Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Giulio, Poli"'
Autor:
Miriana Di Stefano, Salvatore Galati, Lisa Piazza, Francesca Gado, Carlotta Granchi, Marco Macchia, Antonio Giordano, Tiziano Tuccinardi, Giulio Poli
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
We present a new computational approach, named Watermelon, designed for the development of pharmacophore models based on receptor structures. The methodology involves the sampling of potential hotspots for ligand interactions within a protein target
Externí odkaz:
https://doaj.org/article/3961fed658e1472d8c4b064e407e4d66
Autor:
Hannah Åbacka, Samuele Masoni, Giulio Poli, Peng Huang, Francesco Gusso, Carlotta Granchi, Filippo Minutolo, Tiziano Tuccinardi, Anna K. Hagström-Andersson, Karin Lindkvist-Petersson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant proliferation of myeloid blasts in the bone marrow and impaired normal hematopoiesis
Externí odkaz:
https://doaj.org/article/ea900aef07be4cb98d6a67af45956451
Autor:
Giulio Poli, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
hRPE65 is a fundamental enzyme of the retinoid visual cycle, and many missense mutations affecting its expression or function are associated with a wide range of diseases. Many hRPE65 missense mutations lack a clear pathogenicity classification or ar
Externí odkaz:
https://doaj.org/article/7c89f3b7f8fb4854b84bd0e0b60daf9f
Autor:
Giulio Poli, Ivana Barravecchia, Gian Carlo Demontis, Andrea Sodi, Alessandro Saba, Stanislao Rizzo, Marco Macchia, Tiziano Tuccinardi
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1765-1772 (2022)
The human retinal pigment epithelium-specific 65-kDa protein (hRPE65) plays a crucial role within the retinoid visual cycle and several mutations affecting either its expression level or its enzymatic function are associated with inherited retinal di
Externí odkaz:
https://doaj.org/article/32ce20e5e4674bca8efb26b1a3d728b6
Autor:
Emanuela Berrino, Simone Carradori, Fabrizio Carta, Francesco Melfi, Marialucia Gallorini, Giulio Poli, Tiziano Tuccinardi, José G. Fernández-Bolaños, Óscar López, Jacobus P. Petzer, Anél Petzer, Paolo Guglielmi, Daniela Secci, Claudiu T. Supuran
Publikováno v:
Antioxidants, Vol 12, Iss 12, p 2044 (2023)
Neurodegenerative disorders (NDs) include a large range of diseases characterized by neural dysfunction with a multifactorial etiology. The most common NDs are Alzheimer’s disease and Parkinson’s disease, in which cholinergic and dopaminergic sys
Externí odkaz:
https://doaj.org/article/b5a1744f71ab47be8afc72bbec67ca7a
Autor:
Giulio Poli, Miriana Di Stefano, Joan Arias Estevez, Filippo Minutolo, Carlotta Granchi, Antonio Giordano, Salvatore Parisi, Matteo Mauceri, Vincenzo Canzonieri, Marco Macchia, Isabella Caligiuri, Tiziano Tuccinardi, Flavio Rizzolio
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 145-150 (2022)
PIN1 is considered as a therapeutic target for a wide variety of tumours. However, most of known inhibitors are devoid of cellular activity despite their good enzyme inhibitory profile. Hence, the lack of effective compounds for the clinic makes the
Externí odkaz:
https://doaj.org/article/cf62bc6b195e4bc6b05154bb0957ad8b
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 365-371 (2020)
The selectivity for a specific human Carbonic Anhydrase (hCA) isoform is an important property a hCA inhibitor (CAI) should be endowed with, in order to constitute a valuable therapeutic tool for the treatment of a desired pathology. In this context,
Externí odkaz:
https://doaj.org/article/3407e248215145478682005a4ced2a2c
Autor:
Simone Carradori, Marialuigia Fantacuzzi, Alessandra Ammazzalorso, Andrea Angeli, Barbara De Filippis, Salvatore Galati, Anél Petzer, Jacobus P. Petzer, Giulio Poli, Tiziano Tuccinardi, Mariangela Agamennone, Claudiu T. Supuran
Publikováno v:
Molecules, Vol 27, Iss 22, p 7816 (2022)
Neurodegenerative diseases (NDs) are described as multifactorial and progressive syndromes with compromised cognitive and behavioral functions. The multi-target-directed ligand (MTDL) strategy is a promising paradigm in drug discovery, potentially le
Externí odkaz:
https://doaj.org/article/eca94da8116e44cf84aec1c9c2fcb8df
Autor:
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Publikováno v:
Molecules, Vol 27, Iss 19, p 6535 (2022)
Sirtuin 1 (SIRT1) is a NAD+-dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. In recent years, SIRT1-activating compounds have been demonstrated to exert cardio
Externí odkaz:
https://doaj.org/article/b3bb8f1226714db5a14dbf3ee80039d3
Autor:
Laurent R. Chiarelli, Matteo Mori, Giangiacomo Beretta, Arianna Gelain, Elena Pini, Josè Camilla Sammartino, Giovanni Stelitano, Daniela Barlocco, Luca Costantino, Margherita Lapillo, Giulio Poli, Isabella Caligiuri, Flavio Rizzolio, Marco Bellinzoni, Tiziano Tuccinardi, Stefania Villa, Fiorella Meneghetti
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 823-828 (2019)
Starting from the analysis of the hypothetical binding mode of our previous furan-based hit (I), we successfully achieved our objective to replace the nitro moiety, leading to the disclosure of a new lead exhibiting a strong activity against MbtI. Ou
Externí odkaz:
https://doaj.org/article/6ba177ad0ffa4fc28c89f33af7982d70