Výsledky vyhledávání - "Giulia Rotondi"

Akademický článek

Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience

Autor: Eugenia Resmini, Emanuela Zarra, Silvia Dotti, Giulia Rotondi, Angelo Vincenzo Cornaghi, Sara Madaschi, Elena Cimino, Giulia Massari, Letizia Chiara Pezzaioli, Caterina Buoso, Marco Sandri, Angela Girelli

Publikováno v: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-10 (2024)

Abstract Background Advanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact on Glycemia Risk Index (GRI) and other continuous glucose monitoring (CGM) metrics when swit

Externí odkaz: https://doaj.org/article/0c81c2e43f6b4e02b47164e994afb74b

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Akademický článek

Effect of Bifidobacterium bifidum Supplementation in Newborns Born from Cesarean Section on Atopy, Respiratory Tract Infections, and Dyspeptic Syndromes: A Multicenter, Randomized, and Controlled Clinical Trial

Autor: Anna Rita Bellomo, Giulia Rotondi, Prudenza Rago, Silvia Bloise, Luigi Di Ruzza, Annamaria Zingoni, Susanna Di Valerio, Eliana Valzano, Francesco Di Pierro, Massimiliano Cazzaniga, Alexander Bertuccioli, Luigina Guasti, Nicola Zerbinati, Riccardo Lubrano

Publikováno v: Microorganisms, Vol 12, Iss 6, p 1093 (2024)

Cesarean section is considered a possible trigger of atopy and gut dysbiosis in newborns. Bifidobacteria, and specifically B. bifidum, are thought to play a central role in reducing the risk of atopy and in favoring gut eubiosis in children. Nonethel

Externí odkaz: https://doaj.org/article/7faeba721295407581b5bd6e13754d87

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Akademický článek

Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

Autor: Paolo Guglielmi, Giulia Rotondi, Daniela Secci, Andrea Angeli, Paola Chimenti, Alessio Nocentini, Alessandro Bonardi, Paola Gratteri, Simone Carradori, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)

A large library of saccharin and acesulfame derivatives has been synthesised and evaluated against four isoforms of human carbonic anhydrase, the two off-targets hCA I/II and the tumour related isoforms hCA IX/XII. Different strategies of scaffold mo

Externí odkaz: https://doaj.org/article/78a54a75d73d42d58de2a564f1317cc7

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Akademický článek

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity

Autor: Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1511-1525 (2019)

A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPA

Externí odkaz: https://doaj.org/article/7280406604314cb88e2b4f9137207ce4

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Akademický článek

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

Autor: Giulia Rotondi, Paolo Guglielmi, Simone Carradori, Daniela Secci, Celeste De Monte, Barbara De Filippis, Cristina Maccallini, Rosa Amoroso, Roberto Cirilli, Atilla Akdemir, Andrea Angeli, Claudiu T. Supuran

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1400-1413 (2019)

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration

Externí odkaz: https://doaj.org/article/0d950a7741db47cf897a69d1aff65d30

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Akademický článek

Design, Synthesis, Docking Studies and Monoamine Oxidase Inhibition of a Small Library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles

Autor: Paolo Guglielmi, Simone Carradori, Giulio Poli, Daniela Secci, Roberto Cirilli, Giulia Rotondi, Paola Chimenti, Anél Petzer, Jacobus P. Petzer

Publikováno v: Molecules, Vol 24, Iss 3, p 484 (2019)

New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral compounds were separated into their

Externí odkaz: https://doaj.org/article/4454e3dbe88d4979a5ac2e720f57987b

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Natural compounds and extracts as novel antimicrobial agents

Autor: Virginia Pontecorvi, Giulia Rotondi, Paolo Guglielmi

Publikováno v: Expert Opinion on Therapeutic Patents. 30:949-962

Introduction: Antimicrobial resistance is a worldwide problem accounting for the reduction or in some cases absence of drugs effectiveness normally used in infections treatment. In the light of the even more spread ability of microbials to develop re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b08f2ae377f43978672817343d81cb8
https://doi.org/10.1080/13543776.2020.1853101

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Discovery, affinity maturation and multimerization of small molecule ligands against human tyrosinase and tyrosinase-related protein 1

Autor: Marco Catalano, Lyna Khettabi, Montserrat Soler-López, Gabriele Bassi, Maria Dichiara, Patrizia Murer, Dario Neri, Jörg Scheuermann, Giulia Rotondi

Publikováno v: RSC Medicinal Chemistry
RSC Medicinal Chemistry, 12 (3)
'RSC Medicinal Chemistry ', vol: 12, pages: 363-369 (2021)

Human tyrosinase (hTYR) and tyrosinase-related protein 1 (hTYRP1) are closely-related enzymes involved in the synthesis of melanin, which are selectively expressed in melanocytes and, in a pathological context, in melanoma lesions. We used a previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cacf2fa48c4cf8c0cacb44e745c211
https://pubmed.ncbi.nlm.nih.gov/34041485

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Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation

Autor: Andrea Angeli, Paolo Guglielmi, Simone Carradori, Giulia Rotondi, Alessandro Bonardi, Claudiu T. Supuran, Daniela Secci, Paola Chimenti, Alessio Nocentini, Paola Gratteri

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1891-1905 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a001d37adbf8a48d224036a97a66be
http://hdl.handle.net/11573/1449256

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Benzo[

Autor: Paolo, Guglielmi, Daniela, Secci, Anél, Petzer, Donatella, Bagetta, Paola, Chimenti, Giulia, Rotondi, Claudio, Ferrante, Lucia, Recinella, Sheila, Leone, Stefano, Alcaro, Gokhan, Zengin, Jacobus P, Petzer, Francesco, Ortuso, Simone, Carradori

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d3c53a5e01f287409542abeb2a0184e
https://pubmed.ncbi.nlm.nih.gov/31422706

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