Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Giulia Pavani"'
Autor:
Clyde A. Campbell, Rodolfo Calderon, Giulia Pavani, Xiaoyi Cheng, Radwa Barakat, Elizabeth Snella, Fang Liu, Xiyu Peng, Jeffrey J. Essner, Karin S. Dorman, Maura McGrail, Paul Gadue, Deborah L. French, Raquel Espin-Palazon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal control. However, cell signaling relies on limited transcriptional effectors, having to be re-used temporally and
Externí odkaz:
https://doaj.org/article/3dcd259cad5344e190f688aa08345ae0
Autor:
Xiaoyi Cheng, Radwa Barakat, Giulia Pavani, Masuma Khatun Usha, Rodolfo Calderon, Elizabeth Snella, Abigail Gorden, Yudi Zhang, Paul Gadue, Deborah L. French, Karin S. Dorman, Antonella Fidanza, Clyde A. Campbell, Raquel Espin-Palazon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, genera
Externí odkaz:
https://doaj.org/article/c2136f3074024e3ca14b63136730c55e
Publikováno v:
Cells, Vol 13, Iss 10, p 800 (2024)
In recent years, clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) protein have emerged as a revolutionary gene editing tool to treat inherited disorders affecting different organ systems, such as blood a
Externí odkaz:
https://doaj.org/article/6317b1de847948b1bf4bd16131e5c54e
Autor:
Giulia Pavani, Marine Laurent, Anna Fabiano, Erika Cantelli, Aboud Sakkal, Guillaume Corre, Peter J. Lenting, Jean-Paul Concordet, Magali Toueille, Annarita Miccio, Mario Amendola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
A platform for systemic therapeutic transgene expression independent of patient mutations needs a safe and highly transcribed locus. Here the authors ex vivo edit HPSCs using CRISPR-Cas9 to integrate transgenes under the α-globin promoter to achieve
Externí odkaz:
https://doaj.org/article/bd6f18164a234100805135163a84adaa
Autor:
Giulia Pavani, Mario Amendola
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Externí odkaz:
https://doaj.org/article/fb30109d9c404c83b3c5eead226f6db9
Autor:
Giulia Pavani, Mario Amendola
Publikováno v:
Frontiers in Genome Editing, Vol 2 (2021)
Genome-editing technologies have the potential to correct most genetic defects involved in blood disorders. In contrast to mutation-specific editing, targeted gene insertion can correct most of the mutations affecting the same gene with a single ther
Externí odkaz:
https://doaj.org/article/9ff9641614d140b799c9625b896e6c49
Autor:
Giulia Pavani, Marine Laurent, Anna Fabiano, Erika Cantelli, Aboud Sakkal, Guillaume Corre, Peter J. Lenting, Jean-Paul Concordet, Magali Toueille, Annarita Miccio, Mario Amendola
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/898e5e098064488393056ba2d4b030b3
Autor:
Hyun Hyung An, Alyssa L. Gagne, Jean Ann Maguire, Giulia Pavani, Osheiza Abdulmalik, Paul Gadue, Deborah L. French, Connie M. Westhoff, Stella T. Chou
Publikováno v:
Blood. 140(15)
Red blood cell (RBC) transfusion is one of the most common medical treatments, with more than 10 million units transfused per year in the United States alone. Alloimmunization to foreign Rh proteins (RhD and RhCE) on donor RBCs remains a challenge fo
Publikováno v:
Curr Opin Hematol
Purpose of review Megakaryocytes are rare hematopoietic cells that play an instrumental role in hemostasis, and other important biological processes such as immunity and wound healing. With the advent of cell reprogramming technologies and advances i
Autor:
Michael W. Drazer, Joshua G. Klein, Mortimer Poncz, Catriana C. Nations, Lucy A. Godley, Giulia Pavani, Deborah L. French, Rodney M. Camire, Jean Ann Maguire, Paul Gadue, Sara Borst
Publikováno v:
Stem Cell Reports
Summary Inherited thrombocytopenia results in low platelet counts and increased bleeding. Subsets of these patients have monoallelic germline mutations in ETV6 or RUNX1 and a heightened risk of developing hematologic malignancies. Utilizing CRISPR-Ca