Zobrazeno 1 - 10
of 818
pro vyhledávání: '"Giulio F"'
Autor:
Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L. Rose, Sanjana Srinivasan, Shan Jiang, Q. Edward Chang, Ningping Feng, Jason P. Gay, Qi Wang, Jing Wang, Philip L. Lorenzi, Lucas J. Veillon, Bo Wei, John N. Weinstein, Angela K. Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A. Lyssiotis, Joseph R. Marszalek, Giulio F. Draetta, Haoqiang Ying
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumor growth and therapy resistance
Externí odkaz:
https://doaj.org/article/ef0f3fa470bc4ac8bab02e6b16959230
Autor:
Scott Woodman, Joseph Marszalek, Alexander J Lazar, Christopher Terranova, Meng He, Timothy Heffernan, Khalida Wani, Jason Gay, Phillip Andrew Futreal, Sanjana Srinivasan, Johnathon Rose, Joseph R Daniele, Michael Peoples, Rosalba Minelli, Chiu-Yi Liu, Melinda Soeung, Luigi Perelli, Dmitry Loza, Ningping Feng, Christopher P Vellano, Giulio F Draetta, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/573b4407054247a7b16dcebb66935ad8
Autor:
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Aram S. Modrek, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G. W. Verhaak, Erik P. Sulman
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-23 (2022)
Abstract Targeted cancer therapies have revolutionized treatment but their efficacies are limited by the development of resistance driven by clonal evolution within tumors. We developed “CAPTURE”, a single-cell barcoding approach to comprehensive
Externí odkaz:
https://doaj.org/article/e91108592f504fbf93459cedf14bc51e
Targeting mitochondrial respiration and the BCL2 family in high‐grade MYC‐associated B‐cell lymphoma
Autor:
Giulio Donati, Micol Ravà, Marco Filipuzzi, Paola Nicoli, Laura Cassina, Alessandro Verrecchia, Mirko Doni, Simona Rodighiero, Federica Parodi, Alessandra Boletta, Christopher P. Vellano, Joseph R. Marszalek, Giulio F. Draetta, Bruno Amati
Publikováno v:
Molecular Oncology, Vol 16, Iss 5, Pp 1132-1152 (2022)
Multiple molecular features, such as activation of specific oncogenes (e.g., MYC, BCL2) or a variety of gene expression signatures, have been associated with disease course in diffuse large B‐cell lymphoma (DLBCL), although their relationships and
Externí odkaz:
https://doaj.org/article/25494cefbbb1465b908303161ee213bd
Autor:
Francesca Citron, Ilenia Segatto, Lorena Musco, Ilenia Pellarin, Gian Luca Rampioni Vinciguerra, Giovanni Franchin, Giuseppe Fanetti, Francesco Miccichè, Vittorio Giacomarra, Valentina Lupato, Andrea Favero, Isabella Concina, Sanjana Srinivasan, Michele Avanzo, Isabella Castiglioni, Luigi Barzan, Sandro Sulfaro, Gianluigi Petrone, Andrea Viale, Giulio F Draetta, Andrea Vecchione, Barbara Belletti, Gustavo Baldassarre
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-20 (2021)
Abstract Radiotherapy (RT) plus the anti‐EGFR monoclonal antibody Cetuximab (CTX) is an effective combination therapy for a subset of head and neck squamous cell carcinoma (HNSCC) patients. However, predictive markers of efficacy are missing, resul
Externí odkaz:
https://doaj.org/article/4189e7579da4451193bc7b51838b1c81
Autor:
Daniel B. Zamler, Takashi Shingu, Laura M. Kahn, Kristin Huntoon, Cynthia Kassab, Martina Ott, Katarzyna Tomczak, Jintan Liu, Yating Li, Ivy Lai, Rocio Zorilla-Veloz, Cassian Yee, Kunal Rai, Betty Y.S. Kim, Stephanie S. Watowich, Amy B. Heimberger, Giulio F. Draetta, Jian Hu
Publikováno v:
JCI Insight, Vol 7, Iss 12 (2022)
Novel therapeutic strategies targeting glioblastoma (GBM) often fail in the clinic, partly because preclinical models in which hypotheses are being tested do not recapitulate human disease. To address this challenge, we took advantage of our previous
Externí odkaz:
https://doaj.org/article/f2d1aec989ba484691463ec5f1531b0b
Publikováno v:
Frontiers in Earth Science, Vol 8 (2020)
Early in the history of the solar system, planetesimals were differentiated into metallic cores. In some planetesimals, this differentiation took place by percolation of the denser core forming liquid through a lighter solid silicate matrix. A key fa
Externí odkaz:
https://doaj.org/article/a0370a55725840ec8a6f2ac3c9c638a6
Autor:
Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck Do, Barbara Czako, Wylie S. Palmer, Faika Mseeh, John M. Asara, Yongying Jiang, Pietro Morlacchi, Shuping Zhao, Michael Peoples, Trang N. Tieu, Marc O. Warmoes, Philip L. Lorenzi, Florian L. Muller, Ronald A. DePinho, Giulio F. Draetta, Carlo Toniatti, Philip Jones, Timothy P. Heffernan, Joseph R. Marszalek
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 469-482.e5 (2019)
Summary: The plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations. Hereditary leiomyomatosis renal cell carcinoma (HLR
Externí odkaz:
https://doaj.org/article/660db9ad25054745b8b517d4f60f4eb7
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1555-1566 (2016)
CRISPR/Cas9 induces DNA double-strand breaks that are repaired by cell-autonomous repair pathways, namely, non-homologous end-joining (NHEJ), or homology-directed repair (HDR). While HDR is absent in G1, NHEJ is active throughout the cell cycle and,
Externí odkaz:
https://doaj.org/article/c9082a5c5b7f4918990c4d489a495469
Autor:
Mauro De Donatis, Mauro Alberti, Mattia Cipicchia, Nelson Muñoz Guerrero, Giulio F. Pappafico, Sara Susini
Publikováno v:
ISPRS International Journal of Geo-Information, Vol 9, Iss 11, p 616 (2020)
Field work on the search and characterization of ground effects of a historical earthquake (i.e., the Cagli earthquake in 1781) was carried out using terrestrial and aerial digital tools. The method of capturing, organizing, storing, and elaborating
Externí odkaz:
https://doaj.org/article/24c73862828344ff8b21b870780af1ac