Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Giuseppe Campiani"'
Autor:
Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T. Baldari, Giuseppe Campiani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116537- (2024)
Chronic Lymphocytic Leukemia (CLL) patients have a defective expression of the proapoptotic protein p66Shc and of its transcriptional factor STAT4, which evoke molecular abnormalities, impairing apoptosis and worsening disease prognosis and severity.
Externí odkaz:
https://doaj.org/article/5b5fa73fa7a44b40b6f5ece58f9ee513
Autor:
Luca Frattaruolo, Graziantonio Lauria, Francesca Aiello, Gabriele Carullo, Rosita Curcio, Marco Fiorillo, Giuseppe Campiani, Vincenza Dolce, Anna Rita Cappello
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7907 (2024)
Research on the energy metabolism of cancer cells is becoming a central element in oncology, and in recent decades, it has allowed us to better understand the mechanisms underlying the onset and chemoresistance of oncological pathologies. Mitochondri
Externí odkaz:
https://doaj.org/article/f27b2a3b425245bb8ba340310ed70a3f
Autor:
Roberto Gimmelli, Giuliana Papoff, Fulvio Saccoccia, Cristiana Lalli, Sandra Gemma, Giuseppe Campiani, Giovina Ruberti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011992 (2024)
Schistosomiasis is a major neglected parasitic disease that affects more than 240 million people worldwide caused by Platyhelminthes of the genus Schistosoma. The treatment of schistosomiasis relies on the long-term application of a single safe drug,
Externí odkaz:
https://doaj.org/article/0dfe90516e1e4bc0866785472651d7ce
Autor:
Gabriele Carullo, Giovanni Di Bonaventura, Sara Rossi, Veronica Lupetti, Valeria Tudino, Simone Brogi, Stefania Butini, Giuseppe Campiani, Sandra Gemma, Arianna Pompilio
Publikováno v:
Molecules, Vol 28, Iss 18, p 6535 (2023)
Pseudomonas aeruginosa (PA), one of the ESKAPE pathogens, is an opportunistic Gram-negative bacterium responsible for nosocomial infections in humans but also for infections in patients affected by AIDS, cancer, or cystic fibrosis (CF). Treatment of
Externí odkaz:
https://doaj.org/article/b4cd53bf6d794b5bae78256ba7016889
Autor:
Magda Ghanim, Nicola Relitti, Gavin McManus, Stefania Butini, Andrea Cappelli, Giuseppe Campiani, K. H. Mok, Vincent P. Kelly
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract CD44 is emerging as an important receptor biomarker for various cancers. Amongst these is oral cancer, where surgical resection remains an essential mode of treatment. Unfortunately, surgery is frequently associated with permanent disfigurem
Externí odkaz:
https://doaj.org/article/9ef5f59b2e7b4659947e0657bc72efe2
Autor:
Ludovica Marotta, Sara Rossi, Roberta Ibba, Simone Brogi, Vincenzo Calderone, Stefania Butini, Giuseppe Campiani, Sandra Gemma
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The sustainable use of resources is essential in all production areas, including pharmaceuticals. However, the aspect of sustainability needs to be taken into consideration not only in the production phase, but during the whole medicinal chemistry dr
Externí odkaz:
https://doaj.org/article/28ceae3b04d149aa93a72b58002f87b1
Autor:
Anna Fontana, Ilaria Cursaro, Gabriele Carullo, Sandra Gemma, Stefania Butini, Giuseppe Campiani
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 10014 (2022)
Histone deacetylases (HDACs) are epigenetic enzymes which participate in transcriptional repression and chromatin condensation mechanisms by removing the acetyl moiety from acetylated ε-amino group of histone lysines and other non-histone proteins.
Externí odkaz:
https://doaj.org/article/f5b6f32a35a74aa997a5942e4d94c1ab
Autor:
Gabriele Carullo, Simona Saponara, Amer Ahmed, Beatrice Gorelli, Sarah Mazzotta, Alfonso Trezza, Beatrice Gianibbi, Giuseppe Campiani, Fabio Fusi, Francesca Aiello
Publikováno v:
Marine Drugs, Vol 20, Iss 8, p 515 (2022)
Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareo
Externí odkaz:
https://doaj.org/article/6344eb9bf13548c9bf987bc885a2082f
Autor:
Simone Brogi, Sara Rossi, Roberta Ibba, Stefania Butini, Vincenzo Calderone, Giuseppe Campiani, Sandra Gemma
Publikováno v:
Computation, Vol 10, Iss 5, p 69 (2022)
Despite the progress of therapeutic approaches for treating COVID-19 infection, the interest in developing effective antiviral agents is still high, due to the possibility of the insurgence of viable SARS-CoV-2-resistant strains. Accordingly, in this
Externí odkaz:
https://doaj.org/article/98dd4e8cc65645d3a988ef1cfb6de918
Autor:
Simone Brogi, Roberta Ibba, Sara Rossi, Stefania Butini, Vincenzo Calderone, Sandra Gemma, Giuseppe Campiani
Publikováno v:
Molecules, Vol 27, Iss 8, p 2561 (2022)
In the field of drug discovery, the nitrile group is well represented among drugs and biologically active compounds. It can form both non-covalent and covalent interactions with diverse biological targets, and it is amenable as an electrophilic warhe
Externí odkaz:
https://doaj.org/article/d8cf81a8f50249849730be6dcae563b2