Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Giuliana, Biagi"'
QSAR study on a novel series of 8-azaadenine analogues proposed as A1 adenosine receptor antagonists
Autor:
Giuliana Biagi, Alessio Coi, Fatena Ahmad Nofal, Francesca Lidia Fiamingo, Ilaria Massarelli, Anna Maria Paola Bianucci, Michele Leonardi, Irene Giorgi, Daniele Pietra
Publikováno v:
European Journal of Medicinal Chemistry. 43:114-121
8-Azaadenines have been recently proposed as a novel promising class of adenosine A1 receptor antagonists. A QSAR study on 45 derivatives, synthesized in our laboratory as antagonists for A1 receptor, is described here. The use of the CODESSA program
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f7bd41f4cc8a4655bc1f296da8c780
https://doi.org/10.1016/j.ejmech.2007.02.009
https://doi.org/10.1016/j.ejmech.2007.02.009
Autor:
Giuliana Biagi, Federica Pacchini, Oreste LeRoy Salerni, Irene Giorgi, Valerio Scartoni, Oreste Livi
Publikováno v:
Journal of Heterocyclic Chemistry. 42:743-749
Title compounds were obtained starting from the key imidazole intermediate, 5-amino-1-phenyl-methyl-2-mercapto-1H-imidazole-4-carboxylic acid amide 5, readily derived from the base catalyzed rearrangement of a thiazole, 5-amino-2-phenylmethylaminothi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51bbfaa72e0beb50fe9be7a9ccd90da
https://doi.org/10.1002/jhet.5570420501
https://doi.org/10.1002/jhet.5570420501
Autor:
Oreste LeRoy Salerni, Giuliana Biagi, Federica Pacchini, Irene Giorgi, Valerio Scartoni, Oreste Livi
Publikováno v:
Journal of Heterocyclic Chemistry. 41:581-585
Title compounds bearing substituents on C(2), C(6) and C(8) were prepared from a newly synthesized pyrimidine derivative 11. The new pyrimidine 11 was generated from compound 2 through two different synthetic schemes. In one pathway, compound 2 was n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f75ca793d696a262df4bddc50f223e0
https://doi.org/10.1002/jhet.5570410416
https://doi.org/10.1002/jhet.5570410416
Autor:
Oreste Livi, Antonio Nardi, Enrica Martinotti, Irene Giorgi, Vincenzo Calderone, Giuliana Biagi, Alma Martelli
Publikováno v:
Il Farmaco. 59:397-404
As part of our program toward designing potassium channel openers, synthesis of a novel series of 1,5-diphenylsubstituted 1,2,3-triazoles, as potential activators of the large-conductance calcium-activated potassium channels (BK), as well as their va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f08e57286a4338fa9befc48fb084e1
https://doi.org/10.1016/j.farmac.2004.01.012
https://doi.org/10.1016/j.farmac.2004.01.012
Publikováno v:
Il Farmaco. 58:551-556
This paper reports synthesis and characterization, by spectroscopic methods, of three new N-methyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyrimidine isomers 3a, 3b and 3c. For comparison purpose the 3-benzyl-5-phenyl-7-chloro-1,2,3-triazolo[4,5-d]pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940865b2205e2b3c380213fea7dc4ba4
https://doi.org/10.1016/s0014-827x(03)00095-8
https://doi.org/10.1016/s0014-827x(03)00095-8
Publikováno v:
Journal of Heterocyclic Chemistry. 39:885-888
The 7-chloro-3-(2-chlorobenzyl)- and 7-chloro-3-(2-fluorobenzyl)-1,2,3-triazolo[4,5-d]pyrimidines (1 and 4), by nucleophilic replacement with some hydrazides, gave the corresponding 7-hydrazidoderivatives (2a-e and 5a-e). These, by heating in Dowther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07cedbfaa3a68d4a02b494e0e9fdc9ec
https://doi.org/10.1002/jhet.5570390505
https://doi.org/10.1002/jhet.5570390505
Autor:
Oreste Livi, Fabio Ciambrone, Giuliana Biagi, Pier Luigi Barili, Irene Giorgi, Valerio Scartoni
Publikováno v:
Journal of Heterocyclic Chemistry. 39:889-893
New tricyclic 1,2,3-triazolo-1,2,4-triazolo-pyridazine derivatives, bearing a methyl substituent on the 1,2,3-triazole ring, were prepared as potential biological agents. N-Methylation of dimethyl 1,2,3-triazole-4,5-dicarboxylate allowed synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7cd962bc415d6d9d257b0e13eee07f
https://doi.org/10.1002/jhet.5570390506
https://doi.org/10.1002/jhet.5570390506
Autor:
Giuliana Biagi, Enrica Martinotti, Vincenzo Calderone, Pier Luigi Barili, Irene Giorgi, Valerio Scartoni, Oreste Livi
Publikováno v:
Scopus-Elsevier
This paper reports the synthesis of a series of new 5-substituted-1-(2-hydroxybenzoyl)-benzotriazoles, which have been tested for their activity as possible activators of potassium channels. In rat aortic rings, the 'opened' derivatives 1a-f, interme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44924774e6ee2b7c90903cf43df6e13e
https://doi.org/10.1016/s0014-827x(01)01146-6
https://doi.org/10.1016/s0014-827x(01)01146-6
Autor:
Giuliana Biagi, Clementina Manera, Gino Giannaccini, Antonio Lucacchini, Irene Giorgi, Oreste Livi, Valerio Scartoni, Laura Betti
Publikováno v:
Il Farmaco. 54:615-623
Starting from the appropriate azides (4-chlorobenzyl-, 2-thiophenemethyl-, 2-fluorobenzyl-, and 4-fluorobenzylazides) agreeing with the substituent determining four series of derivatives ( a–d ), some 4-amino-substituted 1,2,3-triazolo[4,5-d]pyrida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b90f541098ed7de7a10a8a039be829
https://doi.org/10.1016/s0014-827x(99)00072-5
https://doi.org/10.1016/s0014-827x(99)00072-5
Autor:
Lucia Bertelli, Giuliana Biagi, Irene Giorgi, Clementina Manera, Oreste Livi, Valerio Scartoni, Laura Betti, Gino Giannaccini, Letizia Trincavelli, Pier Luigi Barili
Publikováno v:
European Journal of Medicinal Chemistry. 33:113-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bec20f0fad067a6396fcc258b6c61c
https://doi.org/10.1016/s0223-5234(98)80036-6
https://doi.org/10.1016/s0223-5234(98)80036-6