Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Giuseppe, Testa"'
Autor:
Claudio Peter D’Incal, Elisa Cappuyns, Kaoutar Choukri, Kevin De Man, Kristy Szrama, Anthony Konings, Lina Bastini, Kim Van Meel, Amber Buys, Michele Gabriele, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Fabio Mohn, Marc Bühler, Nathalie Van der Aa, Anke Van Dijck, R. Frank Kooy, Wim Vanden Berghe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract Heterozygous de novo mutations in the Activity-Dependent Neuroprotective Homeobox (ADNP) gene underlie Helsmoortel-Van der Aa syndrome (HVDAS). Most of these mutations are situated in the last exon and we previously demonstrated escape from
Externí odkaz:
https://doaj.org/article/f7c381ec5b634584bcd2d05f0e32ea1f
Autor:
Chiara Battistini, Hilary A. Kenny, Melissa Zambuto, Valentina Nieddu, Valentina Melocchi, Alessandra Decio, Pietro Lo Riso, Carlo Emanuele Villa, Alessia Gatto, Mariacristina Ghioni, Francesca M. Porta, Giuseppe Testa, Raffaella Giavazzi, Nicoletta Colombo, Fabrizio Bianchi, Ernst Lengyel, Ugo Cavallaro
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-13 (2024)
Abstract In ovarian tumors, the omental microenvironment profoundly influences the behavior of cancer cells and sustains the acquisition of stem-like traits, with major impacts on tumor aggressiveness and relapse. Here, we leverage a patient-derived
Externí odkaz:
https://doaj.org/article/bbabde530b394fa6aa21455619c9f3bc
Autor:
Claudio Peter D’Incal, Kirsten Esther Van Rossem, Kevin De Man, Anthony Konings, Anke Van Dijck, Ludovico Rizzuti, Alessandro Vitriolo, Giuseppe Testa, Illana Gozes, Wim Vanden Berghe, R. Frank Kooy
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-28 (2023)
Abstract Background Individuals affected with autism often suffer additional co-morbidities such as intellectual disability. The genes contributing to autism cluster on a relatively limited number of cellular pathways, including chromatin remodeling.
Externí odkaz:
https://doaj.org/article/4fd1319c8f87495ca67f5845e1e6e030
Autor:
Hannah M. Kolev, Avital Swisa, Elisabetta Manduchi, Yemin Lan, Rachel R. Stine, Giuseppe Testa, Klaus H. Kaestner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 4, Pp 821-839 (2023)
Background & Aims: Although trimethylation of histone H3 lysine 27 (H3K27me3) by polycomb repressive complex 2 is required for intestinal function, the role of the antagonistic process—H3K27me3 demethylation—in the intestine remains unknown. The
Externí odkaz:
https://doaj.org/article/a95e54038c994905928595d51e834d0f
Autor:
Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Alejandro López-Tobón, Erika Tenderini, Sara Sebastiani, Flavia Troglio, Michele Gabriele, Raul Bardini Bressan, Steven M. Pollard, William T. Gibson, Giuseppe Testa
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Brain organoids are becoming increasingly relevant to dissect the molecular mechanisms underlying psychiatric and neurological conditions. The in vitro recapitulation of key features of human brain development affords the unique opportunity
Externí odkaz:
https://doaj.org/article/7c5ac3db6303413cac42055c8be0e9f1
Autor:
Alejandro Andirkó, Juan Moriano, Alessandro Vitriolo, Martin Kuhlwilm, Giuseppe Testa, Cedric Boeckx
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Large-scale estimations of the time of emergence of variants are essential to examine hypotheses concerning human evolution with precision. Using an open repository of genetic variant age estimations, we offer here a temporal evaluation of v
Externí odkaz:
https://doaj.org/article/1bdd7e78991346889481c4ae822811c0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/da06caec89094097830d914450d5e97b
Autor:
Giulia Della Chiara, Federica Gervasoni, Michaela Fakiola, Chiara Godano, Claudia D’Oria, Luca Azzolin, Raoul Jean Pierre Bonnal, Giulia Moreni, Lorenzo Drufuca, Grazisa Rossetti, Valeria Ranzani, Ramona Bason, Marco De Simone, Francesco Panariello, Ivan Ferrari, Tanya Fabbris, Francesca Zanconato, Mattia Forcato, Oriana Romano, Jimmy Caroli, Paola Gruarin, Maria Lucia Sarnicola, Michelangelo Cordenonsi, Alberto Bardelli, Nicola Zucchini, Andrea Pisani Ceretti, Nicolò Maria Mariani, Andrea Cassingena, Andrea Sartore-Bianchi, Giuseppe Testa, Luca Gianotti, Enrico Opocher, Federica Pisati, Claudio Tripodo, Giuseppe Macino, Salvatore Siena, Silvio Bicciato, Stefano Piccolo, Massimiliano Pagani
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in
Externí odkaz:
https://doaj.org/article/d24dcbd0a4754b4e8fdf6d5dd0925565
Autor:
Serena Buontempo, Pasquale Laise, James M. Hughes, Sebastiano Trattaro, Vivek Das, Chantal Rencurel, Giuseppe Testa
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The Polycomb Repressive Complex 2 (PRC2) plays important roles in the epigenetic regulation of cellular development and differentiation through H3K27me3-dependent transcriptional repression. Aberrant PRC2 activity has been associated with cancer and
Externí odkaz:
https://doaj.org/article/364545fc5725480b9422d154b7645c28
Autor:
Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tis
Externí odkaz:
https://doaj.org/article/c841855db99048c2a21529c2cdc906b1