Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Giulia Maria Piperno"'
Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors
Autor:
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings. However, the impact of cross-presenting cDC1 and the potential of DC-based therapies in
Externí odkaz:
https://doaj.org/article/f7c6a9ff87e544acbdd02715c577e12b
Autor:
Ambra Cappelletto, Edoardo Alfì, Nina Volf, Thi Van Anh Vu, Francesca Bortolotti, Giulio Ciucci, Simone Vodret, Marco Fantuz, Martina Perin, Andrea Colliva, Giacomo Rozzi, Matilde Rossi, Giulia Ruozi, Lorena Zentilin, Roman Vuerich, Daniele Borin, Romano Lapasin, Silvano Piazza, Mattia Chiesa, Daniela Lorizio, Luca Triboli, Sandeep Kumar, Gaia Morello, Claudio Tripodo, Maurizio Pinamonti, Giulia Maria Piperno, Federica Benvenuti, Alessandra Rustighi, Hanjoong Jo, Stefano Piccolo, Giannino Del Sal, Alessandro Carrer, Mauro Giacca, Serena Zacchigna
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-14 (2024)
Abstract Background New drugs to tackle the next pathway or mutation fueling cancer are constantly proposed, but 97% of them are doomed to fail in clinical trials, largely because they are identified by cellular or in silico screens that cannot predi
Externí odkaz:
https://doaj.org/article/a789156b8a0b44008d091dcfb970d332
Autor:
Sonal Joshi, Lucía López, Luciano Gastón Morosi, Roberto Amadio, Manendra Pachauri, Marco Bestagno, Ironya Paul Ogar, Mauro Giacca, Giulia Maria Piperno, Daan Vorselen, Federica Benvenuti
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114096- (2024)
Summary: Receptors controlling the cross-presentation of tumor antigens by macrophage subsets in cancer tissues are poorly explored. Here, we show that TIM4+ large peritoneal macrophages efficiently capture and cross-present tumor-associated antigens
Externí odkaz:
https://doaj.org/article/c2dde8a380ab4786a23705a24951b4bc
Autor:
Francesca Simoncello, Giulia Maria Piperno, Nicoletta Caronni, Roberto Amadio, Ambra Cappelletto, Giulia Canarutto, Silvano Piazza, Silvio Bicciato, Federica Benvenuti
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Lung tumor-infiltrating neutrophils are known to support growth and dissemination of cancer cells and to suppress T cell responses. However, the precise impact of tissue neutrophils on programming and differentiation of anticancer CD8 T cells in vivo
Externí odkaz:
https://doaj.org/article/3cc3832c6ebb4043a0769d160d0b66d7
Autor:
Nicoletta Caronni, Giulia Maria Piperno, Francesca Simoncello, Oriana Romano, Simone Vodret, Yuichi Yanagihashi, Regine Dress, Charles-Antoine Dutertre, Mattia Bugatti, Pierre Bourdeley, Annalisa Del Prete, Tiziana Schioppa, Emilia Maria Cristina Mazza, Licio Collavin, Serena Zacchigna, Renato Ostuni, Pierre Guermonprez, William Vermi, Florent Ginhoux, Silvio Bicciato, Shigekatzu Nagata, Federica Benvenuti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1). Here the authors show that the loss of TIM4 expression in lung tumor associated c
Externí odkaz:
https://doaj.org/article/ed313efe49174e4e8c4bd8e169965081
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Modified or misplaced DNA can be recognized as a danger signal by mammalian cells. Activation of cellular responses to DNA has evolved as a defense mechanism to microbial infections, cellular stress, and tissue damage, yet failure to control this mec
Externí odkaz:
https://doaj.org/article/a74de9bad5c4441bab50a851da907bf6
Autor:
Giulia Maria Piperno, Asma Naseem, Giulia Silvestrelli, Roberto Amadio, Nicoletta Caronni, Karla Evelia Cervantes-Luevano, Nalan Liv, Judith Klumperman, Andrea Colliva, Hashim Ali, Francesca Graziano, Philippe Benaroch, Hans Haecker, Richard N. Hanna, Federica Benvenuti
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
Dysregulated sensing of self–nucleic acid is a leading cause of autoimmunity in multifactorial and monogenic diseases. Mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of cytoskeletal dynamics in immune cells, cause autoimmune
Externí odkaz:
https://doaj.org/article/61132181a0f44b3abc254bbae0684a5e
Autor:
Alessandra Tesser, Giulia Maria Piperno, Alessia Pin, Elisa Piscianz, Valentina Boz, Federica Benvenuti, Alberto Tommasini
Publikováno v:
Cells, Vol 10, Iss 4, p 785 (2021)
Cytoplasmic nucleic acids sensing through cGAS-STING-TBK1 pathway is crucial for the production of antiviral interferons (IFNs). IFN production can also be induced by lipopolysaccharide (LPS) stimulation through Toll-like receptor 4 (TLR4) in appropr
Externí odkaz:
https://doaj.org/article/fd235f6027c240b2ad479814b547d2b7
Autor:
Lucia Lopez-Rodriguez, Pierre Bourdely, Federica La Terza, Giuseppe Rospo, Luciano Morosi, Roberto Amadio, Giulia Maria Piperno, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti
The efficacy of immune checkpoint blockade (ICB) in NSCLC depends on the tumor mutational burden (TMB). However, a fraction of patients with high TMB and predicted immunogenic neoantigens (neoAgs) do not respond. Here we show that in a model of highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b69461aa9cfa096a596e894578f8ec5
https://doi.org/10.21203/rs.3.rs-2752957/v1
https://doi.org/10.21203/rs.3.rs-2752957/v1
Autor:
Zahraa Alraies, Claudia A. Rivera, Maria-Graciela Delgado, Doriane Sanséau, Mathieu Maurin, Roberto Amadio, Giulia Maria Piperno, Garett Dunsmore, Aline Yatim, Livia Lacerda Mariano, Pablo J. Sáez, Matthieu Gratia, Olivier Lamiable, Aurélie Moreau, Alice Williart, Benoit Albaud, Patricia Legoix, Hideki Nakano, Donald N Cook, Toby Lawrence, Nicolas Manel, Federica Benvenuti, Florent Ginhoux, Hélène D. Moreau, Guilherme P.F. Nader, Matthieu Piel, Ana-Maria Lennon-Duménil
Motile cells such as immune and cancer cells experience large deformation events that result from the physical constraints they encounter while migrating within tissues or circulating between organs. It has become increasingly clear that these cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20cf5b23643b89dcf86e1b2b110cd02d
https://doi.org/10.1101/2022.08.09.503223
https://doi.org/10.1101/2022.08.09.503223