Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Giulia Lazzeroni"'
Autor:
Cesare Federico, Andrea Caricasole, Letizia Magnoni, Wolfgang Fecke, Valentina Porcari, Freddy Heitz, Giulia Lazzeroni, Salvatore La Rosa, Luisa Massai, Tiziana Benicchi, Lara Rossini, Daniela Diamanti
Publikováno v:
SLAS Discovery. 18:984-996
Huntington's Disease is a rare neurodegenerative disease caused by an abnormal expansion of CAG repeats encoding polyglutamine in the first exon of the huntingtin gene. N-terminal fragments containing polyglutamine (polyQ) sequences aggregate and can
Autor:
Nicola P. Caradonna, Giulia Lazzeroni, David C. Rubinsztein, Fiona M. Menzies, Alessia Tarditi, Venkata P. Satagopam, Valentina Porcari, Angeleen Fleming, Reinhard Schneider, Freddy Heitz, Chiara Caramelli, Birte Sönnichsen, Maria Jimenez-Sanchez, Carla Scali, Sara Imarisio, Michael Hannus, Giuseppe Pollio, Wun Lam, Daniela Diamanti, Catherine K. Xu, Eduardo Gonzalez-Couto, Arianna Nencini, Gian Luca Sardone, Andrea Caricasole, Cahir J. O'Kane, Matteo Andreini, Luisa Massai, Guido Marconi, Teresa Ed Dami
Publikováno v:
Nature chemical biology
Nature chemical biology, 11(5), 347–354. (2015).
Nature chemical biology, 11(5), 347–354. (2015).
Huntington’s disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified novel modifiers of mutant HTT toxicity by performing a large-scale “druggable g
Autor:
Vincenzo Miragliotta, Tiziana Benicchi, Pasquale Fiengo, Laura Bettinetti, Carla Scali, Salvatore La Rosa, Giulia Lazzeroni, Letizia Magnoni, Ruth Luthi-Carter, Ilaria Ceccarelli, Davide Franceschini, Freddy Heitz, Michela Valacchi, Cesare Federico, Ozgun Gokce, Enrica Diodato
Here, we describe the selection and optimization of a chemical series active in both a full-length and a fragment-based Huntington's disease (HD) assay. Twenty-four thousand small molecules were screened in a phenotypic HD assay, identifying a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe09811d008fffe6be5c325676705d19
https://infoscience.epfl.ch/record/191100
https://infoscience.epfl.ch/record/191100