Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Giulia Hardouin"'
Autor:
Panagiotis Antoniou, Giulia Hardouin, Pierre Martinucci, Giacomo Frati, Tristan Felix, Anne Chalumeau, Letizia Fontana, Jeanne Martin, Cecile Masson, Megane Brusson, Giulia Maule, Marion Rosello, Carine Giovannangeli, Vincent Abramowski, Jean-Pierre de Villartay, Jean-Paul Concordet, Filippo Del Bene, Wassim El Nemer, Mario Amendola, Marina Cavazzana, Anna Cereseto, Oriana Romano, Annarita Miccio
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Antoniou and colleagues used base editing to generate a variety of mutations inducing γ-globin and rescue the β-hemoglobinopathy phenotype. This strategy was safe and effective in long-term repopulating hematopoietic stem/progenitor cells.
Externí odkaz:
https://doaj.org/article/313aa0fc4a794f6798f4ea808d498494
Autor:
Giulia Hardouin, Panagiotis Antoniou, Pierre Martinucci, Tristan Felix, Marta Zoccheddu, Anne Chalumeau, Giacomo Frati, Sandra Manceau, Laure Joseph, Oriana Romano, Marina Cavazzana, Annarita Miccio
Publikováno v:
Blood. 140:7778-7779
Autor:
Panagiotis Antoniou, Mathieu von Joest, Letizia Fontana, Giulia Hardouin, Pierre Martinucci, Marina Cavazzana, Annarita Miccio
Publikováno v:
Blood. 140:7788-7789
Autor:
Giulia Hardouin, Panagiotis Antoniou, Pierre Martinucci, Tristan Felix, Sandra Manceau, Laure Joseph, Cécile Masson, Samantha Scaramuzza, Giuliana Ferrari, Marina Cavazzana, Annarita Miccio
Publikováno v:
Blood
β-Thalassemia (BT) is one of the most common genetic diseases worldwide and is caused by mutations affecting β-globin production. The only curative treatment is allogenic hematopoietic stem/progenitor cells (HSPCs) transplantation, an approach limi
Autor:
Benjamin Granger, Mathieu Vautier, Yves Allenbach, Harmen Reyngoudt, Pierre G. Carlier, Nicolas Champtiaux, Baptiste Hervier, Cedi Koumako, Olivier Benveniste, Jean-Marc Boisserie, Perrine Guillaume-Jugnot, Océane Landon-Cardinal, Aude Rigolet, Giulia Hardouin
Publikováno v:
Seminars in Arthritis and Rheumatism
Seminars in Arthritis and Rheumatism, 2020, 50, pp.1437-1440. ⟨10.1016/j.semarthrit.2020.02.009⟩
Seminars in Arthritis and Rheumatism, WB Saunders, 2020, 50, pp.1437-1440. ⟨10.1016/j.semarthrit.2020.02.009⟩
Web of Science
Seminars in Arthritis and Rheumatism, 2020, 50, pp.1437-1440. ⟨10.1016/j.semarthrit.2020.02.009⟩
Seminars in Arthritis and Rheumatism, WB Saunders, 2020, 50, pp.1437-1440. ⟨10.1016/j.semarthrit.2020.02.009⟩
Web of Science
International audience; Background: Our objective was to define the pattern and severity of muscle damage in immune-mediated necrotizing myopathy (IMNM) and its relationship with clinical and serological features.Methods: IMNM patients with a whole-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7837c40c69a31c209d563cd196112fef
https://hal.science/hal-03494062
https://hal.science/hal-03494062
Autor:
Anne Chalumeau, Cécile Masson, Marina Cavazzana, Tristan Felix, Vasco Meneghini, Anne De Cian, Isabelle André-Schmutz, Anna Cereseto, Wassim El Nemer, Giacomo Frati, Carine Giovannangeli, Clara Wollenschlaeger, Leslie Weber, Mario Amendola, Giulia Hardouin, Antonio Casini, Fulvio Mavilio, Annarita Miccio, Jean-Paul Concordet
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (7), pp.eaay9392. ⟨10.1126/sciadv.aay9392⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (7), pp.eaay9392. ⟨10.1126/sciadv.aay9392⟩
Editing the fetal γ-globin promoters in hematopoietic stem cells from sickle cell disease patients induces therapeutic γ-globin levels.
Sickle cell disease (SCD) is caused by a single amino acid change in the adult hemoglobin (Hb) β chain tha
Sickle cell disease (SCD) is caused by a single amino acid change in the adult hemoglobin (Hb) β chain tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f821ecb9947713ce7c6b250a43b2e0d1
https://hal-mnhn.archives-ouvertes.fr/mnhn-03100446
https://hal-mnhn.archives-ouvertes.fr/mnhn-03100446
Autor:
Jean-Paul Concordet, Mégane Brusson, Giulia Maule, Giulia Hardouin, Anna Cereseto, Marion Rosello, Giacomo Frati, Letizia Fontana, Annarita Miccio, Pierre Martinucci, Filippo Del Bene, Panagiotis Antoniou, Tristan Felix, Wassim El Nemer, Jeanne Martin
Publikováno v:
Blood. 138:562-562
β-hemoglobinopathies are caused by mutations affecting the adult hemoglobin production. In sickle cell disease (SCD), the β6 Glu→Val substitution leads to sickle hemoglobin (HbS) polymerization and red blood cell (RBC) sickling. In β-thalassemia
Autor:
Marina Cavazzana, Tristan Felix, Giandomenico Turchiano, Anne Chalumeau, Bochra Mlaya, Marion Rosello, Anna Cereseto, Giulia Hardouin, Jean-Paul Concordet, Filippo Del Bene, Mario Amendola, Antonio Casini, Annarita Miccio, Adrian J. Thrasher, Panagiotis Antoniou, Leslie Weber, Giacomo Frati, Carine Giovannangeli, Wassim El Nemer
Publikováno v:
Blood. 136:33-33
β-hemoglobinopathies are genetic anemias caused by a reduced or abnormal synthesis of the adult β-globin chain. In β-thalassemia, the reduced (β+) or absent (β0) production of adult β-chains causes α-globin precipitation and death of red blood