Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Giulio Navarra"'
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Akademický článek
Catch-bond mechanism of the bacterial adhesin FimH
Autor: Maximilian M. Sauer, Roman P. Jakob, Jonathan Eras, Sefer Baday, Deniz Eriş, Giulio Navarra, Simon Bernèche, Beat Ernst, Timm Maier, Rudi Glockshuber
Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Catch bonds have a role in bacterial adhesion and infection by uropathogenic E. coli.Here, the authors report crystal structures, molecular dynamics simulations, ligand binding analysis and cell tracking to characterise the catch bond interaction bet
Externí odkaz: https://doaj.org/article/15996d3b67454979a441ce96b98b7d26
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7
Carbohydrate-Lectin Interactions: An Unexpected Contribution to Affinity
Autor: Roman P. Jakob, P. Zihlmann, Said Rabbani, Timm Maier, Roland C. Preston, Bea Wagner, Katja Stangier, Giulio Navarra, Beat Ernst, Martin Smieško
Publikováno v: ChemBioChem. 18:539-544
Uropathogenic E. coli exploit the PapG-II adhesin for infecting host cells of the kidney; moreover, the expression of PapG-II located at the tip of bacterial pili has been correlated with the onset of pyelonephritis in humans, a potentially life-thre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532babd6e70aca6b0715194fa8b523ba
https://doi.org/10.1002/cbic.201600615
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8
Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets
Autor: Maximilian M. Sauer, Roman P. Jakob, Thomas Luber, Fabia Canonica, Giulio Navarra, Beat Ernst, Carlo Unverzagt, Timm Maier, Rudi Glockshuber
Publikováno v: Journal of the American Chemical Society, 141 (2)
Multivalent carbohydrate-lectin interactions at host-pathogen interfaces play a crucial role in the establishment of infections. Although competitive antagonists that prevent pathogen adhesion are promising antimicrobial drugs, the molecular mechanis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475dbddfb773b44799b1724a423ab7d
https://pubmed.ncbi.nlm.nih.gov/30543411
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9
Label-Free FimH Protein Interaction Analysis Using Silicon Nanoribbon BioFETs
Autor: Mathias Wipf, Said Rabbani, Christian Schönenberger, Michel Calame, Ralph L. Stoop, Beat Ernst, Giulio Navarra, Kristine Bedner
Publikováno v: ACS Sensors. 1:781-788
The detection of biomarkers at very low concentration and low cost is increasingly important for clinical diagnosis. Moreover, monitoring affinities for receptor-antagonist interactions by time-resolved measurements is crucial for drug discovery and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c033ab2544626a0a22858e41d929502
https://doi.org/10.1021/acssensors.6b00089
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10
Monolithic Integration of a Silicon Nanowire Field-Effect Transistors Array on a Complementary Metal-Oxide Semiconductor Chip for Biochemical Sensor Applications
Autor: Fernando Patolsky, Andreas Hierlemann, Jörg Rothe, Amir Shadmani, Paolo Livi, Yihui Chen, Moria Kwiat, Alexander Pevzner, Alexander Stettler, Giulio Navarra
Publikováno v: Analytical Chemistry. 87:9982-9990
We present a monolithic complementary metal-oxide semiconductor (CMOS)-based sensor system comprising an array of silicon nanowire field-effect transistors (FETs) and the signal-conditioning circuitry on the same chip. The silicon nanowires were fabr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a780c0b22a9890703adb9ba07c8ffd6
https://doi.org/10.1021/acs.analchem.5b02604
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