Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Giulio, Rastelli"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
Traditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug. In contr
Externí odkaz:
https://doaj.org/article/4ae91223b1ad450eb2101948e648c7b8
Autor:
Luca Pinzi, Christian Conze, Nicolo Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies such as Alzheimer’s disease are characterized by aggregation and increased phosphorylation of the microtubule-associated protein tau. Tau’s pathological changes are closely linked to neurodegeneration, making tau a prime cand
Externí odkaz:
https://doaj.org/article/46bfa35f5bc64145adbe0445e00ba099
Autor:
Francesca Foschi, Annachiara Tinivella, Valentina Crippa, Luca Pinzi, Luca Mologni, Daniele Passarella, Giulio Rastelli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 239-245 (2023)
EGFR is a protein kinase whose aberrant activity is frequently involved in the development of non-small lung cancer (NSCLC) drug resistant forms. The allosteric inhibition of this enzyme is currently one among the most attractive approaches to design
Externí odkaz:
https://doaj.org/article/25d2bf8ec18e40be90168dfa859cc71c
Publikováno v:
Pharmaceuticals, Vol 17, Iss 8, p 1072 (2024)
Prostate cancer (PCA) is one of the most prevalent types of male cancers. While current treatments for early-stage PCA are available, their efficacy is limited in advanced PCA, mainly due to drug resistance or low efficacy. In this context, novel val
Externí odkaz:
https://doaj.org/article/1b5f221e610d41e89efa6d4519ca6da0
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Prostate cancer is the most common type of cancer in men. The disease presents good survival rates if treated at the early stages. However, the evolution of the disease in its most aggressive variant remains without effective therapeutic ans
Externí odkaz:
https://doaj.org/article/92da56affb65416f86ac1edf1c2c6641
Publikováno v:
Molecules, Vol 29, Iss 3, p 722 (2024)
Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) represent two among the most frequent neurodegenerative diseases worldwide. A common hallmark of these pathologies is the misfolding and consequent aggregation of amyloid proteins into soluble
Externí odkaz:
https://doaj.org/article/3aadc38507df4468b1dc6580b9c36281
Autor:
Dr. Luca Pinzi, Dr. Francesca Foschi, Dr. Michael S. Christodoulou, Prof. Daniele Passarella, Prof. Giulio Rastelli
Publikováno v:
ChemistryOpen, Vol 10, Iss 12, Pp 1177-1185 (2021)
Abstract The design of multi‐target ligands has become an innovative approach for the identification of effective therapeutic treatments against complex diseases, such as cancer. Recent studies have demonstrated that the combined inhibition of Hsp9
Externí odkaz:
https://doaj.org/article/59f20044e5544d4f89461b3db0108003
Publikováno v:
ACS Omega, Vol 6, Iss 34, Pp 21843-21849 (2021)
Externí odkaz:
https://doaj.org/article/35cb15fe9cdc42febac54efebc4f67d9
Publikováno v:
Molecules, Vol 28, Iss 11, p 4544 (2023)
Tau is a protein characterized by large structural portions displaying extended conformational changes. Unfortunately, the accumulation of this protein into toxic aggregates in neuronal cells leads to a number of severe pathologies, collectively name
Externí odkaz:
https://doaj.org/article/0e122fc5bd4d46f2b559338567e4a0b0
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract The development of selective inhibitors of the clinically relevant human Carbonic Anhydrase (hCA) isoforms IX and XII has become a major topic in drug research, due to their deregulation in several types of cancer. Indeed, the selective inhi
Externí odkaz:
https://doaj.org/article/a8f783afe9d04978a1995322e1fb4ec0