with elevated aero
Externí odkaz:
https://doaj.org/article/a59d7b377eeb46cdbacb707c9a9db681
Autor:
Ionica Masgras, Giuseppe Cannino, Francesco Ciscato, Carlos Sanchez-Martin, Fereshteh Babaei Darvishi, Francesca Scantamburlo, Marco Pizzi, Alessio Menga, Dolores Fregona, Alessandra Castegna, Andrea Rasola
Publikováno v:
Cell Death & Differentiation. 29:1996-2008
Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in an ERK-dependent fashion, de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d4298155fd8b5a531d1b2989b2a2df
https://doi.org/10.1038/s41418-022-00991-4
https://doi.org/10.1038/s41418-022-00991-4