Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties

Autor: Alice Sosic, Francesco Frecentese, Giulia Olivato, Daniele Rollo, Caterina Carraro, Elia Gamba, Vincenzo Santagada, Barbara Gatto

Publikováno v: Viruses, Vol 14, Iss 10, p 2133 (2022)

2,6-dipeptidyl-anthraquinones are polycyclic planar systems substituted at opposite ring positions by short aminoacyl side chains. Derivatives with positively charged terminal amino acids showed in vitro inhibition of HIV-1 nucleocapsid (NC) protein

Externí odkaz: https://doaj.org/article/b36a53a00cba473d94b124b80a9a30b3

In vitro Evaluation of Bis-3-chloropiperidines as RNA Modulators Targeting TAR and TAR-protein Interaction

Autor: Alice Sosic, Giulia Olivato, Caterina Carraro, Richard Göttlich, Dan Fabris, Barbara Gatto

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 582
International Journal of Molecular Sciences, Vol 23, Iss 582, p 582 (2022)
International Journal of Molecular Sciences

After a long limbo, RNA has gained its credibility as a druggable target, fully earning its de-served role in the next-generation area of pharmaceutical R&D. We have recently probed the Trans-Activation Response element (TAR), a RNA stem–bulge–lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c87eedd5129299856f43ae4d97b95c
https://doi.org/10.20944/preprints202112.0225.v1