Výsledky vyhledávání - "Giuliano Cutolo"

Akademický článek

Artificial Fluorescent Glucosinolates (F-GSLs) Are Transported by the Glucosinolate Transporters GTR1/2/3

Autor: Christa Kanstrup, Claire C. Jimidar, Josip Tomas, Giuliano Cutolo, Christoph Crocoll, Marie Schuler, Philipp Klahn, Arnaud Tatibouët, Hussam Hassan Nour-Eldin

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 2, p 920 (2023)

The glucosinolate transporters 1/2/3 (GTR1/2/3) from the Nitrate and Peptide transporter Family (NPF) play an essential role in the transport, accumulation, and distribution of the specialized plant metabolite glucosinolates. Due to representing both

Externí odkaz: https://doaj.org/article/26256b7651dd45d3881bf6c4b85fc645

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Akademický článek

O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins

Autor: Narek Darabedian, Bo Yang, Richie Ding, Giuliano Cutolo, Balyn W. Zaro, Christina M. Woo, Matthew R. Pratt

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Monosaccharide analogs bearing bioorthogonal functionalities, or metabolic chemical reporters (MCRs) of glycosylation, have been used for approximately two decades for the visualization and identification of different glycoproteins. More recently, pr

Externí odkaz: https://doaj.org/article/9af1763064db4c8484cd82331fd5bd1c

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Comparison of N-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation

Autor: Aaron T. Balana, Ricardo Palos Pacheco, Matthew R. Pratt, Ananya Rakshit, Ana Galesic, Giuliano Cutolo, Stuart P. Moon

Publikováno v: ACS Chemical Biology. 16:14-19

O-GlcNAc modification of the microtubule associated protein tau and α-synuclein can directly inhibit the formation of the associated amyloid fibers associated with major classes of neurodegenerative diseases. However, the mechanism(s) by which this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cfce5b1c4dabc9d1d8948db793f3bcc
https://doi.org/10.1021/acschembio.0c00716

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4-Deoxy-4-fluoro-GalNAz (4FGalNAz) Is a Metabolic Chemical Reporter of O-GlcNAc Modifications, Highlighting the Notable Substrate Flexibility of O-GlcNAc Transferase

Autor: Emma G. Jackson, Giuliano Cutolo, Bo Yang, Nageswari Yarravarapu, Mary W. N. Burns, Ganka Bineva-Todd, Chloë Roustan, James B. Thoden, Halley M. Lin-Jones, Toin H. van Kuppevelt, Hazel M. Holden, Benjamin Schumann, Jennifer J. Kohler, Christina M. Woo, Matthew R. Pratt

Publikováno v: Acs Chemical Biology, 17, 159-170
ACS Chemical Biology
Acs Chemical Biology, 17, 1, pp. 159-170

Bio-orthogonal chemistries have revolutionized many fields. For example, metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain a bio-orthogonal functionality, such as azides or alkynes. MCRs are metabolica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6b42fdce89cd311e21d1c951f3f50
http://hdl.handle.net/2066/247897

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Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

Autor: Reine Nehmé, Cyrille Sabot, Arnaud Tatibouët, Hélène Castel, Marie Hubert-Roux, Giuliano Cutolo, Pierre-Yves Renard, Benjamin Poret, Marie Schuler, Jean Wilfried Fredy, Pierrick Gandolfo

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, 2019, 30 (5), pp.1385-1394. ⟨10.1021/acs.bioconjchem.9b00153⟩
Bioconjugate Chemistry, American Chemical Society, 2019, 30 (5), pp.1385-1394. ⟨10.1021/acs.bioconjchem.9b00153⟩

International audience; Fluorescein isothiocyanate (FITC) is one of the most extensively used fluorescent probes for the labeling of biomolecules. The isothiocyanate function reacts with lysine residues of proteins to provide a chemically stable thio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efb5184da913b466f756d8218abbafc
https://doi.org/10.1021/acs.bioconjchem.9b00153

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Comparison of

Autor: Ana, Galesic, Ananya, Rakshit, Giuliano, Cutolo, Ricardo Palos, Pacheco, Aaron T, Balana, Stuart P, Moon, Matthew R, Pratt

Publikováno v: ACS Chem Biol

O-GlcNAc modification of tau and α-synuclein can directly inhibit the formation of the associated amyloid fibers associated with major classes of neurodegenerative diseases. However, the mechanism(s) by which this posttranslational modification inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ee21f12e436f1b774955fe488b37fa3
https://pubmed.ncbi.nlm.nih.gov/33399442

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Synthesis of glycosyl sulfoximines by a highly chemo- And stereoselective NH- And O-transfer to thioglycosides

Autor: Claudia Carlucci, Patrick Rollin, James A. Bull, Arianna Tota, Giuliano Cutolo, Luisa Pisano, Renzo Luisi, Giuseppe Romanazzi, Guy J. Clarkson, Leonardo Degennaro

A synthesis of unprecedented and stable glycosyl sulfoximines is reported. The developed strategies represent the first example of highly stereoselective sulfoximine formation directly from thioglycosides. This synthetic protocol has been tested on s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dab0661dc880173bca06346b1e2f4e
http://hdl.handle.net/11589/202090

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4-Amino-1,2,4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 208, pp.112720. ⟨10.1016/j.ejmech.2020.112720⟩

Resistance to β-lactam antibiotics in Gram-negatives producing metallo-β-lactamases (MBLs) represents a major medical threat and there is an extremely urgent need to develop clinically useful inhibitors. We previously reported the original binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2a1524597920cd19b370374d73dec9
http://hdl.handle.net/11365/1120638

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Your mother was right, washing matters: An alkyne-analog of ibuprofen reveals unwanted reactivity of aromatic compounds with proteins during copper-catalyzed click chemistry

Autor: Sahiti N. Shankar, Giuliano Cutolo, Matthew R. Pratt

Publikováno v: Bioorg Med Chem Lett

Bioorthogonal chemistry, in particular the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), has enabled the robust identification of covalent protein targets of probes and drugs. Ibuprofen is commonly used pain and fever reducer and is sold as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95e2ab4398051d9f2ab9e150ba59106
https://doi.org/10.1016/j.bmcl.2021.128260

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Capillary electrophoresis with dual detection UV/C4D for monitoring myrosinase-mediated hydrolysis of thiol glucosinolate designed for gold nanoparticle conjugation

Autor: Irina Zarafu, Reine Nehmé, Giuliano Cutolo, Philippe Morin, Petre Ionita, Arnaud Tatibouët, Amal Farhat, Marie Schuler, Bérengère Claude

Publikováno v: Analytica Chimica Acta
Analytica Chimica Acta, Elsevier Masson, 2019, 1085, pp.117-125. ⟨10.1016/j.aca.2019.07.043⟩
Analytica Chimica Acta, 2019, 1085, pp.117-125. ⟨10.1016/j.aca.2019.07.043⟩

Capillary electrophoresis (CE) with dual UV and conductivity detection was used for the first time to monitor the functionalization of gold nanoparticles (AuNPs), a process catalyzed by an enzyme, myrosinase (Myr). A thiol glucosinolate (GL-SH) desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c1b5d7b1a51b07bc2c33b425a8d36f
https://hal.archives-ouvertes.fr/hal-03487875

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