Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization

Autor: Denise Galante, Alessia Traverso, Giulio Gancia, Luca Banfi, Cristina D'Arrigo, Renata Riva, Lisa Moni, Chiara Lambruschini, Francesco Ferraro

Publikováno v: Organic & biomolecular chemistry 15 (2017): 9331–9351. doi:10.1039/c7ob02182h
info:cnr-pdr/source/autori:Lambruschini, Chiara; Galante, Denise; Moni, Lisa; Ferraro, Francesco; Gancia, Giulio; Riva, Renata; Traverso, Alessia; Banfi, Luca; D'Arrigo, Cristina/titolo:Multicomponent, fragment-based synthesis of polyphenol-containing peptidomimetics and their inhibiting activity on beta-amyloid oligomerization/doi:10.1039%2Fc7ob02182h/rivista:Organic & biomolecular chemistry/anno:2017/pagina_da:9331/pagina_a:9351/intervallo_pagine:9331–9351/volume:15

A new and short fragment-based approach towards artificial (but "natural-based") complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The resulting library of compounds has been te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0a5fe35ba188eb574cc36d65f14c5e
http://www.cnr.it/prodotto/i/381783