Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Giulia Saredi"'
Autor:
Vikram Tejwani, Thomas Carroll, Thomas Macartney, Susanne Bandau, Constance Alabert, Giulia Saredi, Rachel Toth, John Rouse
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a pr
Externí odkaz:
https://doaj.org/article/78e1855099f841b080867cac0d25d57d
Autor:
Giulia Saredi, Francesco N. Carelli, Giulia Furlan, Stephane Rolland, Sandra Piquet, Alex Appert, Luis Sanchez-Pulido, Jonathan L. Price, Pablo Alcon, Lisa Lampersberger, Anne-Cécile Déclais, Navin B. Ramakrishna, Rachel Toth, Chris P. Ponting, Sophie E. Polo, Eric A. Miska, Julie Ahringer, Anton Gartner, John Rouse
Histone chaperones control nucleosome density and chromatin structure. In yeast, the H3-H4 chaperone Spt2 controls histone deposition at active genes but its roles in metazoan chromatin structure and organismal physiology are not known. Here we ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c1bfb2b24c0e5d327e0cac806575e2f
https://doi.org/10.1101/2023.02.16.528451
https://doi.org/10.1101/2023.02.16.528451
Autor:
Till Bartke, Benjamin M. Foster, Jordan R. Becker, Kyosuke Nakamura, Thomas M. Frimurer, Laura C. Cesa, N V Nguyen, Chapman, Saulius Lukauskas, Tracey E. Beyer, Anja Groth, Giulia Saredi, Peter Faull
Publikováno v:
Nature cell biology
Nature Cell Biology
Nature Cell Biology
Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining1. HR supresses tumorigenesis1, but is restricted to the S and G2 phases of the cell cycle when a sister chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c85cb9867d76ea20af37a52561ce69
http://europepmc.org/articles/PMC6420097
http://europepmc.org/articles/PMC6420097
Autor:
Giulia Saredi, Till Bartke, Petr Cejka, Niels Mailand, Benjamin M. Foster, Dinshaw J. Patel, Colin Hammond, Constance Alabert, Ignasi Forné, Hongda Huang, Simon Bekker-Jensen, Nazaret Reverón-Gómez, Lucie J Mlejnkova, Anja Groth, Axel Imhof
Publikováno v:
Europe PubMed Central
Nature
Scopus-Elsevier
Nature
Scopus-Elsevier
After DNA replication, chromosomal processes including DNA repair and transcription take place in the context of sister chromatids. While cell cycle regulation can guide these processes globally, mechanisms to distinguish pre- and post-replicative st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa886626abb36983fbd15f1e03a694a8
https://doi.org/10.1038/nature18312
https://doi.org/10.1038/nature18312
Autor:
John Rouse, Giulia Saredi
Publikováno v:
Genes & Development. 33:1293-1294
Homologous recombination (HR) is an important route for repairing DNA double-strand breaks (DSBs). The early stages of HR are well understood, but later stages remain mysterious. In this issue of Genes & Development, Hustedt and colleagues (pp. 1397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8fff771442f6fa4e646ce1bde9dc458
https://doi.org/10.1101/gad.331850.119
https://doi.org/10.1101/gad.331850.119
Autor:
Giulia Saredi, Anne Strandsby, Martina Hödl, Cristina González-Aguilera, Caroline B Strømme, Hongda Huang, Shoudeng Chen, Anja Groth, Dinshaw J. Patel
During DNA replication, chromatin is reassembled by recycling of modified old histones and deposition of new ones. How histone dynamics integrates with DNA replication to maintain genome and epigenome information remains unclear. Here, we reveal how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d68f1bd851be58218c320f4fad9e143
https://europepmc.org/articles/PMC4685956/
https://europepmc.org/articles/PMC4685956/
Autor:
Marina Villamor-Payà, Sandra Segura-Bayona, Giulia Saredi, Matthew A.M. Todd, Sung Bau Lee, Camille Stephan-Otto Attolini, Ting Yu Chang, Anja Groth, Travis H. Stracker
Publikováno v:
Lee, S-B, Segura-Bayona, S, Villamor-Payà, M, Saredi, G, Todd, M A M, Attolini, C S-O, Chang, T-Y, Stracker, T H & Groth, A 2018, ' Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors ', Science Advances, vol. 4, no. 8, eaat4985, pp. 1-14 . https://doi.org/10.1126/sciadv.aat4985
Science Advances
Science Advances
TLKs promote nucleosome assembly and prevent fork collapse and DNA damage upon checkpoint or PARP inhibition.
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during ce
DNA sequence and epigenetic information embedded in chromatin must be faithfully duplicated and transmitted to daughter cells during ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a363996a5c6d0736bd92aae633d5b852