Pharmacokinetics and pharmacogenomics of ribociclib in black patients with metastatic breast cancer the LEANORA study

Autor: Ilana Schlam, D. Max Smith, Cody Peer, Tristan Sissung, Keith T. Schmidt, Ming Tan, Ami Chitalia, Nanette H. Bishopric, Seth Steinberg, Hyoyoung Choo-Wosoba, Giulia Napoli, Christopher Gallagher, Nadia Ashai, Kristen Whitaker, Candace Mainor, Shruti Tiwari, Nicole Swanson, Stacy Malloy, Claudine Isaacs, William Douglas Figg, Sandra M. Swain

Publikováno v: npj Breast Cancer, Vol 10, Iss 1, Pp 1-9 (2024)

Abstract Underrepresented populations’ participation in clinical trials remains limited, and the potential impact of genomic variants on drug metabolism remains elusive. This study aimed to assess the pharmacokinetics (PK) and pharmacogenomics (PGx

Externí odkaz: https://doaj.org/article/ad6ed8bebf71498f80dbc2876ee15de4

Novel P2X7 Antagonist Ameliorates the Early Phase of ALS Disease and Decreases Inflammation and Autophagy in SOD1-G93A Mouse Model

Autor: Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Giulia Napoli, Mattia Freschi, Francesca Sironi, Paolo Pevarello, Paola Tarroni, Chiara Liberati, Caterina Bendotti, Cinzia Volonté

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 19, p 10649 (2021)

Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused by activated microglia and infiltrated immune cells. How to successfully balance neuroprotective versus neurotoxic actions through the use of anti-in

Externí odkaz: https://doaj.org/article/42310564a9ee4f7692924efaffaf27c7

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

Autor: Chiara Parisi, Giulia Napoli, Pablo Pelegrin, Cinzia Volonté

Publikováno v: Mediators of Inflammation, Vol 2016 (2016)

Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3–5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty g

Externí odkaz: https://doaj.org/article/2338f0c2a3cd43f181bb522927ee65df

Novel p2x7 antagonist ameliorates the early phase of als disease and decreases inflammation and autophagy in sod1-g93a mouse model

Autor: Francesca Sironi, Paolo Pevarello, Paola Fabbrizio, Paola Tarroni, Susanna Amadio, Chiara Liberati, Giulia Napoli, Cinzia Volonté, Caterina Bendotti, Savina Apolloni, Mattia Freschi

Publikováno v: International journal of molecular sciences
22 (2021): 10649. doi:10.3390/ijms221910649
info:cnr-pdr/source/autori:Apolloni S.; Fabbrizio P.; Amadio S.; Napoli G.; Freschi M.; Sironi F.; Pevarello P.; Tarroni P.; Liberati C.; Bendotti C.; Volonte C./titolo:Novel p2x7 antagonist ameliorates the early phase of als disease and decreases inflammation and autophagy in sod1-g93a mouse model/doi:10.3390%2Fijms221910649/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:10649/pagina_a:/intervallo_pagine:10649/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10649, p 10649 (2021)

Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory component caused by activated microglia and infiltrated immune cells. How to successfully balance neuroprotective versus neurotoxic actions through the use of anti-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0af5f900ac1d60769e9eb61edd5e8e5
http://www.scopus.com/record/display.url?eid=2-s2.0-85115989250&origin=inward

Heterozygous nonsense ARX mutation in a family highlights the complexity of clinical and molecular diagnosis in case of chromosomal and single gene disorder co‐inheritance

Autor: Agnese Giovannetti, Francesco Cardona, Maria Luce Genovesi, Enrica Marchionni, Viviana Caputo, Alice Traversa, Giulia Napoli, Lucia Manganaro, Katia Margiotti, Alessandro De Luca, Silvia Bernardo, Francesca Piceci Sparascio, Massimo Carella, Francesco Petrizzelli, Antonio Pizzuti, Tommaso Mazza, Noemi Panzironi

Publikováno v: Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine, Vol 8, Iss 8, Pp n/a-n/a (2020)

Background Corpus callosum agenesis (ACC) is one of the most frequent Central Nervous System (CNS) malformations. However, genetics underlying isolated forms is still poorly recognized. Here, we report on two female familial cases with partial ACC. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd80dd13e5b9d573d5cf7f5016730752
http://europepmc.org/articles/PMC7434725