Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Giuliano Marzola"'
Autor:
Stefano Molinari, Giuliano Marzola, Girolamo Calo, Remo Guerrini, S. Salvadori, Paola Molinari, John McDonald, Mei-Chuan Ko, Anna Rizzi, Camarda, Erika Marzola, David G. Lambert
Publikováno v:
British Journal of Pharmacology. 168:151-162
Background and Purpose Intrathecally (i.t.) administered nociceptin/orphanin FQ (N/OFQ) evokes antinociceptive effects in rodents. Recent studies in monkeys demonstrated that i.t. co-application of N/OFQ and morphine elicits synergistic antinocicepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2ae93f7e656376e1805efd77ece2bdf
https://doi.org/10.1111/j.1476-5381.2012.02115.x
https://doi.org/10.1111/j.1476-5381.2012.02115.x
Publikováno v:
Neuropharmacology. 62:1999-2009
Neuropeptide S (NPS) is the endogenous ligand of a previously orphan receptor now named NPSR. In the brain NPS regulates several biological functions including anxiety, arousal, locomotion, food intake, learning and memory, pain and drug abuse. Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861ad5b5d591b6e763eb9feb4dc6e495
https://doi.org/10.1016/j.neuropharm.2011.12.036
https://doi.org/10.1016/j.neuropharm.2011.12.036
Autor:
Claudio Trapella, Anna Rizzi, Giuliano Marzola, Remo Guerrini, Jorgen S. Petersen, Carmela Fischetti, Elaine C. Gavioli, Girolamo Calo
Publikováno v:
Peptides. 30:248-255
ZP120 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) ligand. In previous studies, the effects of ZP120 were found to be sensitive to J-113397 in mouse tissues while resistant to UFP-101 in rat tissues. The aim of this study was to further
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72d1b5e5ebaa2f5b44fdd2368a291db
https://doi.org/10.1016/j.peptides.2008.10.001
https://doi.org/10.1016/j.peptides.2008.10.001
Autor:
Mauro Marastoni, Severo Salvadori, Giuliano Marzola, Ettore Ciro Degliuberti, Gianfranco Balboni, Roberto Tomatis
Publikováno v:
International Journal of Peptide and Protein Research. 28:274-281
Dermorphinoyl(DMR)-glycine, DMR-sarcosine and DMR-glycyl-arginine have been prepared in order to examine the effect of C-terminal extension of dermorphin (H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2) on opioid activity. On GPI preparation the addition of Gly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc577cd92c95a152c219406c56fa43b
https://doi.org/10.1111/j.1399-3011.1986.tb03256.x
https://doi.org/10.1111/j.1399-3011.1986.tb03256.x
Autor:
Rainer K. Reinscheid, Remo Guerrini, Erika Marzola, Anna Rizzi, Chiara Ruzza, Girolamo Calo, Severo Salvadori, Domenico Regoli, Giuliano Marzola, Valeria Camarda, Silvia Zucchini
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:549-555
Neuropeptide S (NPS) was identified as the endogenous ligand of an orphan receptor now referred to as the NPS receptor (NPSR). In the frame of a structure-activity study performed on NPS Gly5, the NPSR ligand [d-Cys(tBu)5]NPS was identified. [d-Cys(t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0227192c48cbdd263f813c1d6420b478
https://doi.org/10.1124/jpet.108.143867
https://doi.org/10.1124/jpet.108.143867
Autor:
Anna Rizzi, Domenico Regoli, Chiara Ruzza, Remo Guerrini, Girolamo Calo, Giuliano Marzola, Severo Salvadori, Raffaella Vergura
Publikováno v:
British Journal of Pharmacology. 154:471-479
Background and purpose: Neuropeptide S (NPS) was recently identified as the endogenous ligand of an orphan receptor, now referred to as the NPS receptor. In vivo, NPS produces a unique behavioural profile by increasing wakefulness and exerting anxiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2612cecd51e40bc12ff87a52f4dab9ee
https://doi.org/10.1038/bjp.2008.96
https://doi.org/10.1038/bjp.2008.96
Autor:
Richard D Wainford, Anna Rizzi, Girolamo Calo, Remo Guerrini, Severo Salvadori, Anna Baldisserotto, Giuliano Marzola, Carmela Fischetti, Daniel R. Kapusta, Domenico Regoli, Barbara Spagnolo
Publikováno v:
Peptides. 28:1240-1251
[(pF)Phe 4 Aib 7 Arg 14 Lys 15 ]N/OFQ-NH 2 (UFP-112) has been designed as a novel ligand for the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) by combining into the same peptide different chemical modifications reported to increase N/OFQ pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c1bdf4ac682a9b8f3b4bc53ffd3033
https://doi.org/10.1016/j.peptides.2007.04.020
https://doi.org/10.1016/j.peptides.2007.04.020
Autor:
Anna Rizzi, Elaine C. Gavioli, Giuliano Marzola, Barbara Spagnolo, Silvia Zucchini, Roberto Ciccocioppo, Claudio Trapella, Domenico Regoli, Girolamo Calò
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:968-974
The excellent pharmacological profile displayed by the selective nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119ef31df537cca8fee865aa9754ecb4
https://doi.org/10.1124/jpet.106.116780
https://doi.org/10.1124/jpet.106.116780
Autor:
Silvia Vertuani, Stefano Manfredini, Martina Scaglianti, Giuliano Marzola, Angelo Scatturin, Federica Vitali, Luca Ferraro, Carla Biondi, Barbara Pavan, Alessandro Dalpiaz, Puttur D. Prasad, Fabrizio Bortolotti, Sergio Tanganelli
Publikováno v:
European Journal of Pharmaceutical Sciences. 24:259-269
Ascorbic acid (AA) or 6-Br-ascorbate (BrAA) conjugation has been investigated as a tool to improve brain drug delivery by the Vitamin C transporter SVCT2. To this aim, the effects of AA- or BrAA-conjugation on drug affinity and uptake have been asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fde07739b263186a464f21741e505d2
https://doi.org/10.1016/j.ejps.2004.10.014
https://doi.org/10.1016/j.ejps.2004.10.014
Autor:
Giuliano Marzola, Rosalia Bertorelli, Domenico Regoli, Elaine C. Gavioli, Giles A. Rae, S. Salvadori, Silvia Zucchini, Girolamo Calo, Remo Guerrini, T.C.M. De Lima
Publikováno v:
European Journal of Neuroscience. 17:1987-1990
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor, regulates several central functions such as pain transmission, learning and memory, fear and anxiety and feeding and locomotor activity. It has been recently reported that NOP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb112f9bb966f9635de2fbc78f7e99fa
https://doi.org/10.1046/j.1460-9568.2003.02603.x
https://doi.org/10.1046/j.1460-9568.2003.02603.x