The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth

Autor: Giulia L. M. Boezio, Shengnan Zhao, Josephine Gollin, Rashmi Priya, Shivani Mansingh, Stefan Guenther, Nana Fukuda, Felix Gunawan, Didier Y. R. Stainier

Publikováno v: Disease Models & Mechanisms, Vol 16, Iss 5 (2023)

Externí odkaz: https://doaj.org/article/a02704bb6d594c64a2a10199f6aedfe8

Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish

Autor: Pia R. Lundegaard, Janett Piesker, Clemens Mueller, Giulia L. M. Boezio, Didier Y.R. Stainier, Anabela Bensimon-Brito, Arno Nauerth, Christian S. M. Helker, Radhan Ramadass, Srinath Ramkumar, Astrid Wietelmann, João Cardeira-da-Silva

Publikováno v: Bensimon-Brito, A, Boezio, G L M, Cardeira-da-Silva, J, Wietelmann, A, Ramkumar, S, Lundegaard, P R, Helker, C S M, Ramadass, R, Piesker, J, Nauerth, A, Mueller, C & Stainier, D Y R 2022, ' Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish ', Cardiovascular Research, vol. 118, no. 12, pp. 2665–2687 . https://doi.org/10.1093/cvr/cvab310

Aims Mammalian models have been instrumental in investigating adult heart function and human disease. However, electrophysiological differences with human hearts and high costs motivate the need for non-mammalian models. The zebrafish is a well-estab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777608fd9b571bf7a88b7573b49754c3
https://curis.ku.dk/ws/files/358644811/cvab310.pdf

Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tract

Autor: Janett Piesker, Christian S. M. Helker, Stefan Guenther, Didier Y.R. Stainier, Giulia L. M. Boezio, Anabela Bensimon-Brito

Publikováno v: eLife
eLife, Vol 9 (2020)

The development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects in OFT development can lead to severe malformations, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bddcf0c6fe85c1747c6c1b268fd624
http://europepmc.org/articles/PMC7524555

Endothelial TGF-β signaling instructs smooth muscle development in the cardiac outflow tract

Autor: Didier Y.R. Stainier, Giulia L. M. Boezio, Anabela Bensimon-Brito, Janett Piesker, Stefan Guenther, Christian S. M. Helker

SummaryThe development of the cardiac outflow tract (OFT), which connects the heart to the great arteries, relies on a complex crosstalk between endothelial (ECs) and smooth muscle (SMCs) cells. Defects in OFT development can lead to severe malformat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9bf50534f2e8345553130cef8ed4f9

Cardiac valve regeneration in adult zebrafish: importance of TGFß signaling in new tissue formation

Autor: Héctor Sánchez-Iranzo, Anabela Bensimon-Brito, Dimitris Beis, Didier Y.R. Stainier, Soni Savai Pullamsetti, Carsten Kuenne, Janett Piesker, Dijana Iloska, Stefan Guenther, Srinath Ramkumar, Giulia L. M. Boezio, Nadia Mercader

SummaryCardiac valve disease can lead to severe cardiac dysfunction and is thus a frequent cause of morbidity and mortality. Its main treatment is valve replacement, which is currently greatly limited by the poor recellularization and tissue formatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537eb9ad9ffd5f174d91e7c4ceab0d72
https://doi.org/10.1101/697706