Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Giulia Rossetti"'
Autor:
Can Bora Yildiz, Tathagata Kundu, Julia Gehrmann, Jannis Koesling, Amin Ravaei, Philip Wolff, Florian Kraft, Tiago Maié, Mira Jakovcevski, Daniel Pensold, Olav Zimmermann, Giulia Rossetti, Ivan G. Costa, Geraldine Zimmer-Bensch
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-19 (2023)
Abstract Cell–cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestrating cell migration during development and in diverse cancer types. Epigenetic mechanisms are key for integrating external
Externí odkaz:
https://doaj.org/article/243a1b4e0c1c4caf93c65b9f83fff63e
Autor:
Pascal D. Vos, Giulia Rossetti, Jessica L. Mantegna, Stefan J. Siira, Andrianto P. Gandadireja, Mitchell Bruce, Samuel A. Raven, Olga Khersonsky, Sarel J. Fleishman, Aleksandra Filipovska, Oliver Rackham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The ability to alter the genomes of living cells is key to understanding how genes influence the functions of organisms and will be critical to modify living systems for useful purposes. Here, the authors use computational design to discover Cas9 enz
Externí odkaz:
https://doaj.org/article/42738fae0b8a437eab42e9af9c83d4ca
Autor:
Henri-Baptiste Marjault, Ola Karmi, Ke Zuo, Dorit Michaeli, Yael Eisenberg-Domovich, Giulia Rossetti, Benoit de Chassey, Jacky Vonderscher, Ioav Cabantchik, Paolo Carloni, Ron Mittler, Oded Livnah, Eric Meldrum, Rachel Nechushtai
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)
Marjault et al. report two crystal structures of a drug molecule bound to NEET proteins mNT and NAF-1 and the effects of this molecule on diabetic mice, suggesting an approach for reducing mitochondrial iron and ROS levels in diabetic patients.
Externí odkaz:
https://doaj.org/article/5fdc9f8e63f74c36ac4f3fdb8fd0831a
Autor:
Michael A Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E.M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino-Hernandez, Mirko Wagner, Thomas Carell, N. Jon Shah, Jörg B. Schulz, Dierk Niessing, Aaron Voigt, Giulia Rossetti
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 443-458 (2022)
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxici
Externí odkaz:
https://doaj.org/article/b64bb5ae313246c5aac74fe4b11f4b6c
Publikováno v:
Biology, Vol 12, Iss 4, p 581 (2023)
The disordered nature of Intrinsically Disordered Proteins (IDPs) makes their structural ensembles particularly susceptible to changes in chemical environmental conditions, often leading to an alteration of their normal functions. A Radial Distributi
Externí odkaz:
https://doaj.org/article/4b8ba59bd96f40388c341abdd2d69c28
Autor:
Linh Gia Hoang, Jonas Goßen, Riccardo Capelli, Toan T. Nguyen, Zhaoxi Sun, Ke Zuo, Jörg B. Schulz, Giulia Rossetti, Paolo Carloni
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Human NEET proteins, such as NAF-1 and mitoNEET, are homodimeric, redox iron-sulfur proteins characterized by triple cysteine and one histidine-coordinated [2Fe-2S] cluster. They exist in an oxidized and reduced state. Abnormal release of the cluster
Externí odkaz:
https://doaj.org/article/20b46ca1eb1d4ec189b28405eab1c6f5
Autor:
Jannis Körner, Simone Albani, Vishal Sudha Bhagavath Eswaran, Anna B. Roehl, Giulia Rossetti, Angelika Lampert
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The long history of local anesthetics (LAs) starts out in the late 19th century when the content of coca plant leaves was discovered to alleviate pain. Soon after, cocaine was established and headed off to an infamous career as a substance causing ad
Externí odkaz:
https://doaj.org/article/5d41622628a04be09eaf85b48423b62a
Autor:
Lisbeth R. Kjølbye, Gilberto P. Pereira, Alessio Bartocci, Martina Pannuzzo, Simone Albani, Alessandro Marchetto, Brian Jiménez-García, Juliette Martin, Giulia Rossetti, Marco Cecchini, Sangwook Wu, Luca Monticelli, Paulo C. T. Souza
Publikováno v:
QRB Discovery, Vol 3 (2022)
Coarse-grained (CG) modelling with the Martini force field has come of age. By combining a variety of bead types and sizes with a new mapping approach, the newest version of the model is able to accurately simulate large biomolecular complexes at mil
Externí odkaz:
https://doaj.org/article/7aa32db6405a4bcaa6e367b8f437930f
Autor:
Nicola Ferreira, Christopher E Andoniou, Kara L Perks, Judith A Ermer, Danielle L Rudler, Giulia Rossetti, Ambika Periyakaruppiah, Jamie K Y Wong, Oliver Rackham, Peter G Noakes, Mariapia A Degli-Esposti, Aleksandra Filipovska
Publikováno v:
PLoS Genetics, Vol 16, Iss 3, p e1008604 (2020)
The influence of environmental insults on the onset and progression of mitochondrial diseases is unknown. To evaluate the effects of infection on mitochondrial disease we used a mouse model of Leigh Syndrome, where a missense mutation in the Taco1 ge
Externí odkaz:
https://doaj.org/article/4c2f6a2af5f1410aad89e487d9251e55
Autor:
Mareike Bütepage, Christian Preisinger, Alexander von Kriegsheim, Anja Scheufen, Eva Lausberg, Jinyu Li, Ferdinand Kappes, Regina Feederle, Sabrina Ernst, Laura Eckei, Sarah Krieg, Gerhard Müller-Newen, Giulia Rossetti, Karla L. H. Feijs, Patricia Verheugd, Bernhard Lüscher
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Abstract Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells. ARTDs transfer either single or multiple
Externí odkaz:
https://doaj.org/article/827b3706279b44c7a5d83f1b4485f73c