Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Autor: Will J. R. Stone, Joseph J. Campo, André Lin Ouédraogo, Lisette Meerstein-Kessel, Isabelle Morlais, Dari Da, Anna Cohuet, Sandrine Nsango, Colin J. Sutherland, Marga van de Vegte-Bolmer, Rianne Siebelink-Stoter, Geert-Jan van Gemert, Wouter Graumans, Kjerstin Lanke, Adam D. Shandling, Jozelyn V. Pablo, Andy A. Teng, Sophie Jones, Roos M. de Jong, Amanda Fabra-García, John Bradley, Will Roeffen, Edwin Lasonder, Giuliana Gremo, Evelin Schwarzer, Chris J. Janse, Susheel K. Singh, Michael Theisen, Phil Felgner, Matthias Marti, Chris Drakeley, Robert Sauerwein, Teun Bousema, Matthijs M. Jore

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Naturally acquired antibodies may inhibit Plasmodium survival in mosquitoes, alter malaria transmission dynamics, and form the basis for transmission-blocking vaccines. Here, using sera from malaria-exposed individuals, Stone et al. reveal novel anti

Externí odkaz: https://doaj.org/article/a727fd054ca84e01a19890f2a0ecb7bd

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

Autor: Phil Felgner, Marga van de Vegte-Bolmer, Wouter Graumans, Chris J. Janse, Michael Theisen, Chris Drakeley, Sandrine E. Nsango, Matthijs M. Jore, Dari Da, Andy Teng, Giuliana Gremo, Rianne Siebelink-Stoter, John S. Bradley, Will Stone, Lisette Meerstein-Kessel, Edwin Lasonder, Isabelle Morlais, Will Roeffen, Amanda Fabra-García, Anna Cohuet, Adam D. Shandling, Jozelyn Pablo, Evelin Schwarzer, Susheel K. Singh, Roos M. de Jong, Kjerstin Lanke, Teun Bousema, Geert-Jan van Gemert, Joseph J. Campo, Matthias Marti, Colin J. Sutherland, André Lin Ouédraogo, Robert W. Sauerwein, Sophie Jones

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-017-02646-2⟩
Nature Communications, 9, pp.
Stone, W J R, Campo, J J, Ouédraogo, A L, Meerstein-Kessel, L, Morlais, I, Da, D, Cohuet, A, Nsango, S, Sutherland, C J, van de Vegte-Bolmer, M, Siebelink-Stoter, R, van Gemert, G-J, Graumans, W, Lanke, K, Shandling, A D, Pablo, J V, Teng, A A, Jones, S, de Jong, R M, Fabra-García, A, Bradley, J, Roeffen, W, Lasonder, E, Gremo, G, Schwarzer, E, Janse, C J, Singh, S K, Theisen, M, Felgner, P, Marti, M, Drakeley, C, Sauerwein, R, Bousema, T & Jore, M M 2018, ' Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity ', Nature Communications, vol. 9, no. 1, 558 . https://doi.org/10.1038/s41467-017-02646-2
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-017-02646-2⟩
Nature Communications, 9,
Nature Communications, 9
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Infection with Plasmodium can elicit antibodies that inhibit parasite survival in the mosquito, when they are ingested in an infectious blood meal. Here, we determine the transmission-reducing activity (TRA) of naturally acquired antibodies from 648

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59bdac78b8686ff84b8ce6bfaf9bddc
https://hal.ird.fr/ird-02896657/file/s41467-017-02646-2.pdf

Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action

Autor: Denisa Baci, Giuliana Gremo, Valentina Barrera, Paolo Arese, Evelin Schwarzer, Oleksii A. Skorokhod

Publikováno v: Blood. 117(21)

Natural hemozoin (nHZ), prepared after schizogony, consists of crystalline ferriprotoporphyrin-IX dimers from undigested heme bound to host and parasite proteins and lipids. Phagocytosed nHZ alters important functions of host phagocytes. Most alterat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5bcb1a4912529e45c19f6f609690628
https://pubmed.ncbi.nlm.nih.gov/21460246