Genetic plasticity of the Shigella virulence plasmid is mediated by intra- and inter-molecular events between insertion sequences.

Autor: Giulia Pilla, Gareth McVicker, Christoph M Tang

Publikováno v: PLoS Genetics, Vol 13, Iss 9, p e1007014 (2017)

Acquisition of a single copy, large virulence plasmid, pINV, led to the emergence of Shigella spp. from Escherichia coli. The plasmid encodes a Type III secretion system (T3SS) on a 30 kb pathogenicity island (PAI), and is maintained in a bacterial p

Externí odkaz: https://doaj.org/article/c4a9d84a85da492db516ee445001d33b

Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems

Autor: Jessica E. Martyn, Giulia Pilla, Sarah Hollingshead, Kristoffer S. Winther, Susan Lea, Gareth McVicker, Christoph M. Tang

Publikováno v: Martyn, J E, Pilla, G, Hollingshead, S, Winther, K S, Lea, S, McVicker, G & Tang, C M 2022, ' Maintenance of the Shigella sonnei Virulence Plasmid Is Dependent on Its Repertoire and Amino Acid Sequence of Toxin-Antitoxin Systems ', Journal of Bacteriology, vol. 204, no. 3, e00519-21 . https://doi.org/10.1128/jb.00519-21

Shigella sonnei is a major cause of bacillary dysentery and an increasing concern due to the spread of multidrug resistance. S. sonnei harbors pINV, an;210 kb plasmid that encodes a type III secretion system (T3SS), which is essential for virulence.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca31c727fd7bcbff7408775ecdbd77f8
https://pubmed.ncbi.nlm.nih.gov/34978459

The role of toxin:antitoxin systems and insertion sequences in the loss of virulence in Shigella sonnei

Autor: Gareth McVicker, Susan M. Lea, Christoph M. Tang, Sarah Hollingshead, Mariya Lobanovska, Jessica E. Martyn, Kristoffer Skovbo Winther, Giulia Pilla

SUMMARYThe Shigella plasmid, pINV, contains a 30 kb pathogenicity island (PAI) encoding a Type III secretion system (T3SS) which is essential for virulence. During growth in the laboratory, avirulent colonies of Shigella (which do not express a T3SS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::480fc4df3e7bd0e991d315941134e169
https://doi.org/10.1101/2020.08.10.243006

Going around in circles: virulence plasmids in enteric pathogens

Autor: Giulia Pilla, Christoph M. Tang

Publikováno v: Nature Reviews Microbiology. 16(8)

Plasmids have a major role in the development of disease caused by enteric bacterial pathogens. Virulence plasmids are usually large (>40 kb) low copy elements and encode genes that promote host–pathogen interactions. Although virulence plasmids pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57af681ac39e1abaac0d6287598121cc
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