Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Giulio Innamorati"'
Autor:
Alessia Dallatana, Linda Cremonesi, Francesco Pezzini, Gianluca Fontana, Giulio Innamorati, Luca Giacomello
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1567 (2024)
Stem cell therapy has the potential to meet unsolved problems in tissue repair and regeneration, particularly in the neural tissues. However, an optimal source has not yet been found. Growing evidence indicates that positive effects produced in vivo
Externí odkaz:
https://doaj.org/article/d324a714984742728bd789f013fa6297
Autor:
Havish S. Kantheti, Michael A. Hale, Shreoshi Pal Choudhuri, Huocong Huang, Xu-dong Wang, Yalda Zolghadri, Giulio Innamorati, Sai Prasada Rao Manikonda, Naviya Reddy, Sarthak Reddy, Rahul K. Kollipara, Valbona Lumani, Luc Girard, Yakov Bezrukov, Pavel Demenkov, Raymond J. MacDonald, Rolf A. Brekken, Yonghao Yu, Thomas M. Wilkie
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6619 (2024)
Diagnostic markers are desperately needed for the early detection of pancreatic ductal adenocarcinoma (PDA). We describe sets of markers expressed in temporal order in mouse models during pancreatitis, PDA initiation and progression. Cell type specif
Externí odkaz:
https://doaj.org/article/ca0ca2e8a45e4004ad47086feb150789
Autor:
Alessia Dallatana, Linda Cremonesi, Maddalena Trombetta, Giulio Fracasso, Riccardo Nocini, Luca Giacomello, Giulio Innamorati
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1576 (2023)
The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monito
Externí odkaz:
https://doaj.org/article/1cea6c457f924e80ab4a69407c4f7958
Autor:
Giulio Innamorati, Thomas M. Wilkie, Giorgio Malpeli, Salvatore Paiella, Silvia Grasso, Borislav Rusev, Biagio Eugenio Leone, Maria Teresa Valenti, Luca dalle Carbonare, Samuele Cheri, Alice Giacomazzi, Marco Zanotto, Vanessa Guardini, Michela Deiana, Donato Zipeto, Michela Serena, Marco Parenti, Francesca Guzzi, Rita Teresa Lawlor, Giovanni Malerba, Antonio Mori, Giuseppe Malleo, Luca Giacomello, Roberto Salvia, Claudio Bassi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The GNA15 gene is ectopically expressed in human pancreatic ductal adenocarcinoma cancer cells. The encoded Gα15 protein can promiscuously redirect GPCR signaling toward pathways with oncogenic potential. We sought to describe the distribut
Externí odkaz:
https://doaj.org/article/93784b7c519a4fadb855ff83a5d6b591
Autor:
Giulio Innamorati, Giovanni Ridolfi, Federica Steccanella, Alice Bormetti, Alessia Dallatana, Cristina Bozzetto, Linda Ottoboni, Marzia Di Chio, Luca Giacomello
Publikováno v:
Frontiers in Bioscience-Landmark, Vol 27, Iss 8, p 249 (2022)
Background: Mesenchymal stromal cells (MSC) from bone marrow have been reported to undergo the initial phases of neural differentiation in response to an increase of intracellular cAMP. We investigated the possibility that a similar effect applies to
Externí odkaz:
https://doaj.org/article/61ead4ba6d544229b0f630ec2533b2ba
Autor:
Giulio Innamorati, Thomas M. Wilkie, Havish S. Kantheti, Maria Teresa Valenti, Luca Dalle Carbonare, Luca Giacomello, Marco Parenti, Davide Melisi, Claudio Bassi
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-15 (2018)
Abstract Background Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease present
Externí odkaz:
https://doaj.org/article/84fdabee74354cff8a20371bb2e62283
Autor:
Giamaica Conti, Martina Pitea, Riccardo Ossanna, Roberta Opri, Giada Tisci, Elisabetta Falvo, Giulio Innamorati, Esther Ghanem, Andrea Sbarbati, Pierpaolo Ceci, Giulio Fracasso
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1622 (2021)
Pancreatic cancer (PC) represents an intriguing topic for researchers. To date, the prognosis of metastasized PC is poor with just 7% of patients exceeding a five-year survival period. Thus, molecular modifications of existing drugs should be develop
Externí odkaz:
https://doaj.org/article/39a8cae188c14ca3b763e71c4222e23c
Autor:
Michela Deiana, Luca Dalle Carbonare, Michela Serena, Samuele Cheri, Simona Mutascio, Alberto Gandini, Giulio Innamorati, Pamela Lorenzi, Michela Cumerlato, Jessica Bertacco, Franco Antoniazzi, Maria Grazia Romanelli, Monica Mottes, Donato Zipeto, Maria Teresa Valenti
Publikováno v:
Cells, Vol 9, Iss 3, p 751 (2020)
Ectopic expression of RUNX2 has been reported in several tumors. In melanoma cells, the RUNT domain of RUNX2 increases cell proliferation and migration. Due to the strong link between RUNX2 and skeletal development, we hypothesized that the RUNT doma
Externí odkaz:
https://doaj.org/article/94861e385b224bbaa55d8086abaa378c
Autor:
Sajeela Ahmed, Naseer Ahmed, Alessio Rungatscher, Daniele Linardi, Bibi Kulsoom, Giulio Innamorati, Sultan Ayoub Meo, Mebratu Alebachew Gebrie, Romel Mani, Flavia Merigo, Flavia Guzzo, Giuseppe Faggian
Publikováno v:
Antioxidants, Vol 9, Iss 2, p 167 (2020)
Consumption of flavonoid-rich nutraceuticals has been associated with a reduction in coronary events. The present study analyzed the effects of cocoa flavonols on myocardial injury following acute coronary ischemia-reperfusion (I/R). A commercially a
Externí odkaz:
https://doaj.org/article/22ab82288d5d4630a4a8820cff3069d2
Autor:
Naseer Ahmed, Daniele Linardi, Ilaria Decimo, Riffat Mehboob, Mebratu A. Gebrie, Giulio Innamorati, Giovanni B. Luciani, Giuseppe Faggian, Alessio Rungatscher
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Aim: Sphingosine 1-phosphate (S1P), sphingolipid derivatives are known anti-inflammatory, anti-apoptotic, and anti-oxidant agent. S1P have been demonstrated to have a role in the cardiovascular system. The purpose of this study was to understand the
Externí odkaz:
https://doaj.org/article/b5d61a0731f34b2680a9349c7e232512