Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Giulietta di Benedetto"'
Autor:
Liliana Felicia Iannucci, Anna Maria D’Erchia, Ernesto Picardi, Daniela Bettio, Filippo Conca, Nicoletta Concetta Surdo, Giulietta Di Benedetto, Deborah Musso, Cristina Arrigoni, Marco Lolicato, Mauro Vismara, Francesca Grisan, Leonardo Salviati, Luciano Milanesi, Graziano Pesole, Konstantinos Lefkimmiatis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The second messenger cyclic AMP regulates many nuclear processes including transcription, pre-mRNA splicing and mitosis. While most functions are attributed to protein kinase A, accumulating evidence suggests that not all nuclear cyclic AMP-
Externí odkaz:
https://doaj.org/article/77427aa5706f4cceb0df07829b118d3c
Autor:
Roberta Noè, Noemi Inglese, Patrizia Romani, Thauan Serafini, Carlotta Paoli, Beatrice Calciolari, Marco Fantuz, Agata Zamborlin, Nicoletta C. Surdo, Vittoria Spada, Martina Spacci, Sara Volta, Maria Laura Ermini, Giulietta Di Benedetto, Valentina Frusca, Claudio Santi, Konstantinos Lefkimmiatis, Sirio Dupont, Valerio Voliani, Luca Sancineto, Alessandro Carrer
Publikováno v:
Redox Biology, Vol 68, Iss , Pp 102962- (2023)
Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal functions to support growth. At the same time, this causes significant dishomeostasis of free radicals. While this is compensated by the upregulation of detoxific
Externí odkaz:
https://doaj.org/article/d721bd1f6d784b06ba59e2bcf6a3a387
Autor:
Isabella Russo, Giulietta Di Benedetto, Alice Kaganovich, Jinhui Ding, Daniela Mercatelli, Michele Morari, Mark R. Cookson, Luigi Bubacco, Elisa Greggio
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Evidence indicates a cross-regulation between two kinases, leucine-rich repeat kinase 2 (LRRK2) and protein kinase A (PKA). In neurons, LRRK2 negatively regulates PKA activity in spiny projecting neurons during synaptogenesis and
Externí odkaz:
https://doaj.org/article/3f02db1538d9430aa0ab55885b5b8ff6
Autor:
Giulietta Di Benedetto, Liliana F. Iannucci, Nicoletta C. Surdo, Sofia Zanin, Filippo Conca, Francesca Grisan, Andrea Gerbino, Konstantinos Lefkimmiatis
Publikováno v:
Cells, Vol 10, Iss 2, p 464 (2021)
The cyclic AMP (cAMP) signalling cascade is necessary for cell homeostasis and plays important roles in many processes. This is particularly relevant during ageing and age-related diseases, where drastic changes, generally decreases, in cAMP levels h
Externí odkaz:
https://doaj.org/article/649c6f8625504f8cbf83a9f9200d4ef7
Autor:
Rodrigo F Oliveira, Anna Terrin, Giulietta Di Benedetto, Robert C Cannon, Wonryull Koh, MyungSook Kim, Manuela Zaccolo, Kim T Blackwell
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11725 (2010)
Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despi
Externí odkaz:
https://doaj.org/article/9e11feaa202d4c4ba2c3f80202c229f2
Autor:
Daniela Regazzo, Loris Bertazza, Eva Galletta, Susi Barollo, Alberto Mondin, Stefania Zovato, Maurizio Iacobone, Eleonora Zilio, Carla Scaroni, Claudia Maria Radu, Giulietta di Benedetto, Caterina Mian, Konstantinos Lefkimmiatis, Gianluca Occhi
Publikováno v:
Endocrine-Related Cancer. 29:273-284
The improper expression of glucose-dependent insulinotropic polypeptide receptor (GIPR) and the GIP/GIPR axis activation has been increasingly recognized in endocrine tumors, with a potential diagnostic and prognostic value. A high tumor-to-normal ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efe13d6cbcb144a25f83d8646c4ebb5e
https://doi.org/10.1530/erc-21-0258
https://doi.org/10.1530/erc-21-0258
Autor:
Nicoletta C. Surdo, Tullio Pozzan, Konstantinos Lefkimmiatis, Liliana F. Iannucci, Giulietta Di Benedetto, Francesca Grisan, Alex Burdyga
Publikováno v:
Progress in Biophysics and Molecular Biology. 154:30-38
Cyclic 3'-5' adenosine monophosphate (cAMP) is a key modulator of cardiac function. Thanks to the sophisticated organization of its pathway in distinct functional units called microdomains, cAMP is involved in the regulation of both inotropy and chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763902f30823471cab4c55868617ce45
https://doi.org/10.1016/j.pbiomolbio.2019.06.001
https://doi.org/10.1016/j.pbiomolbio.2019.06.001
Autor:
Francesca Grisan, Nicoletta C. Surdo, Giulietta Di Benedetto, Liliana F. Iannucci, Tullio Pozzan, Konstantinos Lefkimmiatis
Publikováno v:
Aging Clinical and Experimental Research. 33:1367-1370
Mitochondria constantly contribute to the cell homeostasis and this, during the lifespan of a cell, takes its toll. Indeed, the functional decline of mitochondria appears correlated to the aging of the cell. The initial idea was that excessive produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b16e266650a66eb4f29fd3e427bd272
https://doi.org/10.1007/s40520-019-01451-9
https://doi.org/10.1007/s40520-019-01451-9
Autor:
Martina La Spina, Michele Azzolini, Andrea Salmaso, Sofia Parrasia, Eva Galletta, Marco Schiavone, Martina Chrisam, Andrea Mattarei, Giulietta Di Benedetto, Andrea Ballabio, Natascia Tiso, Mario Zoratti, Lucia Biasutto
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Pterostilbene (Pt) is a potentially beneficial plant phenol. In contrast to many other natural compounds (including the more celebrated resveratrol), Pt concentrations producing significant effects in vitro can also be reached with relative ease in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5ec9e6a7f9de41602af2d94592decd
http://hdl.handle.net/11577/3410259
http://hdl.handle.net/11577/3410259
Publikováno v:
Cell calcium. 93
Cytosolic cAMP signalling in live cells has been extensively investigated in the past, while only in the last decade the existence of an intramitochondrial autonomous cAMP homeostatic system began to emerge. Thanks to the development of novel tools t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20055e7b3ca7b0119d0a0e1aa499d9bb
https://pubmed.ncbi.nlm.nih.gov/33296837
https://pubmed.ncbi.nlm.nih.gov/33296837