Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Giuseppe Allegretta"'
Autor:
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Rolf W. Hartmann, Laurence Rahme, Martin Empting
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensin
Externí odkaz:
https://doaj.org/article/9c7fffecdf724a0497e57d75b984355f
Autor:
Emanuele M Gargano, Giuseppe Allegretta, Enrico Perspicace, Angelo Carotti, Chris Van Koppen, Martin Frotscher, Sandrine Marchais-Oberwinkler, Rolf W Hartmann
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134754 (2015)
Design and synthesis of a new class of inhibitors for the treatment of osteoporosis and its comparative h17β-HSD2 and m17β-HSD2 SAR study are described. 17a is the first compound to show strong inhibition of both h17β-HSD2 and m17β-HSD2, intracel
Externí odkaz:
https://doaj.org/article/0bc4d2b54c854517a63ff00bf9fcb5c9
Autor:
Neeta Soni, Eric P. Westra, Giuseppe Allegretta, André L. S. Araujo, Camila F. de Pinho, Sarah Morran, Jens Lerchl, Franck E. Dayan, Philip Westra, Todd A. Gaines
Publikováno v:
Pest Management Science. 78:5080-5089
Early detection of herbicide resistance in weeds is crucial for successful implementation of integrated weed management. We conducted a herbicide resistance survey of the winter annual grasses feral rye (Secale cereale), downy brome (Bromus tectorum)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5641f00c8b24f7b98e7a9f029c730d
https://doi.org/10.1002/ps.7154
https://doi.org/10.1002/ps.7154
Autor:
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Rolf W. Hartmann, Laurence Rahme, Martin Empting
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required. Interfering with Quorum Sensin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::889c055998baaafeddfda59200ee919a
Autor:
Kiran V. Mahasenan, Jeshina Janardhanan, Sara Tejera, Elena Lastochkin, Shahriar Mobashery, Yuanyuan Qian, William R. Wolter, Giuseppe Allegretta, Zhihong Peng, Melissa Malia N. Gozun, Mayland Chang, Rhona Feltzer, Valerie A. Schroeder
Publikováno v:
Journal of Medicinal Chemistry. 63:5287-5296
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure-activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6291ab9052c87a4a8a8d6f64b0fe64be
https://doi.org/10.1021/acs.jmedchem.0c00153
https://doi.org/10.1021/acs.jmedchem.0c00153
Autor:
Yuanyuan, Qian, Giuseppe, Allegretta, Jeshina, Janardhanan, Zhihong, Peng, Kiran V, Mahasenan, Elena, Lastochkin, Melissa Malia N, Gozun, Sara, Tejera, Valerie A, Schroeder, William R, Wolter, Rhona, Feltzer, Shahriar, Mobashery, Mayland, Chang
Publikováno v:
J Med Chem
We report herein the syntheses of 79 derivatives of the 4(3H)-quinazolinones and their structure–activity relationship (SAR) against methicillin-resistant Staphylococcus aureus (MRSA). Twenty one analogs were further evaluated in in vitro assays. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::152bc927bf3a7db1e25ac82eece1fd30
https://pubmed.ncbi.nlm.nih.gov/32343145
https://pubmed.ncbi.nlm.nih.gov/32343145
Autor:
Xabier Murgia, Verena Fetz, Felix Beckmann, Sarah Gordon, Giuseppe Allegretta, Chiara De Rossi, Florian Graef, Walid A. M. Elgaher, Martin Empting, Nicole Schneider-Daum, Robert Richter, Claus-Michael Lehr, Mark Brönstrup, Rolf W. Hartmann, Jörg Haupenthal
Publikováno v:
ACS infectious diseases. 4(8)
The cell envelope of Gram-negative bacteria is a formidable biological barrier, inhibiting the action of antibiotics by impeding their permeation into the intracellular environment. In-depth understanding of permeation through this barrier remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9b90c931dd1ca79fbbe594e2f9667ab
https://pubmed.ncbi.nlm.nih.gov/29750862
https://pubmed.ncbi.nlm.nih.gov/29750862
Autor:
Rolf W. Hartmann, Isabell Schnorr, Scott G. Franzblau, Ahmed A. M. Kamal, Giuseppe Allegretta, Alexander Schifrin, Joerg Haupenthal, Andreas Thomann, Martin Empting, Sang-Hyun Cho, Jens Eberhard, Christian Brengel
Publikováno v:
ChemMedChem
The development of novel antimycobacterial agents against Mycobacterium tuberculosis (Mtb) is urgently required due to the appearance of multidrug resistance (MDR) combined with complicated long-term treatment. CYP121 was shown to be a promising nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3106114dc6d9dde0e9bf67b0171ef0
https://hdl.handle.net/10033/621515
https://hdl.handle.net/10033/621515
Autor:
Gerhard Unteregger, Michael J. Hoffmann, Giuseppe Allegretta, Carsten-H. Ohlmann, Michael Stöckle, Rolf W. Hartmann, Jill A. van der Zee, Kerstin Junker, Jörg Haupenthal, Antonio G. Gomes de Mello Martins, Jens Eberhard, Rolf Müller
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 174
CYP17A1-independent intratumoral steroid hormone synthesis is regarded as one possible explanation for resistance to treatment with the CYP17-inhibitor Abiraterone (Abi). The aim of our study was therefore to investigate the steroid metabolism of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34112893c98a99a3c7ac1f5c7c2f6e6
https://pubmed.ncbi.nlm.nih.gov/28890368
https://pubmed.ncbi.nlm.nih.gov/28890368
Autor:
Ahmed A. M. Kamal, Christine K. Maurer, Martin Empting, Giuseppe Allegretta, Rolf W. Hartmann, Jörg Haupenthal
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783319708386
Decades after the Golden Age of antibiotics, it is evident that antibiotic resistance is rapidly evolving and spreading among clinically relevant pathogens. The medical need for alternative anti-infective treatments is tremendously high today. A nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fdd34f2a611cb3ed7170a4b5f4c1720
https://doi.org/10.1007/7355_2017_17
https://doi.org/10.1007/7355_2017_17