Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Giuliano Malloci"'
Autor:
Alessio Macorano, Angelica Mazzolari, Giuliano Malloci, Alessandro Pedretti, Giulio Vistoli, Silvia Gervasoni
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-7 (2024)
Abstract In silico prediction of xenobiotic metabolism is an important strategy to accelerate the drug discovery process, as candidate compounds often fail in clinical phases due to their poor pharmacokinetic profiles. Here we present MetaQM, a datas
Externí odkaz:
https://doaj.org/article/bf9144306a574b90a9c3a84c8d8d3311
Autor:
Pedro D. Manrique, Inga V. Leus, César A. López, Jitender Mehla, Giuliano Malloci, Silvia Gervasoni, Attilio V. Vargiu, Rama K. Kinthada, Liam Herndon, Nicolas W. Hengartner, John K. Walker, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya, S. Gnanakaran
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract The ability Gram-negative pathogens have at adapting and protecting themselves against antibiotics has increasingly become a public health threat. Data-driven models identifying molecular properties that correlate with outer membrane (OM) pe
Externí odkaz:
https://doaj.org/article/45d6aee426a544c597e58b71c5e0adb4
Autor:
Işılay Öztürk, Silvia Gervasoni, Camilla Guccione, Andrea Bosin, Attilio Vittorio Vargiu, Paolo Ruggerone, Giuliano Malloci
Publikováno v:
Molecules, Vol 29, Iss 18, p 4416 (2024)
Radiopharmaceuticals are currently a key tool in cancer diagnosis and therapy. Metal-based radiopharmaceuticals are characterized by a radiometal–chelator moiety linked to a bio-vector that binds the biological target (e.g., a protein overexpressed
Externí odkaz:
https://doaj.org/article/6b39876ac8444575be11f76941b98f7f
Autor:
Silvia Gervasoni, Camilla Guccione, Viviana Fanti, Andrea Bosin, Giancarlo Cappellini, Bruno Golosio, Paolo Ruggerone, Giuliano Malloci
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract The cyclic peptide hormone somatostatin regulates physiological processes involved in growth and metabolism, through its binding to G-protein coupled somatostatin receptors. The isoform 2 (SSTR2) is of particular relevance for the therapy of
Externí odkaz:
https://doaj.org/article/a473b2ddca09409ba9267aabd6afda3a
Autor:
Julia Vergalli, Hugo Chauvet, Francesco Oliva, Jelena Pajović, Giuliano Malloci, Attilio Vittorio Vargiu, Matthieu Réfrégiers, Paolo Ruggerone, Jean-Marie Pagès
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
A competitive efflux assay combined with computational approaches reveal how different quinolones interact with the prototypical bacterial multidrug efflux transporter AcrB, providing insights which may help optimise antibiotics.
Externí odkaz:
https://doaj.org/article/9ea12524a8cd497c89d5c583e95f6c7d
Autor:
Silvia Gervasoni, Jitender Mehla, Charles R. Bergen, Inga V. Leus, Enrico Margiotta, Giuliano Malloci, Andrea Bosin, Attilio V. Vargiu, Olga Lomovskaya, Valentin V. Rybenkov, Paolo Ruggerone, Helen I. Zgurskaya
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Transporters of the resistance-nodulation-cell division (RND) superfamily of proteins are the dominant multidrug efflux power of Gram-negative bacteria. The major RND efflux pump of Pseudomonas aeruginosa is MexAB-OprM, in which the inner me
Externí odkaz:
https://doaj.org/article/09f8ee5600f347ba91948b10681d1d33
Autor:
Silvia Gervasoni, Giuliano Malloci, Andrea Bosin, Attilio V. Vargiu, Helen I. Zgurskaya, Paolo Ruggerone
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-12 (2022)
Measurement(s) molecular physical property analysis objective Technology Type(s) Computer Modeling
Externí odkaz:
https://doaj.org/article/c60297b5a8cc4382882c3b150273e333
Autor:
Pierpaolo Cacciotto, Andrea Basciu, Francesco Oliva, Giuliano Malloci, Martin Zacharias, Paolo Ruggerone, Attilio V. Vargiu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 252-260 (2022)
Efflux pumps of the Resistance-Nodulation-cell Division (RND) superfamily contribute to intrinsic and acquired resistance in Gram-negative pathogens by expelling chemically unrelated antibiotics with high efficiency. They are tripartite systems const
Externí odkaz:
https://doaj.org/article/8853a43188d94088885459276f986732
Autor:
Coline Plé, Heng-Keat Tam, Anais Vieira Da Cruz, Nina Compagne, Juan-Carlos Jiménez-Castellanos, Reinke T. Müller, Elizabeth Pradel, Wuen Ee Foong, Giuliano Malloci, Alexia Ballée, Moritz A. Kirchner, Parisa Moshfegh, Adrien Herledan, Andrea Herrmann, Benoit Deprez, Nicolas Willand, Attilio Vittorio Vargiu, Klaas M. Pos, Marion Flipo, Ruben C. Hartkoorn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, the authors identify pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through allosteric inhibition of it
Externí odkaz:
https://doaj.org/article/2d5e83c99b5c4265bf969d47fed84ba5
Autor:
Alina Ornik-Cha, Julia Wilhelm, Jessica Kobylka, Hanno Sjuts, Attilio V. Vargiu, Giuliano Malloci, Julian Reitz, Anja Seybert, Achilleas S. Frangakis, Klaas M. Pos
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight
Externí odkaz:
https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a6795