Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy

Autor: Attilio Iemolo, Maria De Risi, Nadia Giordano, Giulia Torromino, Cristina Somma, Diletta Cavezza, Martina Colucci, Maria Mancini, Antonio de Iure, Rocco Granata, Barbara Picconi, Paolo Calabresi, Elvira De Leonibus

Publikováno v: npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-15 (2023)

Abstract Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson’s disease. α-synucleinopathy in the hippocampus and cortex is considered as the major risk factor. However, little is known a

Externí odkaz: https://doaj.org/article/3a072074db974ec284798fdb73dbfbf3

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Autor: Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of he

Externí odkaz: https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e3

Flexible use of allocentric and egocentric spatial memories activates differential neural networks in mice

Autor: Giulia Torromino, Elvira De Leonibus, Elisa Minicocci, Arianna Rinaldi, Andrea Mele, Alberto Oliverio, Rosa María López-Pedrajas, Elisa De Sanctis, Alessandra Cifra

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)

Este artículo se encuentra disponible en la siguiente URL: https://www.nature.com/articles/s41598-020-68025-y.pdf En este artículo también participan: Alberto Oliverio y Andrea Mele. Goal-directed navigation can be based on world-centered (allocen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c06c577b7931bed64388ada53f6c798
http://link.springer.com/article/10.1038/s41598-020-68025-y

On the role of the artist and the prejudice against AI-generated artworks

Autor: Dionigi Mattia Gagliardi, Giulia Torromino, Salvatore Gaetano Chiarella, Manuel Focareta, Sara Cuono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::c19883fabd9cc11b581b24ccb0dcd601
https://hdl.handle.net/11588/921047

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Autor: Yaakov Tuchman, Michele Tufano, Filomena Grazia Alvino, Alberto Salleo, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Maria Grazia Ferraro, Maria De Risi, Elvira De Leonibus, Alessandro Fraldi, Andrea Ballabio, Dulce Papy-Garcia, Lea Tunisi, Claudia Lubrano, Francesca Santoro, Salvatore Pulcrano, Gian Carlo Bellenchi, Elena Marrocco, Luigia Cristino

Publikováno v: Nature communications 12 (2021). doi:10.1038/s41467-021-23903-5
info:cnr-pdr/source/autori:De Risi M.; Tufano M.; Alvino F.G.; Ferraro M.G.; Torromino G.; Gigante Y.; Monfregola J.; Marrocco E.; Pulcrano S.; Tunisi L.; Lubrano C.; Papy-Garcia D.; Tuchman Y.; Salleo A.; Santoro F.; Bellenchi G.C.; Cristino L.; Ballabio A.; Fraldi A.; De Leonibus E./titolo:Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders/doi:10.1038%2Fs41467-021-23903-5/rivista:Nature communications/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Lysosomal storage disorders characterized by altered metabolism of heparan sulfate, including Mucopolysaccharidosis (MPS) III and MPS-II, exhibit lysosomal dysfunctions leading to neurodegeneration and dementia in children. In lysosomal storage disor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c87bc7247dabaa4f4bdf6a666e2442
https://doi.org/10.1038/s41467-021-23903-5