Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Giulio Mattedi"'
Autor:
Andrew B. Tobin, Gerard R. Dawson, Patrick M. Sexton, Nathan Robertson, Sophie J. Bradley, Francesca Perini, Arthur Christopoulos, James C. Errey, Barry John Teobald, John Francis William Deakin, Lisa M. Broad, Jan Liptrot, Christopher J. Langmead, K.A. Bennett, Mary Vinson, Pradeep J. Nathan, Colin Molloy, Robert M. Cooke, Edward Hurrell, Michael Browning, Krzysztof Okrasa, Jason M Brown, Giulio Mattedi, Alastair J. H. Brown, David M. Cross, Greg J. Osborne, Julie E. Cansfield, Ali Jazayeri, Christoffer Bundgaard, Stephen R. Morairty, J.C. Patel, Fiona H. Marshall, Brian D. Hudson, Prakash Rucktooa, Robert T. Smith, Keith G. Phillips, Louis Dwomoh, Chris de Graaf, Malcolm Peter Weir, Julie Warneck, Giles A. Brown, Mark Pickworth, Benjamin G. Tehan, Tim Tasker, Anushka V. Goonawardena, Miles Congreve, João M. Dias, Shahram Shahabi
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b008b7a3c01abe25b8e63fdab465cc4
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
https://ora.ox.ac.uk/objects/uuid:fc10e298-8675-4411-9af5-3cfd801f0d78
Publikováno v:
Proceedings of the National Academy of Sciences, Vol. 117, No 27 (2020) pp. 15414-15422
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Understanding the mechanisms of activation of G-protein–coupled receptors (GPCRs) is a major issue in biophysics and pharmacology. This is particularly true for peptide-activated class B receptors, which are more flexible and have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c02fad468bb335ed433d7aa60203d59
https://doi.org/10.1073/pnas.1921851117
https://doi.org/10.1073/pnas.1921851117
Autor:
Francesca Deflorian, Chris de Graaf, Jonathan S. Mason, Giulio Mattedi, Francesco Luigi Gervasio
Publikováno v:
Journal of Chemical Information and Modeling
Adenosine receptors are involved in many pathological conditions and are thus promising drug targets. However, developing drugs that target this GPCR subfamily is a challenging task. A number of drug candidates fail due to lack of selectivity which r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb6beea5f27b8d60ca8c7a3dee046af
https://doi.org/10.1021/acs.jcim.9b00298
https://doi.org/10.1021/acs.jcim.9b00298
Autor:
Alastair J H, Brown, Sophie J, Bradley, Fiona H, Marshall, Giles A, Brown, Kirstie A, Bennett, Jason, Brown, Julie E, Cansfield, David M, Cross, Chris, de Graaf, Brian D, Hudson, Louis, Dwomoh, João M, Dias, James C, Errey, Edward, Hurrell, Jan, Liptrot, Giulio, Mattedi, Colin, Molloy, Pradeep J, Nathan, Krzysztof, Okrasa, Greg, Osborne, Jayesh C, Patel, Mark, Pickworth, Nathan, Robertson, Shahram, Shahabi, Christoffer, Bundgaard, Keith, Phillips, Lisa M, Broad, Anushka V, Goonawardena, Stephen R, Morairty, Michael, Browning, Francesca, Perini, Gerard R, Dawson, John F W, Deakin, Robert T, Smith, Patrick M, Sexton, Julie, Warneck, Mary, Vinson, Tim, Tasker, Benjamin G, Tehan, Barry, Teobald, Arthur, Christopoulos, Christopher J, Langmead, Ali, Jazayeri, Robert M, Cooke, Prakash, Rucktooa, Miles S, Congreve, Malcolm, Weir, Andrew B, Tobin
Publikováno v:
Trends Pharmacol Sci
Current therapies for Alzheimer's disease seek to correct for defective cholinergic transmission by preventing the breakdown of acetylcholine through inhibition of acetylcholinesterase, these however have limited clinical efficacy. An alternative app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7763e10dd2dc92975133618856c2920a
https://pubmed.ncbi.nlm.nih.gov/35101279
https://pubmed.ncbi.nlm.nih.gov/35101279
Autor:
Etienne Decroly, Suzanne J.F. Kaptein, Romano Silvestri, Johan Neyts, Bruno Canard, Carl Graham, Sharon Spizzichino, Giulio Mattedi, Daniele Castagnolo, Wahiba Aouadi, Coralie Valle, David J. Barlow, Zakary Sule, Kate Lauder
Publikováno v:
ChemMedChem
ChemMedChem, Wiley-VCH Verlag, 2020, 15 (4), pp.385-390. ⟨10.1002/cmdc.201900533⟩
ChemMedChem, 2020, 15 (4), pp.385-390. ⟨10.1002/cmdc.201900533⟩
Chemmedchem
ChemMedChem, Wiley-VCH Verlag, 2020, 15 (4), pp.385-390. ⟨10.1002/cmdc.201900533⟩
ChemMedChem, 2020, 15 (4), pp.385-390. ⟨10.1002/cmdc.201900533⟩
Chemmedchem
The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure‐based virtual scre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1adf1f97c56e87b6c50f0009d8cb12d
https://hal.archives-ouvertes.fr/hal-02890596/document
https://hal.archives-ouvertes.fr/hal-02890596/document
Autor:
Gary W. Black, Nicola Brown, Giulio Mattedi, Daniele Castagnolo, Nicolò Scalacci, Nicholas J. Turner
Publikováno v:
Scalacci, N, Black, G, Mattedi, G, Brown, N, Turner, N & Castagnolo, D 2017, ' Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO : Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles ', ACS Catalysis, vol. 7, no. 2, pp. 1295–1300 . https://doi.org/10.1021/acscatal.6b03081
A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed. Pyrroles were synthesized by exploiting the previously unexplored aromatizing activity of monoamine oxidase enzymes (MAO-N and 6-HDNO). MAO-N/6-HDNO whole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d28f3df986c10ed687fd5a263f035e8
https://doi.org/10.1021/acscatal.6b03081
https://doi.org/10.1021/acscatal.6b03081