Výsledky vyhledávání - "Giuseppa Di Genova"

Chemotherapeutic Drugs may be Used to Enhance the Killing Efficacy of Human Tumor Antigen Peptide-specific CTLs

Autor: Guido Francini, Pierpaolo Correale, Marco La Placa, Gianni Gori Savellini, Giuseppa Di Genova, Maria Grazia Cusi, Susanna Mannucci, Francesco Montagnani, Giorgio Giorgi, Maria Teresa Del Vecchio, Chiara Terrosi

Publikováno v: Journal of Immunotherapy. 31:132-147

The effects of anticancer chemotherapy on antigen-specific cytotoxic T lymphocytes (CTLs) are mostly unknown. We tested the effects of cytotoxic drugs such as 5-fluorouracil, gemcitabine, and oxaliplatin on the functional activity of antigen-specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8adf3908ae6e85e5e936c2046af281
https://doi.org/10.1097/cji.0b013e31815b69c8

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5-Fluorouracil–Based Chemotherapy Enhances the Antitumor Activity of a Thymidylate Synthase–Directed Polyepitopic Peptide Vaccine

Autor: Marzio Vestri, Enzo Bonmassar, Gianni Gori Savellini, Marco La Placa, Angelo Aquino, Guido Francini, Giorgio Giorgi, François Lemonnier, Giuseppa Di Genova, Renato Urso, Maria Teresa Del Vecchio, Pierpaolo Correale, Chiara Terrosi, Maria Grazia Cusi

Publikováno v: JNCI: Journal of the National Cancer Institute. 97:1437-1445

Background: Thymidylate synthase (TS), a key enzyme in DNA synthesis, is often overexpressed in cancer cells. Some chemotherapeutic agents, such as 5-fluorouracil (5-FU), act by inhibiting TS expression. We evaluated whether a novel 28-amino acid mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66226149c1aff4743befdd38750a9fe
https://doi.org/10.1093/jnci/dji188

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Immunization with Toscana virus N-Gc proteins protects mice against virus challenge

Autor: Gianni Gori Savellini, Colomba Giorgi, Giuseppa Di Genova, Maria Grazia Cusi, Jean Denis Docquier, Paola Di Bonito, Melissa Valentini, Chiara Terrosi

Publikováno v: Virology. 375(2)

Toscana virus (TOSV) is an emerging virus, circulating in the Mediterranean area, that is responsible for aseptic meningitis, meningoencephalitis, and encephalitis. The development of a vaccine that could provide complete protection from TOSV infecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74790a0771d7b4e3af2801a088d6d9a2
https://pubmed.ncbi.nlm.nih.gov/18355889

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Immunological characterization of respiratory syncytial virus N protein epitopes recognized by human cytotoxic T lymphocytes

Autor: Giuseppa Di Genova, Gianni Gori Savellini, Chiara Terrosi, Patrizia Blardi, Maria Grazia Cusi, Pierpaolo Correale

Publikováno v: Viral immunology. 20(3)

Virus-specific cytotoxic T lymphocytes (CTLs) are crucial for the control of respiratory syncytial virus (RSV) infection. This study has identified CTL epitopes of the RSV N protein in healthy subjects. We screened the primary structure of the N prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb6d0502ccce2201c9a390fa01b35b8
https://pubmed.ncbi.nlm.nih.gov/17931110

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Anti-angiogenetic effects of immune-reconstituted influenza virosomes assembled with parathyroid hormone-related protein derived peptide vaccine

Autor: Marco La Placa, Cinzia Remondo, Pierpaolo Correale, Rinaldo Zurbriggen, Maria Teresa Del Vecchio, Maria Grazia Cusi, Mario Amacker, Chiara Terrosi, Tommaso Renieri, Giuseppa Di Genova, Guido Francini, Gianni Gori Savellini

Publikováno v: Università degli Studi di Siena-IRIS

Background C-IRIV/PTR-4 is a novel anticancer vaccine construct composed of immune-reconstituted influenza virosomes (IRIV) assembled with the PTH-rP derived peptide (PTR)-4, a synthetic CTL epitope with HLA-A(*)02.01 amino acid binding motifs. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884ead63871169fc526f234e26eaae93
https://pubmed.ncbi.nlm.nih.gov/18291576

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Efficient delivery of DNA to dendritic cells mediated by influenza virosomes

Autor: Pierpaolo Correale, Giuseppa Di Genova, Gianni Gori Savellini, Rinaldo Zurbriggen, Maria Grazia Cusi, Chiara Terrosi

Publikováno v: Università degli Studi di Siena-IRIS

In an attempt to enhance the immunological efficacy of DNA-based vaccines, we have investigated a new biological means for delivering target gene DNA directly to professional antigen presenting cells (APC), such as the dendritic cells (DC), which are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35f9259de2486f2a3832b4a2dd70de0
https://pubmed.ncbi.nlm.nih.gov/14741166

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Development of a mouse model for the study of Toscana virus pathogenesis

Autor: Maria Grazia Cusi, Melissa Valentini, Giuseppa Di Genova, Clelia Miracco, Sabrina Bartolommei, Chiara Terrosi, Marcello Valassina, Gianni Gori Savellini

Publikováno v: Università degli Studi di Siena-IRIS

Toscana virus (TOSV) has recently been recognized as an emerging virus transmitted by phlebotomus vectors, responsible for acute neurological diseases in Mediterranean countries. In our study, we demonstrated that adult Balb/c mice were susceptible t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2a115e319b248567a22efadf60704b

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