Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Giulia Vignaroli"'
Autor:
Adriano Angelucci, Maurizio Botta, Silvia Schenone, Flora Vitale, Claudia Mattei, Giovanni Luca Gravina, Ernesto Di Cesare, Claudio Festuccia, Federica Coniglio, Claudio Zamperini, Giulia Vignaroli, Alessia Calgani
Supplementary table s1 + supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f13a87275688ceb25a223e25bb651d9
https://doi.org/10.1158/1535-7163.22508364
https://doi.org/10.1158/1535-7163.22508364
Autor:
Giulia Vignaroli, Giulia Iovenitti, Arianna Mancini, Elena Dreassi, Adriano Angelucci, Maurizio Botta, Monia Chebbi, Silvia Schenone, Alessio Molinari, Francesco Orofino, Maura Caruana, Enrico Rango, Giovanni Luca Gravina
Publikováno v:
ACS Med Chem Lett
[Image: see text] Gold-nanoparticle (AuNP)-conjugated drugs represent a promising and innovative antitumor therapeutic approach. In our study, we describe the design, the synthesis, the preparation, and the characterization of AuNPs conjugated with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25cc5fb81adfcd90acb6d0841042ce0
http://hdl.handle.net/11365/1105986
http://hdl.handle.net/11365/1105986
Autor:
Ilaria Laurenzana, Mattia Mori, Daniela Vullo, Claudiu T. Supuran, Ylenia Cau, Giulia Vignaroli, Antonella Caivano, Maurizio Botta
Publikováno v:
ACS Chemical Biology. 10:1964-1969
In silico target fishing is an emerging tool in drug discovery, which is mostly used for primary target or off-target prediction and drug repositioning. In this work, we developed an in silico target fishing protocol to identify the primary target of
Autor:
Francesca Musumeci, Pierpaolo Calandro, Anna Lucia Fallacara, Giulia Vignaroli, David Colecchia, Andrea Sartucci, Alessio Molinari, Mario Chiariello, Adriano Angelucci, Silvia Schenone, Maurizio Botta, Giulia Iovenitti, Claudio Zamperini, Massimo Valoti, Elena Dreassi, Andrea Mancini, Federica Coniglio, Claudio Festuccia, Alessia Calgani
Publikováno v:
Journal of medicinal chemistry. 60(14)
Pyrazolo[3,4-d]pyrimidines are potent protein kinase inhibitors with promising antitumor activity but suboptimal aqueous solubility, consequently worth being further optimized. Herein, we present the one-pot two-step procedure for the synthesis of a
Autor:
Martina Mencarelli, Miroslava Kissova, Silvia Schenone, Giovanni Maga, Maurizio Botta, Marco Radi, Giulia Vignaroli, Deborah Sementa, Emmanuele Crespan
Publikováno v:
ACS Combinatorial Science. 16:168-175
A library of pyrazolo[3,4-d]pyrimidines, endowed with a high level of molecular diversity, has been developed applying a synthetic sequence that allowed C3, N1, C4, and C6 substitution. The enzymatic screening of this "privileged scaffold"-based comp
Autor:
Maurizio Botta, Miroslava Kissova, Francesca Musumeci, Marco Radi, Emmanuele Crespan, Giovanni Maga, Claudio Zamperini, Patrizia Sanità, Elena Dreassi, Silvia Schenone, Adriano Angelucci, Giulia Vignaroli
Publikováno v:
ACS Medicinal Chemistry Letters. 4:622-626
Design and synthesis of prodrugs of promising drug candidates represents a valid strategy to overcome the lack of favorable ADME properties, in particular aqueous solubility and bioavailability. We report herein the successful application of this str
Autor:
Elena Dreassi, Pierpaolo Calandro, Giulia Vignaroli, David Colecchia, Matteo Tavanti, Maurizio Botta, Claudio Zamperini, Federica Coniglio, Silvia Schenone, Mario Chiariello, Giulia Iovenitti, Massimo Valoti
Publikováno v:
Scientific Reports
Pyrazolo[3,4-d]pyrimidines are a class of compounds with a good activity against several cancer cell lines. Despite the promising anticancer activity, these molecules showed a poor aqueous solubility. This issue could threat the future development of
Suppression of SRC signaling is effective in reducing synergy between glioblastoma and stromal cells
Autor:
Maurizio Botta, Adriano Angelucci, Giovanni Luca Gravina, Giulia Vignaroli, Claudio Festuccia, Alessia Calgani, Flora Vitale, Ernesto Di Cesare, Silvia Schenone, Federica Coniglio, Claudia Mattei, Claudio Zamperini
Glioblastoma cells efficiently interact with and infiltrate the surrounding normal tissue, rendering surgical resection and adjuvant chemo/radiotherapy ineffective. New therapeutic targets, able to interfere with glioblastoma's capacity to synergize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0a6c3cd9ba80b24074a61360168cda
http://hdl.handle.net/11365/995715
http://hdl.handle.net/11365/995715
Autor:
Giulia Vignaroli, Pierpaolo Calandro, Ylenia Cau, Lucia Dello Iacono, Daniela Valensin, Mario Chiariello, Mattia Mori, Maurizio Botta
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(3)
BV02 is a reference inhibitor of 14-3-3 protein-protein interactions, which is currently used as chemical biology tool to understand the role of 14-3-3 proteins in pathological contexts. Due to chemical instability in certain conditions, its bioactiv
Autor:
Giulia Vignaroli, Encarna Gonzalo, Zeger Debyser, Silvio Massa, Cristina Tintori, Maurizio Botta, José A. Esté, Frauke Christ, Marta Rinaldi, Anna Innitzer, Luigi Franchi
Publikováno v:
ChemMedChem; Vol 6
ChemMedChem
ChemMedChem
As a continuation of our previous work, which resulted in the identification of a new hit compound as an HIV-1 integrase inhibitor, three novel series of salicylic acid derivatives were synthesized using three versatile and practical synthetic strate