Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Giuliano Giuseppe Stirparo"'
Autor:
Nicholas Bredenkamp, Jian Yang, James Clarke, Giuliano Giuseppe Stirparo, Ferdinand von Meyenn, Sabine Dietmann, Duncan Baker, Rosalind Drummond, Yongming Ren, Dongwei Li, Chuman Wu, Maria Rostovskaya, Sarah Eminli-Meissner, Austin Smith, Ge Guo
Publikováno v:
Stem Cell Reports, Vol 13, Iss 6, Pp 1083-1098 (2019)
Summary: In contrast to conventional human pluripotent stem cells (hPSCs) that are related to post-implantation embryo stages, naive hPSCs exhibit features of pre-implantation epiblast. Naive hPSCs are established by resetting conventional hPSCs, or
Externí odkaz:
https://doaj.org/article/95ece9067a1341efb303004330857da9
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1212-1222 (2019)
Summary: Recently naive human pluripotent stem cells (hPSCs) have been described that relate to an earlier stage of development than conventional hPSCs. Naive hPSCs remain challenging to generate and authenticate, however. Here we report that Sushi C
Externí odkaz:
https://doaj.org/article/b5368755c01d4c8893f6cb3bf9453675
Autor:
Davide A. D. Cassani, Jennifer Nichols, Raphael Blumenfeld, Irene M. Aspalter, Ruby Peters, Henry De Belly, Kevin J. Chalut, Giuliano Giuseppe Stirparo, Ayaka Yanagida, Ewa K. Paluch, Christopher Revell, Elena Corujo-Simon, Sarra Achouri, Kristian Franze
Publikováno v:
Cell
In development, lineage segregation of multiple lineages must be coordinated in time and space. An important example is the mammalian inner cell mass (ICM), in which the primitive endoderm (PrE, founder of the yolk sac) physically segregates from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faa50992492321a92f691b29c76cc5a
https://www.repository.cam.ac.uk/handle/1810/333532
https://www.repository.cam.ac.uk/handle/1810/333532
Autor:
Masaki Kinoshita, Toshihiro Kobayashi, Benjamin Planells, Doris Klisch, Daniel Spindlow, Hideki Masaki, Susanne Bornelöv, Giuliano Giuseppe Stirparo, Hitomi Matsunari, Ayuko Uchikura, Ismael Lamas-Toranzo, Jennifer Nichols, Hiromitsu Nakauchi, Hiroshi Nagashima, Ramiro Alberio, Austin Smith
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
article-version (VoR) Version of Record
Development
Despite four decades of effort, robust propagation of pluripotent stem cells from livestock animals remains challenging. The requirements for self-renewal are unclear and the relationship of cultured stem cells to pluripotent cells resident in the em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::221cdf8daabfad5aa8e45ee7468174a3
https://doi.org/10.1242/dev.199901
https://doi.org/10.1242/dev.199901
Autor:
Bao Xiu Tan, Céline Labouesse, Carla Mulas, Alexander K. Winkel, Moritz Hofer, Christophe M. Verstreken, Chibeza C. Agley, Kevin J. Chalut, José C. R. Silva, Giuliano Giuseppe Stirparo, Paul Bertone, Kristian Franze, William Mansfield, Hannah T. Stuart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Funder: Medical Research Council (UK) Career Development Award (G1100312/1)
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db56a2eb87774cd06d0a784eb5336e
https://www.repository.cam.ac.uk/handle/1810/329719
https://www.repository.cam.ac.uk/handle/1810/329719
Autor:
Petra van der Lelij, Laura Santini, Henry Fabian Thomas, Meryem Ralser, Elena Galimberti, Mihail Sarov, Marius Garmhausen, Martin Leeb, Andreas Beyer, Giuliano Giuseppe Stirparo, A. Francis Stewart, Fabian Titz-Teixeira, Robert Sehlke, Julia Ramesmayer, Andreas Lackner, Michelle Huth, Austin Smith
Publikováno v:
The EMBO Journal
In the mammalian embryo, epiblast cells must exit the naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0966c58bbd48ebd2a844aa6b6913cd
https://doi.org/10.15252/embj.2020105776
https://doi.org/10.15252/embj.2020105776
Autor:
Lawrence E. Bates, Jennifer Nichols, José C. R. Silva, Thorsten Boroviak, Giuliano Giuseppe Stirparo, Siarhei Hladkou, Agata Kurowski, Hannah T. Stuart, Stanley E. Strawbridge, Ayaka Yanagida
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo. Surprisingly, most pluripotency-associated factors are induced norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43e422ba3658d70d42d43bde35188c7
https://doi.org/10.1073/pnas.2008890118
https://doi.org/10.1073/pnas.2008890118
Autor:
Martin Leeb, Robert Sehlke, Petra van der Lelij, A. Francis Stewart, Marius Garmhausen, Mihail Sarov, Andreas Lackner, Henry Fabian Thomas, Julia Ramesmayer, Laura Santini, Andreas Beyer, Michelle Huth, Fabian Titz-Teixeira, Austin Smith, Giuliano Giuseppe Stirparo, Meryem Ralser
In the mammalian embryo, epiblast cells must exit their naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fae4c4df10a6b6c736e6c4a925f1289
https://doi.org/10.1101/2020.03.23.000109
https://doi.org/10.1101/2020.03.23.000109
Autor:
Anish Dattani, Stanley E. Strawbridge, Daniel Spindlow, Ayaka Yanagida, Meng Amy Li, Jennifer Nichols, Buse Nurten Özel, Sam Myers, Ge Guo, Austin Smith, Giuliano Giuseppe Stirparo, Jian Yang, James Clarke
SUMMARYClassical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryonic trophecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc8f857a914f86324d8e62366c2c8a19
https://doi.org/10.1101/2020.02.04.933812
https://doi.org/10.1101/2020.02.04.933812
Autor:
Giuliano Giuseppe Stirparo, Katsiaryna Maskalenka, Amanda Andersson-Rolf, Kathryn C Tremble, Hannah T. Stuart, Kenneth Jones, José C. R. Silva, Bon-Kyoung Koo, Paul Bertone, Aliaksandra Radzisheuskaya, Lawrence E. Bates
Publikováno v:
iScience
iScience, Vol 24, Iss 3, Pp 102153-(2021)
iScience, Vol 24, Iss 3, Pp 102153-(2021)
Summary Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da78d938dba8b4663cfaeeb6a3801f1